Publications by authors named "Wen-Lei Deng"
The domain III (EDIII) of the envelope protein of Japanese encephalitis virus (JEV) is proposed to play an essential role in JEV replication and infection; it is involved in binding to host receptors and contains specific epitopes that elicit neutralizing antibodies. However, most previous studies have not provided detailed molecular information about the functional epitopes on JEV EDIII protein. In this study, we described a monoclonal antibody (mAb 2B4) we produced and characterized by IFA, PRNT, ELISA and Western blot analyses.
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- The bursa of Fabricius is crucial for B lymphocyte development and has potential antitumor activity through its derived peptides, specifically the newly identified BPP-II (MTLTG).
- BPP-II has been shown to influence a wide array of gene expressions related to immune responses, enhancing specific antibody and cytokine production in the presence of avian influenza.
- The peptide also promotes p53 expression and inhibits tumor cell growth, suggesting its role as an important factor in connecting the immune system and cancer therapy, paving the way for new immunotherapeutic strategies.