Publications by authors named "Wen-Bin Hou"
Article Synopsis
- Head and neck squamous cell carcinoma (HNSCC) has a high recurrence rate and low survival, leading to poor patient quality of life, but SM-1, derived from PAC-1, could be effective in enhancing treatment outcomes.
- This study analyzed the effects of SM-1 on HNSCC cell lines using various methods, discovering that it not only inhibited cell growth but also worked better than other treatments when combined with radiation.
- Results indicated that SM-1 causes G2/M phase cell cycle arrest and apoptosis by activating caspase-3, suggesting its potential as a radiosensitizer for HNSCC in future clinical trials.
Article Synopsis
- Radiation-induced intestinal injury (RIII) is a common problem for people getting radiation therapy for cancer which can make them feel worse and hurt treatment effectiveness.
- There are different ways to treat RIII including medicine, hyperbaric oxygen therapy, and surgery, but using medicine is often cheaper and effective.
- Traditional Chinese medicine (TCM) has components that can help protect the intestines from RIII with fewer side effects, showing promise in making people feel better by reducing stress and inflammation in the body.
Background: To explore the effectiveness and safety of Chinese herbal medicine (CHM) for drug-induced liver injury (DILI) in patients with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS).
Methods: A systematic search was made of eight databases (Pubmed, Cochrane Library, Web of Science, Embase, CNKI, Wanfang, VIP, Sinomed) and two trial registries (WHO ICTRP, ClinicalTrials.gov) from inception to September 2022.
Background: Acupuncture is commonly used for cancer-related conditions worldwide, and evidence is increasing year on year. There is a need to summarize the evidence of acupuncture for cancer-related conditions comprehensively and critically.
Objective: To evaluate and summarize the systematic reviews (SRs) that assess the effects and safety of acupuncture for cancer-related conditions, and to inform clinical practice and future studies.
Five-Flavor Enteric-Coated Capsules for Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Evid Based Complement Alternat Med
January 2022
Background: Ulcerative colitis (UC), a chronic inflammatory bowel disease, is characterized by abdominal pain, diarrhea, and mucopurulent bloody stool. In recent years, the incidence and prevalence of UC have been increasing consistently. Five-flavor enteric-coated capsule (FSEC), a licensed Chinese patent medicine, was specifically used to treat UC.
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- Berberis amurensis is a traditional Chinese medicine used to treat various ailments like hypertension and inflammation, containing key alkaloids such as berberine and magnoflorine.
- A study utilizing advanced analytical techniques identified 46 metabolites in normal rats, revealing metabolic pathways involved in the herb's metabolism, while only 29 metabolites were found in antibiotic-treated pseudo germ-free rats.
- The findings suggest that gut bacteria significantly impact the metabolism of Berberis amurensis, offering insights that could enhance its clinical effectiveness.
Background: Compound glycyrrhizin injection (CGI) is a preparation with glycyrrhizin as the main active ingredient extracted from licorice. As clinical trials suggest that CGI is effective in improving liver function for acute icteric hepatitis in children (AIHC), this systematic review aimed to evaluate and verify its therapeutic effects and safety.
Methods: Six electronic databases were searched from their inception to 15 May 2021.
An evidence mapping of systematic reviews and meta-analysis on traditional Chinese medicine for ulcerative colitis.
BMC Complement Med Ther
September 2021
Background: Traditional Chinese Medicine (TCM) has been a proposed treatment option for ulcerative colitis (UC), however it has been difficult to understand the breadth and depth of evidence as various Chinese medicine therapies may produce effects differently. The aim of this evidence mapping is to visually understand the available evidence in the use of TCM in the treatment of UC, and to identify gaps in evidence to inform priorities of future research.
Methods: A systematic electronic literature search of six databases were performed to identify systematic reviews (SRs) on different Chinese medicine therapies in the treatment in UC.
Objective: To evaluate the effectiveness and safety of Chinese patent medicine for mild-to-moderate active ulcerative colitis (UC) using network meta-analysis (NMA).
Methods: We systematically searched PubMed, Cochrane library, Embase, Sino-Med, China National Knowledge Infrastructure (CNKI), Wanfang, and Chinese Scientific Journal Database (VIP) databases to October, 2020. We included randomized controlled trials (RCTs) on Chinese patent medicine for mild-to-moderate active UC.
[This corrects the article DOI: 10.1016/j.chmed.
View Article and Find Full Text PDFSix-Transmembrane Epithelial Antigene of the Prostate 1 (STEAP1) is associated with the occurrence and development of cancer. This study aimed to clarify the role of STEAP1 in gastric cancer tumour growth and metastasis, as well as its molecular mechanism of action.Statistical methods were used for clinical data analysis.
View Article and Find Full Text PDFPurpose: To investigate lipase C hepatic type (LIPC) expression in Borrmann type 4 gastric cancer and its correlation with clinical outcome. The biological roles of LIPC in Borrmann type 4 gastric cancer progression were also investigated.
Methods: We determined LIPC expression in 324 primary gastric cancer tissues and 178 matched adjacent non-tumor tissues by immunohistochemistry.
We integrated changes in the trends in clinicopathologic characteristics and postoperative prognosis in patients with gastric cancer Northern China over a 30-year period. A retrospective analysis of patients undergoing gastric cancer resection and complete follow-up information from January 1981 to December 2010 in the first affiliated Hospital of China Medical University was carried out. We divided the patients into three consecutive periods.
View Article and Find Full Text PDFObjective: To investigate the therapeutic effect of total iridoid glycosides of (TIGP) on non-alcoholic steatohepatitis (NASH).
Methods: SD rats were fed with high-fat and high-sugar diet for 8 weeks to establish NASH. TIGP were given orally at doses of 20, 40 and 80 mg/kg/d for 4 weeks.
Objectives: To investigate the prognosis value of lymphatic vessel invasion (LVI) in pN0 gastric cancer patients with insufficient examined lymph nodes (ELNs).
Methods: Clinicopathologic and prognostic data of pN0 gastric cancer patients with insufficient ELNs who underwent radical surgery in our institution were retrospectively studied.
Results: Firstly, we confirmed that less than 16 but not less than 30 ELNs were insufficient ELNs in the present study.
Purpose: To investigate the survival of stage N3b patients with advanced gastric cancer (AGC) after radical surgery and to evaluate the TNM staging of subgroups of stage N3b patients.
Methods: We reviewed the data of 222 stage N3b patients with AGC who underwent D2/D3 radical surgery. Depending on the number of metastatic lymph nodes (MLNs), we divided N3b patients into several groups and compared the survival differences among them.
Aim: To isolate triterpene saponins of polygalacic acid type from the roots of Platycodon grandiflorum (Jacq.) A. DC and to identify their structures.
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