Publications by authors named "Wen-Guang Tian"
J Int Med Res
August 2020
Article Synopsis
- MicroRNA-122 (miR-122) is explored as a potential diagnostic biomarker for liver diseases, particularly in patients with HCV-related hepatocellular carcinoma (HCC).
- A systematic review of six relevant studies, totaling 354 cases and 420 controls, showed promising diagnostic metrics, including a sensitivity of 83% and specificity of 87%.
- Findings suggest that miR-122 is more effective in identifying HCV-related HCC compared to distinguishing it from cirrhosis, and smaller sample sizes yielded better diagnostic results.
Article Synopsis
- The study analyzed blood test results from 70 COVID-19 patients in Chongqing, categorizing them into those with and without diarrhea.
- Significant laboratory indicators like ESR, CRP, and lymphocyte count showed over 50% positivity across the cohort, highlighting their diagnostic value.
- Notably, while there was no statistical difference in GGT levels between the two groups, all diarrhea patients exhibited decreased GGT, suggesting its potential role in assessing intestinal dysfunction post-infection.
Article Synopsis
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and is primarily diagnosed using real-time RT-PCR, which has some accuracy limitations.
- Researchers developed a new peptide-based luminescent immunoassay that detects IgG and IgM antibodies to improve detection.
- The immunoassay showed positive rates of 71.4% for IgG and 57.2% for IgM in confirmed patients, suggesting it could enhance COVID-19 diagnosis when used alongside RT-PCR.
Article Synopsis
- In December 2019, COVID-19 caused by the novel coronavirus emerged in Wuhan, China, with limited information on its clinical and immunological effects in children.
- A study analyzed twelve pediatric COVID-19 patients, revealing that common symptoms were cough (75%) and fever (58.3%), while children exhibited a longer incubation period (average of 8 days) compared to adults.
- The immune profiles indicated that children had higher levels of T cells and B cells, which may relate to their milder symptoms, and it is recommended that testing for SARS-CoV-2 be conducted for children with potential exposure, regardless of symptoms.
Article Synopsis
- The study analyzed the antibody responses of 285 COVID-19 patients, finding that all tested positive for IgG within 19 days of symptom onset.
- IgG and IgM antibodies either developed at the same time or one after the other, reaching stable levels within 6 days post-seroconversion.
- Serological tests could aid in diagnosing COVID-19, especially in cases with negative RT-PCR results and in detecting asymptomatic infections.
Asian Pac J Trop Med
March 2016
Article Synopsis
- The study aimed to investigate how an ASK1 inhibitor (GS-459679) can protect against liver damage caused by acetaminophen in mice, focusing on its molecular mechanisms.
- Mice were divided into four groups, and those treated with GS-459679 showed reduced liver enzyme levels and inflammatory markers compared to those that received only acetaminophen, indicating protective effects.
- Results demonstrated that GS-459679 decreased ASK1 activation and oxidative stress, leading to lower liver damage and inflammation, suggesting a potential therapeutic role in acetaminophen-induced liver injury.
