Kai-Xin-San Inhibits Tau Pathology and Neuronal Apoptosis in Aged SAMP8 Mice.

Alzheimer's disease (AD) is an age-related neurological disorder. Currently, there is no effective cure for AD due to its complexity in pathogenesis. In light of the complex pathogenesis of AD, the traditional Chinese medicine (TCM) formula Kai-Xin-San (KXS), which was used for amnesia treatment, has been proved to improve cognitive function in AD animal models.

New phenolic glycosides from Bunge and their antioxidant activity.

ABATRACTNine compounds, five phenolic glycosides (, , ), three phenylpropanoids (), and a furanone glycoside (), were isolated from aqueous soluble extract of the dried roots of Bunge. The structures of new compounds () were elucidated by comprehensive spectroscopic data analysis as well as chemical evidence. Pulsatillanin A () demonstrated significant antioxidant effects through scavenging free radical in DPPH assay, and relieved the oxidative stress in LPS-induced RAW 264.