Identifying Diagnostic and Prognostic Differentially Expressed Genes of Gastric Cancer Based on Bioinformatics Analyses of RNA-seq Data.

The abnormal expression of genes in serum may be associated with early diagnosis of patients with malignant tumors. This study was designed to screen for significantly differentially expressed genes (DEGs) that may be associated with gastric cancer using bioinformatic methods. RNA-seq data from gastric cancers were downloaded from the TCGA and GEO databases, and 1903 secretory genes were downloaded from the HPA database.

The Application of Two-Stage Operation for High-Risk Patients with Oesophageal Cancer Following Gastrectomy.

Background: Oesophageal replacement by colonic interposition remains a major challenge due to its complexity and high incidence of complications; here we applied the two-stage operation strategy to oesophageal replacement by colonic interposition in high-risk oesophageal cancer patients following gastrectomy.

Methods: We performed a retrospective analysis on the data of patients with a history of distal gastrectomy who underwent one-stage and two-stage oesophageal replacement by colonic interposition from February 2012 to February 2020, and explored the relationship between the staging strategy and postoperative outcomes.

Results: The clinical data of 93 patients were collected and analysed.

Defect Passivation by a Multifunctional Phosphate Additive toward Improvements of Efficiency and Stability of Perovskite Solar Cells.

The quality of perovskite films plays a crucial role in the performance of the corresponding devices. However, the commonly employed perovskite polycrystalline films often contain a high density of defects created during film production and cell operation, including unsaturated coordinated Pb and Pb, which can act as nonradiative recombination centers, thus reducing open-circuit voltage. Effectively eliminating both kinds of defects is an important subject of research to improve the power conversion efficiency (PCE).

Hydroxycinnamic Acid Amide Dimers from Goji Berry and Their Potential Anti-AD Activity.

Three undescribed hydroxycinnamic acid amide dimers 1-3 were isolated and identified from an extract of Goji berry. Their molecular structures were elucidated based on NMR, MS, and IR spectra analysis. Compounds 1-3 were hydroxycinnamic acid amide dimers, which possess a cyclic butane moiety formed by head-to-head connection.

Developing a Peak Extraction and Retention (PEER) Algorithm for Improving the Temporal Resolution of Raman Spectroscopy.

In spectroscopic analysis, push-to-the-limit sensitivity is one of the important topics, particularly when facing the qualitative and quantitative analyses of the trace target. Normally, the effective recognition and extraction of weak signals are the first key steps, for which there has been considerable effort in developing various denoising algorithms for decades. Nevertheless, the lower the signal-to-noise ratio (SNR), the greater the deviation of the peak height and shape during the denoising process.

Frequency-Specific Changes of Resting Brain Activity in Parkinson's Disease: A Machine Learning Approach.

The application of resting state functional MRI (RS-fMRI) in Parkinson's disease (PD) was widely performed using standard statistical tests, however, the machine learning (ML) approach has not yet been investigated in PD using RS-fMRI. In current study, we utilized the mean regional amplitude values as the features in patients with PD (n = 72) and in healthy controls (HC, n = 89). The t-test and linear support vector machine were employed to select the features and make prediction, respectively.

An alkynyl-protected Au nanocluster featuring PhC[triple bond, length as m-dash]C-Au-P^P motifs.

An alkynyl-protected gold nanocluster [Au40(PhC[triple bond, length as m-dash]C)20(dppm)4](SbF6)4 (dppm = bis(diphenylphosphino)methane) (1) has been synthesized. Single-crystal X-ray diffraction reveals that the cluster has a face-centered cubic (FCC) Au34 kernel that is made up of two Au20 units via sharing a rectangular face. Two linear PhC[triple bond, length as m-dash]C-Au-C[triple bond, length as m-dash]CPh staple motifs are located around the central part of the Au34 core, and four L-shaped PhC[triple bond, length as m-dash]C-Au-P^P staple motifs are located at the four corners of the Au34 core.

Isolation and Total Structure Determination of an All-Alkynyl-Protected Gold Nanocluster Au.

Total structure determination of a ligand-protected gold nanocluster, Au , has been successfully carried out. The composition of title nanocluster is Au (C≡CAr) (1; Ar=2-FC H -). The cluster 1 exhibits a quasi-spherical Russian doll-like architecture, comprising a Au two-shelled Mackay icosahedron (Au @Au ), which is further enclosed by a Au anti-Mackay icosahedral shell.

Dye-Doped Fluorescent Silica Nanoparticles for Live Cell and In Vivo Bioimaging.

The need for novel design strategies for fluorescent nanomaterials to improve our understanding of biological activities at the molecular level is increasing rapidly. Dye-doped fluorescent silica nanoparticles (SiNPs) emerge with great potential for developing fluorescence imaging techniques as a novel and ideal platform for the monitoring of living cells and the whole body. Organic dye-containing fluorescent SiNPs exhibit many advantages: they have excellent biocompatibility, are non-toxic, highly hydrophilic, optically transparent, size-tunable and easily modified with various biomolecules.

[Lemierre syndrome caused by Arcanobacterium haemolyticum: a case report and review of the literature].

Objective: To emphasize the importance of the early diagnosis and treatment of Lemierre syndrome caused by Arcanobacterium haemolyticum.

Method: A case of Lemierre syndrome caused by Arcanobacterium haemolyticum and three similar reported cases were reviewed.

Results: A man complained of fever with a sore throat, and examination found an enlarged left tonsil with prominent exudate, normal blood routine test and chest radiograph.