Synergistic effects of atorvastatin and rosiglitazone on endothelium protection in rats with dyslipidemia.

Background: Endothelial dysfunction is implicated in the initiation and progression of atherosclerosis. Whether atorvastatin combined with rosiglitazone has synergistic effects on endothelial function improvement in the setting of dyslipidemia is unknown.

Methods: Dyslipidemia rat model was produced with high-fat and high-cholesterol diet administration.