Publications by authors named "Wen-Jia Han"
Background: Diabetes is one of the common chronic diseases in which susceptibility is determined by a combination of genetic and environmental factors, and more than 90% of diabetic patients are diabetes mellitus type 2 (T2DM). The existing studies on the association between CDKAL1 rs10946398 gene polymorphism and susceptibility to type 2 diabetes are inconsistent across populations.
Aim: We aim to explore the association between CDKAL1 rs10946398 gene polymorphism and susceptibility to type 2 diabetes in different populations.
Article Synopsis
- Type 2 diabetes mellitus (T2DM) is rising globally, and research shows the KCNQ1 gene may play a role in susceptibility to the disease.
- A comprehensive review of studies found no significant association between the KCNQ1rs2237892C⟶T gene polymorphism and T2DM risk, despite analyzing a large sample of over 13,000 individuals.
- The study did observe a potential link in non-Asian populations while no association was found in Asian groups, suggesting racial differences in the gene's impact on diabetes susceptibility.