Publications by authors named "Wen-Jiao Xue"
Article Synopsis
- Cell senescence is a key mechanism of aging, and while its role in tissues like fat, pancreas, and liver in relation to type 2 diabetes is established, its direct effects on neurons are still unclear.
- In this study, researchers created a high glucose and palmitic acid (HGP) environment to simulate diabetes in neuronal cells and found that this condition triggered significant senescence-like traits in the neurons, linked to changes in specific proteins and cellular processes.
- The findings suggest that diabetes can directly lead to neuronal senescence by increasing NRSF/REST levels, which then disrupts the mTOR-autophagy pathway, indicating a potential target for future therapies.
Diabetes is one of the well-established risk factors of stroke and is associated with a poor outcome in patients with stroke. Previous studies have shown that the expression of neuron restrictive silencer factor (NRSF) is elevated in diabetes as well as ischemic stroke. However, the role of NRSF in regulating an outcome of diabetic ischemic stroke has not been completely understood.
View Article and Find Full Text PDFProbiotic Potential of Strains Isolated From Fermented Vegetables in Shaanxi, China.
Front Microbiol
February 2022
The objective of this study was to assess probiotic potential of strains derived from artisanal fermented vegetables in Shaanxi, China. In total, 74 acid-producing Gram-positive strains with rod-shaped under the microscope were isolated from 16 samples of spontaneously fermented vegetables. Out of 74 strains, 26 showed high survival rate under low pH and high bile salts conditions and were subjected to molecular identification by 16S rRNA gene sequencing analysis.
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- The study investigates the therapeutic effects of a novel compound, palmitic acid (5-PAHSA), on neurological dysfunction related to Type 2 diabetes by focusing on autophagy.
- In both in vitro (PC12 cells) and in vivo (DB/DB mice) experiments, 5-PAHSA was administered and showed promising results in decreasing oxidative stress and inflammation, although it did not significantly improve glucose metabolism.
- The findings suggest that while 5-PAHSA enhances autophagy and lowers specific inflammatory markers, it does not affect apoptosis or cognitive functions in diabetic mice.
Pullulan productions by CGMCC No.11602 were conducted using the initial culture (IC) medium and the optimized culture (OC) medium, respectively, in which pullulan with significantly different molecular weights was obtained. Under the IC medium condition, the pullulan molecular weight ( ) reached 288,403 Da with a yield of 64.
View Article and Find Full Text PDFPullulan is a natural exopolysaccharide with many useful characteristics. However, pullulan is more costly than other exopolysaccharides, which limits its effective application. The purpose of this study was to adopt a novel mixed-sugar strategy for maximizing pullulan production, mainly using potato starch hydrolysate as a low-cost substrate for liquid-state fermentation by Aureobasidium pullulans.
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- Researchers studied how to produce recombinant human-like collagen (RHLC) using genetically modified E. coli in a 30 L bioreactor, focusing on factors like temperature, pH, and nutrient ratios.
- They identified the best conditions for collagen production by combining genetic algorithms with artificial neural networks, leading to a specific temperature and pH setting.
- The optimal setup resulted in an experimental RHLC concentration of 12.1 g/L, close to the theoretical maximum of 12.5 g/L.