Comparison of effectiveness and cost of different HCV testing strategies in high-risk populations in China.

High-risk populations are the predominant populations affected by hepatitis C virus (HCV) infection, and there is an urgent need for efficient and cost-effective HCV testing strategies for high-risk populations to identify potential undiagnosed HCV-infected individuals. This study compared several commonly used testing strategies and conducted effectiveness and cost analysis to select the appropriate testing strategy for diagnosing HCV infection in high-risk populations. Among the 2093 samples from high-risk populations in this study, 1716 were HCV negative, 237 were current HCV infection, 137 were past HCV infection, and three were acute early HCV infection.

Development and evaluation of serological screening based on one dried plasma spot for HIV, syphilis, and HCV.

Background: In the effort to prevent and control HIV/AIDS, China has established a national sentinel surveillance system. However, some sentinel sites face limitations in environmental resources and accessibility, prompting the exploration of alternative sample strategies. Dried plasma spots (DPS) samples are viewed as promising alternatives to traditional plasma samples due to their advantages, including sample stability, easy storage, and convenient transport.

The signal-to-cutoff ratios to predict HCV infection among people who inject drugs.

People who inject drugs (PWIDs) are primarily the high-risk population for HCV infection. This study aims to determine the optimal cut-off values for predicting HCV infection status based on the Signal-to-Cutoff (S/CO) ratio. In this study, a total of 719 PWIDs' samples were collected, and performed for screening test by ELISA assay, and followed by RIBA assay and NAT assay to detect HCV antibody and HCV RNA levels, respectively.

Exploration of an Efficient Simultaneous Molecular Detection Method of HIV, HCV, and Syphilis from a Single Dried Blood Spot.

Objective: The aim of the present study was to evaluate the performance of the simultaneous detection of HIV-1 RNA, HIV-1 DNA, and HCV RNA using one dried blood spot (DBS) as an alternative sample to plasma.

Method: A total of 571 paired DBS/plasma samples were collected from men who have sex with men (MSM) and injection drug users (IDUs), and serological and molecular assays were performed. Using plasma results as the reference standard, the performance of DBS tests for HIV-1 RNA, HIV-1 DNA, and HCV RNA was evaluated.

Evaluation of seven rapid diagnostic tests for detection of hepatitis C virus antibodies in China.

Rapid diagnostic tests as an attractive alternative to enzyme immunoassay could identify hepatitis C virus (HCV) infected persons more expeditiously. The availability of high performing and quality-assured rapid diagnostic tests are essential to scale-up HCV screening. The study was undertaken to evaluate the performance of seven domestic HCV rapid diagnostic tests kits.

CT-guided percutaneous cryoablation combined with systemic chemotherapy for liver metastases from esophageal carcinoma: Initial experience.

Objective: To explore the feasibility, safety and effectiveness of percutaneous cryoablation combined with systemic chemotherapy in the treatment of liver metastases from esophageal carcinoma (ECLM).

Materials And Methods: We retrospectively collected data of 16 patients who received CT-guided percutaneous cryoablation concurrent systemic chemotherapy for liver metastases after primary esophageal carcinoma resection. Functional Assessment of Cancer Therapy-General (FACT-G) was used for the assessment of quality of life (QOL), and overall survival (OS), progression-free survival (PFS) and complications were also evaluated.

[Epidemiological survey on the hepatitis C virus and its genotyping analysis in Henan province in 2012].

Objective: To investigate the prevalence and distribution of hepatitis C virus (HCV) genotypes in Henan province in 2012.

Methods: A total of 32 203 permanent residents (1 to 74 years old) in Henan were recruited using multi-stage random samping method from March to June 2012. All participants were asked to complete a questionnaire to collect demographic information, past medical history and the exposure history of risk factors.

[A sero-epidemiological study on hepatitis C in China].

Objective: To better understand and measure the status of hepatitis C virus (HCV) infection, we conducted a sero-epidemiological study using the remaining blood samples and data of the nationwide survey of hepatitis B in Chinese residents which was carried out in 2006.

Methods: The anti-HCV reagent was screened out from the reagents by the HCV infection blood serum plate with anti-HCV positives or negatives. This plate recognized the Murex 3.

HIV, HCV, and HBV co-infections in a rural area of Shanxi province with a history of commercial blood donation.

Background: Unhygienic blood collection in the early 1990s led to blood-borne infections in Central China. This study aimed to estimate human immunodeficiency virus (HIV) co-infection with hepatitis C and B viruses (HCV and HBV) and their risk factors in a rural area of Shanxi Province with a history of commercial blood donation.

Methods: A cross-sectional study was conducted in 2004.

[A preliminary clinical study of targeted cryoablation of prostate in the treatment of T3N0M0 prostate cancer].

Objective: To evaluate the clinical efficacy, safety and application value of rectal ultrasound-guided targeted cryoablation of prostate (TCAP) in the treatment of T3N0M0 prostate cancer.

Methods: Transrectal ultrasound (TRUS)-guided TCAPs were performed. And prostate-specific antigen (PSA), TRUS-measured prostate volume, endorectal magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) at before, 12, 24, 36 months after TCAP were recorded and evaluated.

[Percutaneous verterbreplasty combined with radiotherapy treating malignant vertebrate metastasis].

Objective: To evaluate retrospectively the treatment effects and side effects of malignant vertebrate metastasis who had received radiotherapy or percutaneous verterbreplasty (PVP) or PVP combined with radiotherapy.

Methods: Two hundred and sixty-three patients who had been diagnosed as malignant tumor with vertebrate metastasis received PVP (87 patients) or radiotherapy (111 patients) or PVP combined with radiotherapy (65 patients). Radiotherapy was done one week after PVP procedure in PVP combined with radiotherapy group.

Human immunodeficiency virus-1 genotypic drug resistance among volunteer blood donors in Yunnan, China.

Background: Drug resistance profiles of human immunodeficiency virus-1 (HIV-1) in treatment-naïve infections have been reported in developed countries. However, little is known in developing countries, including China, especially in treatment-naïve volunteer blood donors.

Study Design And Methods: Fifty-two HIV-1-positive samples of blood donors were collected from 2005 to 2006 in Yunnan, China.

[Experimental study of hepatic bloodflow to the effect of cryoablation].

Objective: To investigate the bloodflow of hepetatic artery to the effect of cryoablation.

Methods: Twenty dogs were divided into four groups randomly according to hepatic artery blood flow: completely occlusion of the hepatic artery(A), partial occlusion of the hepatic artery(B), increasing the hepatic artery blood flow(C) ,and no occlusion(D). Two areas of necrosis near portal hepatis (a)and far from it (b)were created in each of the 20 dog livers.