Publications by authors named "Wen-Jiang Yin"
Progranulin (PGRN) is a multi-functional growth factor known to be involved in regulating of development, cell cycle progression, cell motility, tumorigenesis and angiogenesis. Research has revealed that PGRN is a crucial mediator of skin wound healing. Nonetheless, the role of PGRN in the fibrosis process of cutaneous wound healing has not been identified.
View Article and Find Full Text PDFObjective: To observe the expression pattern of caspase-3 and HCLS1-associated protein X-1 (HAX-1) at different time after cerebral contusion in rat, and explore the new method for estimating the injury interval.
Methods: The cerebral contusion model was established using adult SD male rats. Then the rats were randomly allocated into 8 groups: 2 h, 6 h, 12 h, 1 d, 3 d, and 7 d after cerebral contusion, sham-operation and normal control.
Article Synopsis
- The study aimed to examine how caspase-3 and iNOS levels change over time after brain injuries in humans to help estimate the timing of these injuries.
- Thirty individuals who died from severe brain injuries were analyzed against a control group of five non-brain injury cases using immunohistochemistry.
- Results showed that caspase-3 levels increased significantly within 2 hours post-injury, remained elevated for several days, while iNOS levels started rising after 4 hours and peaked at 1-2 days before declining, indicating both markers can aid in assessing injury timing.