Zebrafish Model-Based Assessment of Indoxyl Sulfate-Induced Oxidative Stress and Its Impact on Renal and Cardiac Development.

Kidney disease patients may have concurrent chronic kidney disease-associated mineral bone disorder and hypertension. Cardiovascular disease (CVD) and neuropathy occur due to kidney failure-induced accumulation of uremic toxins in the body. Indoxyl sulfate (IS), a product of indole metabolism in the liver, is produced from tryptophan by the intestinal flora and is ultimately excreted through the kidneys.

[Chemoinformatics study on antibacterial activity of traditional Chinese medicine compounds].

Objective: The structure-activity relationship between traditional Chinese medicine (TCM) compounds and antibacterial activity was studied by chemoinformatics approach.

Method: Cytoscape and its plug-in ChemViz were applied to compute the 2D chemical structure similarity and topological parameter TPSA (topological molecular polar surface area), which measures cell permeability of chemicals, between TCM compounds and clinical antibacterials. The overall degree of structure similarity was then calculated and represented by E-value for the eight categories of TCM compounds and the known antibacterials.

[Study on the comparison of high risk behaviors related to AIDS among different status of income in men who have had sex with men].

Objective: To explore the risk sexual behaviors related to AIDS among different status of income among men who have had sex with men and to provide relevant interventions for AIDS control and prevention.

Methods: Study objectives were recruited through target sampling and anonymous questionnaires were adopted. Men's sexual behaviors were reported under the categories as high, mid or low-income.