Discovery of isopentenyl flavonoids with inhibitory activity against hepatocellular carcinoma cells based on DeepSAT.

Isopentenyl flavonoids were isolated from Daphne giraldii Nitsche and their pharmacological activity was further studied to enrich its chemical composition. Seventeen isopentenyl flavonoids (1a/1b-3a/3b and 4-14), including thirteen undescribed compounds (1a/1b-3a/3b and 4-10), were obtained from D. giraldii under the guidance of HSQC-based DeepSAT.