Publications by authors named "Wen-Hui Huang"

Very high-average optical enhancement cavities (OECs) are being used both in fundamental and applied research. The most demanding applications require stable megawatt level average power of infrared picosecond pulses with repetition rates of several tens of MHz. Toward reaching this goal, we report on the achievement of 710 kW of stable average power in a two-mirror hemispherical optical enhancement cavity.

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VEXAS syndrome, an uncommon yet severe autoimmune disorder stemming from a mutation in the UBA1 gene, is the focus of this paper. The overview encompasses its discovery, epidemiological traits, genetic underpinnings, and clinical presentations. Delving into whether distinct genotypes yield varied clinical phenotypes in VEXAS patients, and the consequent adjustment of treatment strategies based on genotypic and clinical profiles necessitates thorough exploration within the clinical realm.

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Primary Sjögren's Syndrome (pSS) is a complex autoimmune disorder characterized by exocrine gland dysfunction, leading to dry eyes and mouth. Despite growing interest in biologic therapies for pSS, FDA approval has proven challenging due to trial complications. This review addresses the absence of a molecular-target-based approach to biologic therapy development and highlights novel research on drug targets and clinical trials.

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From paddle-wheel starting material NaRu(CO)·6HO, a family of edge-sharing bi-octahedral (ESBO) diruthenium(IV,IV) compounds formulated as RuO(CO)(HO)L·HO [L = piperazine (1) or 2-methylpiperazine (2), = 4, and L = 2,2-dimethylpiperazine (3), = 12] and RuO(CO)(OH){M(HO)}·HO [M = Mg (4), = 4, and Ni (5), = 2] were prepared and structurally characterized. The Ru dimer is chelated and bridged by two CO and two μ-O in a manner, and the Ru-Ru distances fall in the range 2.3808(6)-2.

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Background: Langerhans cell histiocytosis affecting the thyroid commonly presents with nonspecific clinical and radiological manifestations. Thyroid Langerhans cell histiocytosis is typically characterized by non-enhancing hypodense lesions with an enlarged thyroid on computed tomography medical images. Thyroid involvement in LCH is uncommon and typically encountered in adults, as is salivary gland involvement.

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Article Synopsis
  • - The study focuses on an endangered plant species with declining seed germination due to the seed coat's permeability and mechanical constraints, highlighting the urgent need for lab-based dormancy breaking methods.
  • - Researchers analyzed the effects of HSO and gibberellic acid (GA) treatments on the seed coat's structure and properties, finding that these treatments created water pathways for moisture entry and softened the seed coat.
  • - Results showed that during cold stratification, seeds experienced structural damage and changes in chemical composition, with GA reducing seed hardness and allowing better water absorption, which is crucial for successful germination.
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  • Tilia henryana is a rare tree found only in China, and its seeds struggle to grow because they're really good at staying dormant.
  • Scientists figured out a special method to help the seeds wake up and grow, which involves treating them with certain chemicals and keeping them cold for a while.
  • During this process, the seeds use a lot of fat for energy, and the levels of different nutrients and hormones in the seeds change to help them germinate better.
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Neural tissue engineering (NTE) has made remarkable strides in recent years and holds great promise for treating several devastating neurological disorders. Selecting optimal scaffolding material is crucial for NET design strategies that enable neural and non-neural cell differentiation and axonal growth. Collagen is extensively employed in NTE applications due to the inherent resistance of the nervous system against regeneration, functionalized with neurotrophic factors, antagonists of neural growth inhibitors, and other neural growth-promoting agents.

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Background: To develop an artificial intelligence (AI) model with radiomics and deep learning (DL) features extracted from CT images to distinguish benign from malignant ovarian tumors.

Methods: We enrolled 149 patients with pathologically confirmed ovarian tumors. A total of 185 tumors were included and divided into training and testing sets in a 7:3 ratio.

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Background: Prostate artery embolization (PAE) is a promising minimally invasive therapy that improves lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH). Transurethral resection of the prostate (TURP) is the gold standard therapy for LUTS/BPH.

Aim: To evaluate the efficacy and safety of PAE TURP on LUTS related to BPH.

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Background: In patients with mucopolysaccharidosis (MPS), systematic assessment and management of cervical instability, cervicomedullary and thoracolumbar junction spinal stenosis and spinal cord compression averts or arrests irreversible neurological damage, improving outcomes. However, few studies have assessed thoracic spinal involvement in MPS IVa patients. We aimed to evaluate thoracic spinal abnormalities in MPS IVa patients and identify associated image manifestations by CT and MRI study.

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Background: The study was aimed to compare the efficacy and safety of different sedation protocols of dexmedetomidine-remifentanil and propofol-remifentanil for percutaneous closure of atrial septal defects (ASD) under transthoracic echocardiography (TTE) guidance.

Material And Methods: From March 2020 to January 2021, of 114 patients screened, 59 ASD patients scheduled for percutaneous closure under TTE guidance were randomly allocated into the dexmedetomidine-remifentanil (D-R) group (n = 29) and the propofol-remifentanil (P-R) group (n = 30). The incidence of hemodynamic and respiratory adverse events, arterial blood gas analysis, induction and recovery time, pain score, infusion rate of remifentanil, satisfaction of the surgeon and patient, additional sedatives were collected for analysis and comparison.

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Circular RNAs (circRNAs) are implicated in the regulation of tumor progression via the "competitive endogenous RNAs (ceRNAs)" mechanism. We intended to explore the molecular mechanism of circRNA WW domain containing adaptor with coiled-coil (circWAC) in breast cancer (BC) progression. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blot assay were applied to analyze RNA and protein expression.

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Rheumatoid arthritis (RA) and osteoarthritis (OA) are two most common rheumatic diseases in the world. Although there are standard methods for the diagnosis of both RA and OA, the differentials in some cases are poor. With deepening research, the role of autophagy in maintaining cell homeostasis and thus enabling cells adapt to external environments has become increasingly prominent.

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Background: Macrophages are involved in the pathogenesis of idiopathic pulmonary fibrosis, partially by activating lung fibroblasts. However, how macrophages communicate with lung fibroblasts is largely unexplored. Exosomes can mediate intercellular communication, whereas its role in lung fibrogenesis is unclear.

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Introduction: Prospective memory (PM) is a multiphasic cognitive function important for autonomy and functional independence but is easily disrupted by pathological aging processes. Through cognitive simulation of perceptual experiences, mental imagery could be an effective compensatory strategy to enhance PM performance. Nevertheless, relevant research in individuals with amnestic mild cognitive impairment (MCI) has been limited, and the underlying mechanism of the therapeutic effect has not been sufficiently elucidated.

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Introduction: This study aimed to investigate the feasibility of generating pseudo dual-energy CT (DECT) from one 120-kVp CT by using convolutional neural network (CNN) to derive additional information for quantitative image analysis through phantom study.

Methods: Dual-energy scans (80/140 kVp) and single-energy scans (120 kVp) were performed for five calibration phantoms and two evaluation phantoms on a dual-source DECT scanner. The calibration phantoms were used to generate training dataset for CNN optimization, while the evaluation phantoms were used to generate testing dataset.

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Background: Papillary thyroid cancer (PTC) is the most common type of thyroid cancer. However, due to the lack of reliable prognostic biomarkers for PTC, overtreatment has been on the rise. Therefore, our research aims to identify new and promising prognostic biomarkers and provide fresh perspectives for clinical decision making.

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The current study compared attention profiles and functional connectivity of frontal regions in patients with early-stage subcortical ischemic vascular disease (SIVD) and Alzheimer's disease (AD). Twenty patients with SIVD, 32 patients with AD, and 23 subjects with normal cognition (NC) received cognition and resting-state functional MRI (rs-fMRI) evaluations. The Cognitive Abilities Screening Instrument (CASI) was used to assess global cognition, and simple attention, processing speed, divided attention, and vigilance/sustained attention were evaluated using the Digit Span Forward, Trail Making Test, Symbol Digit Modality Test, and Conners Continuous Performance Test, respectively.

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Background: An increasing number of studies suggest the importance of prospective memory (ProM) due to its functional relevance and sensitivity to neuropathology. However, its relevant neural substrates have not been sufficiently explored.

Objectives: The present study aimed to investigate the relationship between structural connectivity and both objective and subjective ProM measures in a group of non-demented people with subjective memory complaints, and to examine the potential of ProM measures to detect the difference between subjective cognitive decline (SCD) and mild cognitive impairment (MCI) in the pre-dementia stage.

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Article Synopsis
  • Monoclonal gammopathy of renal significance (MGRS) can cause kidney issues and lead to conditions like Henoch-Schönlein purpura nephritis (HSPN), particularly in adults who don't respond to traditional treatments.
  • A case study details a patient with HSPN related to IgA-κMGRS, who faced challenges like skin purpura and nephrotic syndrome but ultimately improved after a specific treatment regimen.
  • The study emphasizes the importance of recognizing MGRS in adult patients with HSPN, as proper diagnosis and tailored treatments can significantly enhance patient outcomes.
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  • The study investigates the role of two ADAM10 gene polymorphisms (rs514049 and rs653765) in genetic susceptibility to Alzheimer's disease (AD) using a sample of 362 AD patients and 370 healthy controls from China.
  • No significant overall differences in gene variants were found between AD patients and controls, but an age-at-onset analysis indicated that the rs653765 CC genotype was linked to lower ADAM10 levels and faster cognitive decline in late-onset AD patients.
  • The meta-analysis revealed that the rs653765 and rs514049 polymorphisms were associated with AD risk, suggesting that the CC genotype may reduce ADAM10 expression and influence sRAGE levels, possibly affecting the progression of AD.
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  • Pyoderma gangrenosum (PG) is a rare skin condition that causes painful sores and is usually seen in people with other immune diseases.
  • A 20-year-old woman had swelling in her legs and ulcers on her skin, along with stomach problems and less urine than normal.
  • Doctors found she had PG and another kidney issue, but she got better after treatment with special medicines called prednisolone and cyclosporine A.
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To compare visual attention performances and diffusion tensor imaging (DTI) between subjects with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), and to discover neuronal substrates related to visual attention performances. Thirty-nine subjects with SCD and 15 with MCI, diagnosed following neuropsychological tests and conventional brain magnetic resonance imaging, were recruited. All subjects were further examined by the Conners Continuous Performance Test 3 (CPT3) and DTI including fractional anisotropy (FA) and mean diffusivity (MD), in which group comparisons and stepwise linear regression were made.

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