Chondrocytes are unique resident cells in the articular cartilage, and the pathological changes of them can lead to the occurrence of osteoarthritis(OA). Ligusticum cycloprolactam(LIGc) are derivatives of Z-ligustilide(LIG), a pharmacodynamic marker of Angelica sinensis, which has various biological functions such as anti-inflammation and inhibition of cell apoptosis. However, its protective effect on chondrocytes in the case of OA and the underlying mechanism remain unclear.
View Article and Find Full Text PDFBackground: Obese type 2 diabetes mellitus (obese T2DM) is one of the prime diseases that endangers human health. Clinical studies have confirmed the ability of the Huanglian Huazhuo capsule to treat obese T2DM; however, its mechanism of action is still unclear. In this study, effects and mechanisms of the Huanglian Huazhuo capsule in obese T2DM were systematically investigated using network pharmacology and molecular docking techniques.
View Article and Find Full Text PDFA field experiment with five treatments, control (CK, no fertilizer), conventional fertilization (U), double-effect inhibitor synergistic urea (DU), coated urea (CU) and slow/controlled release urea mixture (CDU), was conducted to investigate the effects of conventional fertilization (240 kg N·hm) and one-off application of different slow/controlled release fertilizers (180 kg N·hm) on the yield and quality of fresh maize, soil inorganic nitrogen (N), and ammonia (NH) emissions. The results showed that the total amount of ammonia volatilization was the highest in treatment of conventional fertilization (U), with N topdressing being an important source of NH emission. Compared with U treatment, the NH volatilization in the DU, CU, and CDU treatments was reduced by 78%-81%.
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