Publications by authors named "Wen-Huei Huang"
Article Synopsis
- L5 is a highly negatively charged subfraction of LDL that can cause cell death in vascular endothelial cells by inhibiting FGF2 transcription, and its levels are elevated in STEMI patients.
- Plasma L5 was significantly higher in patients with ST-segment elevation myocardial infarction (STEMI) compared to control subjects and negatively affected endothelial cell survival and FGF2 expression.
- Low doses of aspirin protected endothelial cells from the harmful effects of L5, presenting a new understanding of how aspirin may help prevent myocardial infarction.
Homocysteine (Hcy) contributes to atherogenesis and angiostasis by altering the phenotype of arterial endothelial cells (ECs). The present study was aimed at elucidating potential mechanisms by which Hcy can slow EC proliferation and induce EC apoptosis, thereby disrupting endothelial integrity. Given the strong mitogenic and antiapoptotic properties of fibroblast growth factor (FGF)2, we examined whether Hcy can modulate its expression.
View Article and Find Full Text PDFHypercholesterolemic human LDL contains oxidized subfractions that have atherogenic properties. Paradoxically, atherosclerosis incidence is low in patients with primary biliary cirrhosis (PBC), a disease characterized by marked increases in plasma LDL, including the LDL subfraction lipoprotein-X (Lp-X). To investigate the mechanisms underlying this paradox, we first examined the propensity to oxidation of unfractionated LDL isolated from PBC patients.
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