Publications by authors named "Wen-Hui Xu"

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a critical method for diagnosing lung cancer. While EBUS-TBNA is commonly performed under conscious sedation, the potential benefits of conducting the procedure under general anesthesia and incorporating rapid on-site evaluation (ROSE) to enhance diagnostic yield remain uncertain. This study aims to investigate the impact of anesthesia methods and ROSE on the diagnostic efficacy of EBUS-TBNA for lung cancer.

View Article and Find Full Text PDF

Two new tropolone-bearing sesquiterpenoids (1-2), two new dolabrane-type diterpenoids (3-4) along with eight known compounds as ionone-type sesquiterpenoid (5), oleanane triterpenoid (6), vanillin and its derivative (7-8), neolignan (9), two lignans (10-11), flavanonol glycoside (12) were isolated from whole plants of Croton lauioides Radcl.-Sm. & Govaerts.

View Article and Find Full Text PDF
Article Synopsis
  • * Their structures were determined using various analytical methods like UV, IR, NMR, HRESIMS, and CD spectroscopy.
  • * The compounds showed selective inhibitory activity against DGAT1 with IC values between 60.4 and 84.6 μM, and potential binding sites for one compound were predicted through molecular docking.
View Article and Find Full Text PDF
Article Synopsis
  • The research investigates how a maternal high-fat diet and gestational diabetes affect the metabolism of lipids and the profile of polyunsaturated fatty acids (PUFA) in their offspring.
  • Offspring are classified into different groups based on their mother's diet and GDM status, and their PUFA composition and protein signaling are analyzed using techniques like gas chromatography and Western blotting.
  • Findings suggest that exposure to high-fat diets and gestational diabetes during early development can alter PUFA profiles and protein expression related to signaling pathways in male offspring as they grow into adulthood.
View Article and Find Full Text PDF

Rupr. is a traditional herb generally distributed in most areas of China, north Korea and Japan. The dried roots of Rupr.

View Article and Find Full Text PDF

Objectives: This study aimed to investigate the integrative effects and mechanisms of transcutaneous electrical acustimulation (TEA) on postprocedural recovery from endoscopic retrograde cholangio-pancreatography (ERCP).

Materials And Methods: A total of 86 patients for elective ERCP were randomly ordered to receive TEA (n = 43) at acupoints PC6 and ST36 or Sham-TEA (n = 43) at sham points from 24 hours before ERCP (pre-ERCP) to 24 hours after ERCP (PE24). Scores of gastrointestinal (GI) motility-related symptoms and abdominal pain, gastric slow waves, and autonomic functions were recorded through the spectral analysis of heart rate variability; meanwhile, circulatory levels of inflammation cytokines of tumor necrosis factor-α (TNF-α) and interleukin (IL)-10 and GI hormones of motilin, ghrelin, cholecystokinin (CCK), and vasoactive intestinal peptide (VIP) were assessed by enzyme-linked immunosorbent assay.

View Article and Find Full Text PDF

Objective: Fatty acids play a critical role in the proper functioning of the brain. This study investigated the effects of a high-fat (HF) diet on brain fatty acid profiles of offspring exposed to maternal gestational diabetes mellitus (GDM).

Methods: Insulin receptor antagonist (S961) and HF diet were used to establish the GDM animal model.

View Article and Find Full Text PDF

Background: Polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid (DHA), are critical for proper fetal brain growth and development. Gestational diabetes mellitus (GDM) could affect maternal-fetal fatty acid metabolism.

Objective: This study aimed to explore the effect of GDM and high-fat (HF) diet on the DHA transport signaling pathway in the placenta-brain axis and fatty acid concentrations in the fetal brain.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the impact of dietary patterns and maternal genetics on the concentration of polyunsaturated fatty acids (PUFAs) in breast milk from Chinese Han lactating mothers.
  • A survey was conducted with 370 participants, collecting data on dietary intake and breast milk samples to analyze PUFA levels and genetic variations.
  • Findings indicate that both maternal genetic factors and dietary intake significantly influence the PUFA levels in breast milk, highlighting the importance of essential fatty acids for breastfeeding mothers.
View Article and Find Full Text PDF

Ethnopharmacological Relevance: Rhododendron dauricum L. is a traditional herb mainly distributed in the northeast China, Mongolia, Korea Peninsula, and Russia Far East. The dried leaves of Rhododendron dauricum L.

View Article and Find Full Text PDF

The scaling problem in the water supply pipeline will increase the resistance coefficient of the pipeline and the pressure of the water supply pipeline, which will not only affect the operation safety of the water supply pipeline, but also cause energy waste. The scale in the pipeline will also enrich heavy metal ions and pathogenic microorganisms, affecting the safety of water supply water quality and causing secondary pollution of water quality. At present, a lot of research has been done on the composition structure and crystallization process of the scale.

View Article and Find Full Text PDF

Background: Fatty acids, especially polyunsaturated fatty acid (PUFA), are found abundantly in the brain and are fundamental for a fetus's growth. The fatty acid profiles of mothers and fetuses may be affected by maternal prepregnancy body mass index (pre-BMI), thus affecting fetal growth and development.

Methods: A total of 103 mother-fetus pairs were divided into overweight/obese (OW, = 26), normal weight (NW, = 60), and underweight (UW, = 17) groups according to pre-BMI.

View Article and Find Full Text PDF

Melon () is an important vegetable crop that has been subjected to domestication and improvement. Several varieties of melons with diverse phenotypes have been produced. In this study, we constructed a melon pan-genome based on 297 accessions comprising 168 Mb novel sequences and 4,325 novel genes.

View Article and Find Full Text PDF

Four new 19-nor-clerodane diterpenoids (1-4), one new 15,16-dinor-ent-pimarane diterpenoid (5) together with four known diterpenoids (6-9) were isolated from whole plants of Croton yunnanensis. The structures of these compounds were determined by extensive spectroscopic methods including 1D, 2D NMR, HR-ESI-MS, and by comparing their NMR data with those of previously reported compounds. The experimental and calculated electronic circular dichroism data were used to define their absolute configurations.

View Article and Find Full Text PDF

Background/aims: Gastrointestinal (GI) dysmotility in acute pancreatitis (AP) aggravates inflammation and results in severe complications. This study aimed to explore effects and possible mechanisms of transcutaneous electrical acustimulation (TEA) on abdominal pain, GI dysmotility, and inflammation in AP patients.

Methods: Forty-two AP patients were blindly randomized to receive TEA (n = 21) at acupoints PC6 and ST36 or Sham-TEA (n = 21) at sham points for 2 days.

View Article and Find Full Text PDF

Ethnopharmacological Relevance: The genus Picrasma belongs to the Simaroubaceae family and contains six species which are mainly distributed in tropical and subtropical regions of Asia and America. The barks, roots, stems, branches, or leaves of several Picrasma species have been applied as folk medicines to treat fever, sore throat, dysentery, eczema, nausea, loss of appetite, diabetes mellitus, cancer, and hypertension.

Aim Of The Study: A systematic summary on the botanic characterization, ethnopharmacological uses, phytochemistry, bioactivities and toxicity of species belonging to Picrasma was presented to facilitate the exploitation of the therapeutic potential of these plants.

View Article and Find Full Text PDF

Chiral-selective Tamm plasmon polariton (TPP) has been investigated at the interface between a cholesteric liquid crystal and a metasurface. Different from conventional TPP that occurs with distributed Bragg reflectors and metals, the chiral-achiral TPP is successfully demonstrated. The design of the metasurface as a reflective half-wave plate provides phase and polarization matching.

View Article and Find Full Text PDF

Streptomyces Sp FJS31-2 is a strain isolated from special habitat soils in the early stage of our laboratory for producing a new type of halogenated type II polyketide antibiotic with good anti-MRSA activity. In this experiment, a variety of chromatographic and spectroscopic methods was used to isolate and identify a milbemycin compound VM48130 from the ethyl acetate extract of the fermentation products. To investigate its bioactivity, Cell Counting Kit-8 (CCK-8) assay was used to test the cytotoxic activity of the compound against a variety of cancer cells (human liver cancer cell line MHCC97H and SK-Hep1, human nasopharyngeal carcinoma cell line CNE1, mouse melanoma cell line B16, human colon cancer cell line LOVO, human lung adenocarcinoma cell line A549) and normal cells (human bronchial epithelial cell line 16HBE, human normal liver cell line L02, human nasopharyngeal epithelial cell line NP69).

View Article and Find Full Text PDF

The present study aims to analyze the effects of breast-conserving surgery and modified radical mastectomy on operation indexes, Symptom checklist-90 scores and prognosis in patients with early breast cancer.The clinical data of 128 patients with breast cancer who were treated in our hospital from May 2015 to May 2016 were included into the analysis. These patients were divided into 2 groups, according to the different modes of operation (n = 64): control group, patients underwent modified radical mastectomy; observation group, patients underwent early breast conserving surgery.

View Article and Find Full Text PDF

Two new polyoxygenated cyclohexenes (1-2), one new benzoate derivative (3), and one new dineolignan (4) together with one known neolignan (5) were isolated from whole plants of Piper pleiocarpum. The structures of these compounds were determined by extensive spectroscopic methods including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. The C NMR spectra of the known compound 5 were completely assigned for the first time.

View Article and Find Full Text PDF

The cell wall-targeting echinocandin antifungals, although potent and well tolerated, are inadequate in treating fungal infections due to their narrow spectrum of activity and their propensity to induce pathogen resistance. A promising strategy to overcome these drawbacks is to combine echinocandins with a molecule that improves their activity and also disrupts drug adaptation pathways. In this study, we show that puupehenone (PUUP), a marine-sponge-derived sesquiterpene quinone, potentiates the echinocandin drug caspofungin (CAS) in CAS-resistant fungal pathogens.

View Article and Find Full Text PDF

The genus Amoora belongs to the Meliaceae family comprising approximately 25-30 species. Many Amoora species have been used as folk medicines for the treatment of many diseases. This review focuses on diverse chemical constituents from Amoora species as well as significant pharmacological activities.

View Article and Find Full Text PDF

The investigation of chemical constituents from the whole plants Chang ex Tseng resulted in the isolation of one new dineolignan, pleiocarpumlignan A (), along with one known benzoate derivative, -2,3-diacetoxy-1-[(benzoy1oxy)methyl]-cyclohexa-4,6-diene (), and two known neolignans (-) as (±)--dehydrodiisoeugenol (), (7,8,3')-△-3',6'-dihydro-3'-methoxy-3,4-methylenedioxy-6'-oxo-8,3',7,,4'-lignan (). Their structures were elucidated through extensive spectroscopic analyses including 1D, 2D NMR, HR-ESI-MS, and by comparison with the literature. All compounds (-) were firstly isolated from Chang ex Tseng.

View Article and Find Full Text PDF

Ferroptosis is a new form of regulated cell death which is different from apoptosis, necrosis and autophagy, and results from iron-dependent lipidperoxide accumulation. Now, it is found that ferroptosis is involved in multiple physiological and pathological processes, such as cancer, arteriosclerosis, neurodegenerative diseases, diabetes, antiviral immune response, acute renal failure, hepatic and heart ischemia/reperfusion injury. On the one hand, it could be found the appropriate drugs to promote ferroptosis to clear cancer cells and virus infected cells, etc.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionmjcsmt58vg4kfrur64befjinkcuh52b7): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once