Publications by authors named "Wen-Cai Weng"
The noradrenergic fibers of the locus coeruleus, together with mossy fibers and climbing fibers, comprise the three types of cerebellar afferents that modulate the cerebellar neuronal circuit. We previously demonstrated that noradrenaline (NA) modulated synaptic transmission in the mouse cerebellar cortex via adrenergic receptors (ARs). In the present study, we investigated the effect of NA on facial stimulation-evoked cerebellar molecular layer interneuron (MLI)-Purkinje cell (PC) synaptic transmission in urethane-anesthetized mice using an in vivo cell-attached recording technique and a pharmacological method.
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- The study investigates the antitumor effects of Xihuang pill (XHP) on Treg cells in a 4T1 breast tumor mouse model, focusing on the PI3K/AKT/AP-1 signaling pathway.
- Flow cytometry and immunohistochemistry revealed that XHP significantly reduced Treg cell numbers and tumor weight, while TUNEL assays showed increased apoptosis of Treg cells with higher doses of XHP.
- Molecular analyses indicated that XHP inhibited PI3K and AKT and increased AP-1 mRNA and protein levels in Treg cells, suggesting that it helps combat tumor growth by improving the immune response in the tumor microenvironment.