Publications by authors named "Wen-Bo Yao"
Article Synopsis
- The research focused on the role of the human antigen R (HuR) RNA-binding protein in regulating calcium-driven thermogenesis in brown adipocytes, highlighting that its deletion leads to a dysfunction in thermogenesis and a decrease in crucial calcium transport genes.
- The study found that HuR stabilizes the mRNA of ryanodine receptor 2 (RyR2), which is vital for calcium signaling and heat generation; its depletion results in impaired thermogenic response, especially under cold stress.
A cascade spiroannulation of 2-mercaptoquinoline-3-carbaldehydes with α,α-dicyanoalkenes as well as a cascade spiroannulation of 2-mercaptoquinoline-3-carbaldehydes aldehydes with α-bromocarbonyl compounds was investigated based on a synergistic strategy, providing a series of diverse spiro-fused heterocyclic compounds containing more different functional groups. The features of this strategy directed towards molecular complexity and diversity include step economy, mild conditions, and high bond-forming efficiency, but important polycyclic heterocyclic products, which could be transformed into potential biologically interesting heterocyclic structures.
View Article and Find Full Text PDFIrisin has gained attention because of its potential applications in the treatment of metabolic diseases. Accumulating evidence indicates that irisin attenuates obesity via the browning of white adipose tissue; however, the underlying mechanisms are unclear. Here, we evaluated the effects of irisin on adipocyte browning and the underlying mechanisms.
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