Publications by authors named "Wen-Bin Wan"
Article Synopsis
- * An analysis of 1,396 hospitalized diabetic patients revealed a 7.09% prevalence of PAD, with those in the high ACR group exhibiting lower ankle-brachial index (ABI) levels compared to those with normal ACR.
- * The findings suggest that higher ACR levels increase the risk of PAD, indicating a significant relationship that persists even after adjusting for other potential risk factors.
Human Umbilical Cord Mesenchymal Stem Cells to Treat Neuromyelitis Optica Spectrum Disorder (hUC-MSC-NMOSD): A Study Protocol for a Prospective, Multicenter, Randomized, Placebo-Controlled Clinical Trial.
Xiao-Ying Yao Li Xie Yu Cai Ying Zhang Ye Deng Yi-Shu Wang Ze Wang Li-Ping Wang Wen-Bin Wan Kan Wang
Front Neurol
April 2022
Article Synopsis
- Neuromyelitis Optica spectrum disorder (NMOSD) is a serious autoimmune disease affecting the central nervous system, and the best initial treatment options are still uncertain.
- Researchers will conduct a clinical trial involving 430 NMOSD patients to assess the safety and efficacy of human umbilical cord mesenchymal stem cells (hUC-MSCs), looking for the optimal dosage.
- This trial is significant as it aims to provide the first systematic evaluation of hUC-MSCs' clinical safety and effectiveness for NMOSD, potentially identifying the best treatment dose for patients.
Alzheimer's disease (AD) is the most common form of senile dementia which is characterized by abnormal amyloid beta (Aβ) accumulation and deposition in brain parenchyma and cerebral capillaries, and leads to blood-brain barrier (BBB) disruption. Despite great progress in understanding the etiology of AD, the underlying pathogenic mechanism of BBB damage is still unclear, and no effective treatment has been devised. The standard Ginkgo biloba extract EGb761 has been widely used as a potential cognitive enhancer for the treatment of AD.
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