Plasma Choline as a Diagnostic Biomarker in Slow Coronary Flow.

Aim: The slow coronary flow (SCF) phenomenon was characterized by delayed perfusion of epicardial arteries, and no obvious coronary artery lesion in coronary angiography. The prognosis of patients with slow coronary flow was poor. However, there is lack of rapid, simple, and accurate method for SCF diagnosis.

Plasma homocysteine levels are independently associated with alterations of large artery stiffness in men but not in women.

Objectives: To investigate the associations of the plasma homocysteine levels with the alterations in arterial stiffness in a community-based cohort. The gender differences in these associations were examined.

Methods: We evaluated the relationship between plasma homocysteine levels to three measures of vascular function [carotid-femoral pulse wave velocity (CF-PWV), carotid-ankle PWV (CA-PWV) and heart rate corrected augmentation index (AI)] in 1680 participants (mean age: 61.

Plasma Homocysteine is a Predictive Factor for Arterial Stiffness: A Community-Based 4.8-Year Prospective Study.

The authors investigated whether plasma total homocysteine (tHcy) is a predictive factor for arterial stiffness (carotid-femoral pulse wave velocity [cf-PWV] and carotid-radial PWV) in 1447 patients from a 4.8-year prospective study in Beijing, People's Republic of China. Baseline tHcy showed a significant relationship with follow-up cf-PWV (β=0.

[Central pulse pressure but not brachial blood pressure is the predominant factor affecting aortic arterial stiffness].

Objective: To investigate the differences in central hemodynamic indices between hypertensive and normotensive subjects and identify the blood pressure index that the most strongly correlate with arterial stiffness and vascular damage markers.

Methods: A cohort of 820 hypertensive patients and 820 normotensive individuals matched for age and gender were enrolled in this study. We measured carotid-femoral and carotid-radial pulse wave velocity (PWV), aortic augmentation index (AIx) and central blood pressures using pulse wave analysis and applanation tonometry.

Association between serum homocysteine and arterial stiffness in elderly: a community-based study.

Background: Arterial stiffness and homocysteine are both powerful predictors of cardiovascular disease, especially in older populations. Previous studies have investigated the association of homocysteine with arterial stiffness in human subjects, while the relationship between homocysteine and arterial stiffness in the elderly is still indefinite. The current study examined the association of homocysteine with arterial stiffness in Chinese community-based elderly persons.

[Association between peroxisome proliferator-activated receptor gene single nucleotide polymorphisms and arterial stiffness in adult Chinese population].

Objective: To analyze the association between single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptor(PPAR) and arterial stiffness in adult Chinese population (> 50 years).

Methods: Cardiovascular risk factors from participants of Beijing epidemiological investigation were analyzed. Carotid-femoral pulse wave velocity (cfPWV) was measured by Complior system.

[Relationship between serum N-terminal pro-brain natriuretic peptide and metabolic syndrome: a cross-sectional study].

Objective: To explore the relationship between serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and metabolic syndrome (MS).

Methods: A total of 1323 Beijing residents (559 male) were investigated. MS was defined by the modified 2004 Chinese Diabetes Society criteria and 439 cases were diagnosed as MS according to this criteria.

Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function.

Objective: Both decreased glomerular filtration rate (GFR) and arterial stiffness were considered as risk factors for atherosclerosis. Previous studies have suggested the association between central arterial stiffness and the degree of GFR loss. Whether decreased GFR contributes to peripheral artery stiffness remains controversial.

[Relationship between serum homocysteine and metabolic syndrome: a cross-sectional study].

Objective: To explore the relationship between serum homocysteine and metabolic syndrome (MS).

Methods: A cohort with 1680 people involved in a community-based population in Beijing was investigated. Metabolic syndrome was defined by NCEP-ATPIII criteria.

Associations of plasma homocysteine and high-sensitivity C-reactive protein levels with arterial stiffness in Chinese population: a community-based study.

Background: Arterial stiffness increases with age and is also associated with traditional cardiovascular risk factors. Little is known about the relations of homocysteine and high-sensitivity C-reactive protein (hs-CRP) to arterial stiffness in the Chinese community. The aim of the present study was to investigate the association of plasma homocysteine and hs-CRP levels with arterial stiffness in a community-based cohort.

[Radial augmentation index is associated with cardiovascular risk and arterial stiffness].

Objective: To investigate whether radial augmentation index (AI) associates with cardiovascular risk as well as arterial stiffness.

Methods: A total of 4985 subjects, 2417 men and 2568 women, aged 18 - 96 (50.9 ± 14.

[Pressure wave reflections and central blood pressure in treated hypertensive subjects].

Objective: To investigate the differences in pressure wave reflections and central blood pressure between brachial BP classification and the effect of antihypertensive drugs.

Method: In 1371 chronically treated hypertensive subjects aged 33 - 87 years [679 males and 692 females, mean age (47.2 ± 11.

Influence of low high-density lipoprotein cholesterol on arterial stiffening and left ventricular diastolic dysfunction in essential hypertension.

The authors investigated whether high-density lipoprotein (HDL) cholesterol plays a role in arterial stiffening and left diastolic dysfunction in essential hypertension. Carotid arterial stiffness parameter and left ventricular (LV) diastolic function index were evaluated in 217 patients with essential hypertension. The correlations of dyslipidemia, especially low HDL cholesterol, to LV diastolic function and arterial stiffness were investigated in these patients.

[Clinical usefulness of carotid arterial wave intensity in noninvasively assessing left ventricular performance in different hypertensive remodeling hearts].

Objective: To evaluate wave intensity (WI) on left ventricular (LV) performance in the different hypertensive remolding hearts.

Methods: 105 hypertensive and 98 control subjects were underwent noninvasive evaluation of carotid arterial wave intensity, LV structure and function.

Results: (1) There were increasing trends in the levels of blood pressure, LV end-diastolic diameter and LV mass index in the control, normal geometry group, concentric remodeling group, concentric and eccentric hypertrophy group.

[The relationship between obesity and microalbuminuria among general population in Beijing area].

Objective: To investigate the correlation between microalbuminuria (MAU) and obesity and its indexes, including BMI, waist circumference (WC), and waist-to-hip ratio (WHR), among partial community population in Beijing.

Methods: A total of 2080 subjects who took physical examination in Beijing, including 810 men and 1270 women with a mean age of (50.9 ± 13.

[Correlations between different obese indexes and arterial stiffness among populations at the community level].

Objective: The aim of this study was to investigate the relationship between obesity [measured by body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR)] and arterial stiffness on community populations in Beijing area.

Methods: In a cross-sectional study of 2664 subjects (1379 men and 1285 women) aged (53.19 ± 15.

[Evaluation on left ventricular function by non-invasive transient deceleration wave intensity (W2) of carotid artery].

Objective: To evaluate transient deceleration wave intensity (W2) of carotid artery on left ventricular diastolic function.

Methods: 40 patients with hypertension and 43 healthy volunteers were enrolled and W2 of carotid artery of the both sides were measured. The parameters of left ventricular diastolic function by traditional and tissue Doppler imaging and NT-proBNP (N-terminal probrain natriuretic peptide) were measured.

[Associations and related factors between pulse wave velocity and arterial system and augmentation index measured on different sites in a healthy population].

Objective: To explore the associations and related factors between pulse wave velocity (PWV) and arterial system and augmentation index (AI) measured on different sites in a healthy population.

Methods: All subjects were selected from a local community investigation study which included 5116 people living in Haidian District or Daxing District, Beijing, China. A total of 729 healthy subjects [age 17 - 85 years, mean (39.

[Prevalence of microalbuminuria and its related factors among different genders in general population of Beijing].

Objective: Microalbuminuria (MAU) is generally defined as an early effective index of cardiovascular disease and renal disease. Our study aims to investigate the prevalence of MAU and its related factors among people living in Beijing.

Methods: In a cross-sectional study, 2080 subjects (810 men and 1270 women) are recruited, with age distribution as 50.

[Association of risk factors for cardiovascular disease and the rate of glomerular filtration: a cross-sectional study in the population from certain areas of Beijing].

Objective: Data from several large prospective studies revealed that a low glomerular filtration rate was independently associated with cardiovascular disease (CVD) events and all-cause mortality in high-risk populations. Much on the association was explained by traditional CVD risk factors. However, findings from population-based studies were scarce and inconsistent.

[Possible determinants of the radial augmentation index in 4985 Chinese population].

Objective: The augmentation index (AI) derived from central arteries is generally defined as an index of augmentation of central blood pressure in systole derived from the return of pressure waves reflected from the periphery and is an index of arterial stiffness. There is controversy with respect to how to affect AI.

Methods: In a cross-sectional study of 4985 subjects (2417 men and 2568 women) aged 18 - 96 years (50.