Publications by authors named "Wen-Hsiu Wang"
Article Synopsis
- Cancer cells have higher levels of reactive oxygen species (ROS) and are more susceptible to therapies that generate ROS, like ascorbic acid (HAsc), but effectiveness is limited by the need for high doses.
- The study introduces nitrogen-doped graphene oxide dots (NGODs) as a biocompatible catalyst that enhances HAsc therapy at manageable concentrations by generating additional ROS and depleting intracellular glutathione (GSH), which contributes to cancer cell damage.
- NGODs can also function as photosensitizers in photodynamic therapy, producing ROS when illuminated, leading to a promising new treatment that combines NGODs and HAsc for more effective tumor destruction while maintaining a high survival rate of normal cells.
Pneumocystis Jirovecii Pneumonia in Systemic Lupus Erythematosus: A Nationwide Cohort Study in Taiwan.
Arthritis Care Res (Hoboken)
September 2022
Objective: To evaluate Pneumocystis jirovecii pneumonia (PJP) infection risk in patients with systemic lupus erythematosus (SLE) in Taiwan.
Methods: We identified 24,367 patients with SLE from the National Health Insurance research database between 1997 and 2012 and compared the PJP incidence rates (IRs) with those in 243,670 age- and sex-matched non-SLE controls. PJP risk in the patients was evaluated using a Cox multivariate proportional hazards model.
Objective: Patients with systemic lupus erythematosus (SLE) are susceptible to herpes simplex virus (HSV) infection, which occasionally leads to severe complications including meningoencephalitis and keratitis. However, few attempts to analyse the associated incidence and risk factors have been made.
Methods: We enrolled patients with SLE recorded between 1997 and 2012 and compared the incidence rate (IR) of severe HSV infection, including meningoencephalitis, septicaemia, ocular and visceral involvement, and other specific complications demanding hospitalisation, with that of a non-SLE cohort.