Anti-inflammatory Polyketides from the Marine-Derived Fungus .

Three new polyketides, eutyketides A and B ( and ) and cytosporin X (), along with four known compounds (-), were obtained from the marine-derived fungus . The planar structures of and were elucidated by extensive HRMS and 1D and 2D NMR analyses. Their relative configurations of C-13 and C-14 were determined with chemical conversions by introducing an acetonylidene group.

Promoting Effect of Horticultural Therapy on College Students' Positive Psychological Quality.

To explore the effect of horticultural therapy on cultivating College Students' positive psychological quality and to provide reference for college students' mental health education, 176 college students were randomly divided into experimental group ( = 88) and control group ( = 88). The experimental group was intervened by horticulture therapy, and the and were used to test the experimental group and the control group. There was no difference in the six dimensions of positive psychological quality between the experimental group and the control group in the pre-test.

Pemetrexed-based chemotherapy for non-small-cell lung cancer patients with exon 20 insertion mutation: a multicenter study.

Background: Chemotherapy is the major choice for advanced non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor exon 20 insertion (EGFR ex20ins). The efficacy of pemetrexed-based with other chemotherapy regimens and EGFR ex20ins subtypes in this population has not been well studied.

Methods: We screened patients with EGFR ex20ins by next-generation sequencing (NGS) from a large cohort.

Absolute Configurations and Chitinase Inhibitions of Quinazoline-Containing Diketopiperazines from the Marine-Derived Fungus .

Three new quinazoline-containing diketopiperazines, polonimides A-C (-), along with four analogues (-), were obtained from the marine-derived fungus . Among them, and , and were epimers, respectively, resulting the difficulty in the determination of their configurations. The configurations of - were determined by 1D nuclear overhauser effect (NOE), Marfey and electron circular dichroism (ECD) methods.

Development of c‑MET‑specific chimeric antigen receptor‑engineered natural killer cells with cytotoxic effects on human liver cancer HepG2 cells.

In recent years, cellular immunotherapy has served an important role in the combined treatment of hepatocellular carcinoma. The possibility of specific cell therapies for the treatment of solid tumours has been further explored following the success of chimeric antigen receptor (CAR)‑T cell therapy in the treatment of haematological tumours. The present study aimed to evaluate the specificity and efficiency of c‑MET‑targeted CAR‑NK cell immunotherapy on human liver cancer in vitro.

Stable Diindeno-Fused Corannulene Regioisomers with Open-Shell Singlet Ground States and Large Diradical Characters.

The synthesis of open-shell polycyclic hydrocarbons with large diradical characters is challenging because of their high reactivities. Herein, two diindeno-fused corannulene regioisomers DIC-1 and DIC-2, curved fragments of fullerene C , were synthesized that exhibit open-shell singlet ground states. The incorporation of the curved and non-alternant corannulene moiety within diradical systems leads to significant diradical characters as high as 0.

The Antitumor Effect of Xihuang Pill on Treg Cells Decreased in Tumor Microenvironment of 4T1 Breast Tumor-Bearing Mice by PI3K/AKT~AP-1 Signaling Pathway.

To study the antitumor effect of Xihuang pill (XHP) on the number of Treg cells in the tumor microenvironment of 4T1 breast tumor-bearing mice by PI3K/AKT/AP-1 pathway, a mouse model was established. Flow cytometry (FCM) and immunohistochemistry (IHC) were used to detect the number of Treg cells in the tumor microenvironment; terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) was used to detect the apoptosis of Treg cells in tumor microenvironment. Quantitative real-time PCR (RT-qPCR) was used to detect the mRNA expression of PI3K, AKT, and AP-1 in Treg cells in tumor microenvironment; immunofluorescence (IF) and Western Blot (WB) were used to detect the protein expression of PI3K, AKT, and AP-1 in Treg cells in tumor microenvironment.

A Robust Range Grating Lobe Suppression Method Based on Image Contrast for Stepped-Frequency SAR.

The magnitude error and phase error (MEPE) in the transfer function of a stepped-frequency synthetic aperture radar (SAR) system results in a periodic MEPE in the synthesized wideband waveform (SWW), which induces the grating lobes in the high-resolution range profile (HRRP). In this paper, a robust data-driven grating lobe suppression (GLS) method is proposed. Based on a contrast-based error estimation method and the grating lobes of the brightest scatterers in the SAR image, the periodic MEPE can be robustly estimated using the proposed method.

A new compound from an endophytic fungus Bambusicola massarinia.

One new chromone, rel-(1S,2S,3S)-2,8-dihydroxy-6-methoxy-1,3-dimethyl-3,4-dihydro-1H-xanthen-9(2H)-one (1), together with one known compound wentiquinone A (2), were isolated from solid culture of endophytic fungus strain Bambusicola massarinia. The structures of all compounds were determined mainly by analysis of their NMR spectroscopic data. The relative configuration of compound 1 was determined by the single-crystal X-ray diffraction analyses.

Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration.

Background: An accumulation of hyperphosphorylated tau in the brain is a hallmark of Alzheimer's disease (AD). Deficits in protein phosphatase 2A (PP2A) are associated with tau hyperphosphorylation in AD.

Objective: To investigate the effects of morroniside (MOR), isolated from Cornus officinalis, on tau hyperphosphorylation and its underlying mechanisms related to PP2A.

Actin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition.

Unlabelled: Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide because of metastasis. Epithelial-mesenchymal transition (EMT) is widely considered to be crucial to the invasion-metastasis cascade during cancer progression. Actin-like 6A (ACTL6A) is initially verified important for cell proliferation, differentiation, and migration.

Analysis of mutation of the c-Kit gene and in gastrointestinal stromal tumors.

The aim of the present study was to investigate mutation status of the and in patients with a gastrointestinal stromal tumor (GIST). In total, 93 patients with a GIST were included in the study, in which polymerase chain reaction amplification and gene sequencing were used to detect the sequences of exons 9, 11, 13 and 17 in and exons 12 and 18 in . mutations were detected in 64 cases (68.

Association between EML4-ALK fusion gene and thymidylate synthase mRNA expression in non-small cell lung cancer tissues.

This study aimed to investigate the association of the mRNA expression of the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene with that of thymidylate synthase (TYMS) in non-small cell lung cancer (NSCLC) tissues. Quantitative polymerase chain reaction was used to detect the expression of EML4-ALK fusion gene and TYMS mRNA in 257 cases of NSCLC. The positive rate of EML4-ALK fusion gene was 4.

Association between epidermal growth factor receptor mutations and the expression of excision repair cross-complementing protein 1 and ribonucleotide reductase subunit M1 mRNA in patients with non-small cell lung cancer.

The present study aimed to investigate the association between epidermal growth factor receptor () gene mutations and excision repair cross-complementing protein 1 () and ribonucleotide reductase subunit M1 () mRNA expression in non-small cell lung cancer (NSCLC) tissue. The quantitative polymerase chain reaction was used to detect mutations, and and mRNA expression in 257 cases of NSCLC. In the NSCLC samples the mutation rate was 49.

Evaluation and identification of microRNA-106 in the diagnosis of cancer: a meta-analysis.

Recently, extensive research has identified the non-invasive and cost-effective biomarker microRNA-106 (miR-106) in cancer detection. However, inconsistent results have prevented its usage in clinical. Therefore, we conducted this meta-analysis aimed to systematically determine diagnostic accuracy of miR-106 in distinguishing patients with cancer from cancer-free controls and further evaluate its value serving as a biomarker in clinical.

[Experimental study on anti-tumor effect of xihuang pill and its immune clearance function].

Objective: To discuss the anti-tumor effect of Xihuang pill on tumor-bearing rats and its effect on the immune clearance function of tumor-bearing organisms.

Method: Walker256 tumor cells were adopted to establish the tumor-bearing rat model. The rats were randomly divided into five groups: the normal control group, the model control group, the lentinan group and Xihuang pill low dose, middle dose and high dose groups, with 10 rats in each group, and continuously treated and given drugs for 14 d after modeling.

[Impact of sleep duration on cognitive functions among preschoolers].

Objective: To explore the effect of sleep duration including napping, night sleep and total sleep duration on cognitive functions among preschoolers.

Methods: The samples consisted of 94 preschoolers, aged from 2.58 to 6.

[Psychological resilience features of urban migrant children and rural left-behind children in Sichuan province of China].

Objective: To explore the characteristics of resilience of urban migrant children and rural left-behind children of Chinese farmer workers and to figure out the discrepancy between them.

Methods: The samples consisted of 1 391 primary students and middle school students from Chengdu, Guangyuan, Yibin, and Mianyang in Sichuan Province. The revised version of the Healthy Kids Resilience Assessment was used for the measurement of resilience.

[Study on the relationship among lifestyle, self-esteem and life satisfaction in Chinese adolescents].

Objective: To explore the relationship between lifestyle, self-esteem and life satisfaction among Chinese adolescents.

Methods: 10 899 adolescents in middle schools and colleges from 9 provinces in China were investigated by using Chinese Adolescent Lifestyle Scale (CALS), Rosenberg Self-Esteem Scale (SES).

Results: The distribution of adolescents in the four groups divided by lifestyle and life satisfaction scores were different regarding the area and grade of these students(chi(2)=248.

[Relationship between coping behavior and mental health of military medical laboratory scientists and technicians].

Objective: To study the relationship of coping behavior and mental health of military medical researchers and technicians.

Methods: A cross-sectional survey was conducted, using the self-rating anxiety scale (SAS), self-rating depression scale (SDS), and self-rating scale of coping behavior, among 325 military medical laboratory scientists and technicians with different professional titles.

Results: The anxiety and depression scores of the military medical researchers and technicians were 30 +/- 6 and 37 +/- 8 respectively, both significantly lower than those of the national norm (34 +/- 6 and 42 +/- 11 respectively, both P < 0.

[Observation on efficiency of shelian capsule as adjuvant of embolismic chemotherapy on primary hepatic carcinoma].

Objective: To evaluate the clinical efficacy and side effects of Shelian capsule (SLC) as adjuvant of embolismic chemotherapy on primary hepatic carcinoma.

Methods: One hundred and twenty patients with hepatic carcinoma were conducted arterial embolismic chemotherapy with FAM program for two therapeutic cycles. The 60 patients in the treated group were taken SLC orally for auxiliary treatment, and the other 60 in the control group were given glucurolactone instead.

[Differential visual attention scales directed by location versus semantic cue].

Objective: To compare the cortical mechanisms associated with visual spatial attention directed by location cues and Chinese character cues.

Method: Eleven healthy adults (mean age=19) with normal vision served as the subjects. In experiment I, the cue was a circle with black solid line.