Publications by authors named "Wen-Jin He"
Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial.
Jun Liu Dan-Dan Li Wei Dong Yu-Qi Liu Yang Wu Jing-Yu He Jiang-Bin Chen Jing He Wen-Jin He Hui-Jun Chen He-Ping Liu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yun-Dai Chen
Signal Transduct Target Ther
September 2021
Article Synopsis
- A study involving 920 patients with stable angina tested the efficacy of Danhong injection (DHI), a polypharmacological drug, over 14 days, finding that DHI significantly improved patient-reported angina frequency compared to a placebo.
- There were no significant differences in major vascular events or serious side effects between the DHI and placebo groups, indicating DHI's safety in this population.
- RNA sequencing identified a new therapeutic module related to blood coagulation and cholesterol metabolism as a potential target for DHI's effects, highlighting a connection between this module and positive changes in angina symptoms.
Aims: Despite numerous reports documenting an important role of hypertension in the development of atrial fibrillation (AF), the detailed mechanism underlying the pathological process remains incompletely understood. Here, we aim to test the hypothesis that diastolic sarcoplasmic reticulum (SR) Ca2+ leak in atrial myocytes, induced by mechanical stretch due to elevated pressure in the left atrium (LA), plays an essential role in the AF development in pressure-overloaded hearts.
Methods And Results: Isolated mouse atrial myocytes subjected to acute axial stretch displayed an immediate elevation of SR Ca2+ leak.