Proteomic investigation of the sinulariolide-treated melanoma cells A375: effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade.

Sinulariolide is an active compound isolated from the cultured soft coral Sinularia flexibilis. In this study, we investigated the effects of sinulariolide on A375 melanoma cell growth and protein expression. Sinulariolide suppressed the proliferation and migration of melanoma cells in a concentration-dependent manner and was found to induce both early and late apoptosis by flow cytometric analysis.

Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells.

The extracts from soft corals have been increasingly investigated for biomedical and therapeutic purposes. The aim of this study is to examine and analyze the anti-tumor effects of the genus Sinularia extract sinularin on A2058 melanoma cells using MTT assay, cell migration assay, wound healing assay, flow cytometric analysis, and proteomic analysis. Sinularin dose-dependently (1-5 μg/mL) inhibited melanoma cell proliferation while the treatment at identical concentrations suppressed cell migration.

An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.

Active compounds from natural products have been widely studied. The anti-tumor effects of 13-acetoxysarcocrassolide isolated from Formosan soft coral Sarcophyton crassocaule on bladder cancer cells were examined in this study. An MTT assay showed that 13-acetoxysarcocrassolide was cytotoxic to bladder female transitional cancer (BFTC) cells.

Characteristics of metals in nano/ultrafine/fine/coarse particles collected beside a heavily trafficked road.

Fine particles emitted from vehicles have adverse health effects because of their sizes and chemical compositions. Therefore, this study attempted to characterize the metals in nano (0.010 < Dp < 0.

Emission of heavy metals from animal carcass incinerators in Taiwan.

The metal emissions from three incinerators burning different feedstock in Taiwan were characterized in this study. It was found that the Incinerators A and B, treating pig carcasses and animal (including pigs) carcasses, respectively, had much higher metal concentrations in stack flue gases than Incinerator C that combusted medical wastes. However, Incinerator A obtained relative lower metal contents in fly ash and bottom ash than the other two incinerators, mainly because the former used a much lower feedstock rate (although burning at a lower temperature) than the latter.