Interspecies introgressive hybridization in spiny frogs (Family Dicroglossidae) revealed by analyses on multiple mitochondrial and nuclear genes.

Introgression may lead to discordant patterns of variation among loci and traits. For example, previous phylogeographic studies on the genus detected signs of genetic introgression from genetically and morphologically divergent or . In this study, we used mitochondrial and nuclear DNA sequence data to verify the widespread introgressive hybridization in the closely related species of the genus , evaluate the level of genetic diversity, and reveal the formation mechanism of introgressive hybridization.

[Expression of P53, P63, and C-erbB-2 in endometrioid adenocarcinoma and their clinicopathological significance].

Background & Objective: Tumor suppressor gene p53 and oncogene C-erbB-2 are confirmed to have close relation with endometrioid adenocarcinoma (EC), few documents have been reported about their correlation. Its structural homology to p53, p63 has been considered as a tumor suppressor gene acompany with p53 mutation, but its suppressive nature has not been confirmed yet; reports about p63 expression in EC are rare. This study was designed to investigate the roles of p53, p63, and C-erbB2 in tumorigenesis and development of EC, and their correlation with clinicopathological features of EC.