Deleterious Mutations in DNA Repair Gene Exist in -Negative Chinese Familial Breast and/or Ovarian Cancer Patients.

is reported as a novel susceptibility gene for breast cancer, however, its mutation remains unclear in Chinese population. We aimed to identify the germline mutations of in high-risk breast cancer patients in China. 255 -negative Chinese familial breast and/or ovarian cancer (FBOC) patients were recruited for germline mutations screen.

Expression of integrin-binding protein Nischarin in metastatic breast cancer.

The present study aimed to investigate the expression of Nischarin protein in primary breast cancer (PBC), and to evaluate its role in tumor metastasis. Paired specimens of breast cancer tissues and adjacent normal tissues were surgically obtained from 60 patients with PBC at the Zhejiang Cancer Hospital (Hangzhou, China). Nischarin protein concentrations were determined by an ELISA assay.