Publications by authors named "Wen-Kang Liu"
Background: Apoptosis-stimulating protein of p53 (ASPP) family members can stimulate the apoptotic function of p53 but have no impact on its cell cycle arrest function.
Material And Methods: The expression pattern of the ASPP family consisting of ASPP1, ASPP2, and iASPP was examined by immunohistochemistry in 45 formalin-fixed and paraffin-embedded endometrial endometrioid adenocarcinoma (EEA) specimens and 26 normal endometrial tissue (NET) samples.
Results: The expression rates of ASPP1 and ASPP2 in EEA were significantly lower than those in NET (p < 0.
Background: Endometrial cancer is the 4th most common gynecological cancer. The expression of prostate stem cell antigen (PSCA), piwi-like 1 (PIWIL1), and T-box 2 (TBX2) in endometrial cancer remains to be elucidated.
Material And Methods: The expression of PSCA, PIWIL1, and TBX2 was examined using the streptavidin-peroxidase method in 64 endometrial endometrioid adenocarcinoma (EAC) and paired normal endometrium (NE) samples from the Shaanxi Province in China.
The purpose of our study was to investigate the expression of prostate stem cell antigen (PSCA), piwi-like 1 (PIWIL1) and T-box 2 (TBX2) and its correlation with HPV16 infection in cervical squamous cell carcinoma (CSCC). HPV16 was detected by amplifying the HPV16 E7 gene by the polymerase chain reaction (PCR) method, and the expression of PSCA, PIWIL1, TBX2 and HPV16 E7 in 59 CSCCs and matched adjacent normal cervix (MANC) was examined by the streptavidin-peroxidase (SP) method. Fifty-two CSCCs and MANC specimens that were positive for the E7 gene and the E7 protein were identified as infected with HPV16 and included in present study.
View Article and Find Full Text PDFBackground: Esophageal cancer is the fourth most prevalent malignancy in China. The relationship between COX-2, CD44v6, and nm23H1 in esophageal squamous cell carcinoma (ESCC) remains unclear.
Material And Methods: Expression of COX-2, CD44v6, and nm23H1 was examined, using the streptavidin-peroxidase method, in 82 ESCC and 30 normal esophageal mucosa (NEM) samples from the Shaanxi Province in China.
Article Synopsis
- - The study aimed to explore the link between HPV16 infection and the proteins COX-2 and P53 in esophageal squamous cell carcinoma (ESCC), which was not previously understood.
- - The research showed that HPV16 and COX-2 were significantly more prevalent in ESCC samples compared to normal esophageal tissue, with correlations between COX-2 expression levels and tumor characteristics like stage and metastasis.
- - HPV16 infection negatively correlated with COX-2 overexpression but showed no significant relationship with P53 levels; however, higher COX-2 levels were positively linked to P53 expression in ESCC.
Detection of human papillomavirus type 16 DNA in formalin-fixed, paraffin-embedded tissue specimens of gastric carcinoma.
Eur J Gastroenterol Hepatol
December 2007
Article Synopsis
- The study investigates the role of Human papillomavirus type 16 (HPV16) in gastric carcinoma (GC), noting its stronger association with GC compared to adjacent normal tissue.
- Using Liquid PCR and in-situ PCR methods, researchers found HPV16 DNA was present in 37.5% of GCs but only 5% in normal tissues.
- Results suggest that HPV16 could be linked to the development of gastric cancer regardless of Helicobacter pylori infection, indicating a unique pathogenic mechanism in GC.