Publications by authors named "Wen Zhao"

This study aims to mine the genes of Dendrobium officinale in response to high temperature stress and explore the molecular mechanism underlying the heat tolerance of D. officinale. In this study, the D.

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Oxidative stress, which results from an overproduction of reactive oxygen species (ROS), can cause damage that may contribute to a range of metabolic disorders. Antioxidants are considered to upregulate the activity of antioxidant enzymes, which are crucial for eliminating excess ROS and safeguarding the body against oxidative stress-induced damage. In the present study, the effect of polyphenol extracts from tartary buckwheat sprouts (TBSE) on the redox system of HepG2-cell-induced oxidative injury by hydrogen peroxide were investigated for evaluating the protective effect and mechanism of tartary buckwheat sprouts (TBS).

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Prolactin (PRL) has recently been found to play a role in lipid metabolism in addition to its traditional roles in lactation and reproduction. However, the effects of PRL on lipid metabolism in liver and adipose tissues are unclear. Therefore, we aimed to study the role of PRL on lipid metabolism in goats.

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Background: Systemic inflammation, as an important host property, is the most representative tumor-host interactions in cancer, and the development of malignant neoplasms may contribute to impairment on nutritional status. This study aimed to investigate the potential ability of nutritional and inflammatory index in predicting neoadjuvant chemoradiotherapy efficacy and prognosis in locally advanced rectal cancer (LARC).

Methods: This study was conducted using multi-institutional data.

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Xylan, a pivotal polymer with diversified structures, is indispensable for cell wall integrity and contributes to plant growth and biomass recalcitrance. Xylan is synthesized by multi-enzyme complexes named xylan synthase complexes (XSCs). However, the biochemical mechanism of XSCs and the functions of core components within XSC remain unclear.

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Article Synopsis
  • A universal stress protein (USP) family exists in a variety of species, including wheat, and is important for responding to different stress conditions such as heat and toxins.
  • Researchers discovered 88 USP genes in wheat and classified them into four distinct subfamilies, showing evolutionary conservation between monocots and dicots.
  • Experiments revealed that the TaUSP85 gene plays a crucial role in enhancing stress tolerance and silencing this gene led to adverse effects like wilting and increased damage in wheat plants, indicating the significance of USPs in plant stress responses.
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Background: It has been reported that COVID-19 patients have an increased risk of developing IBS; however, the underlying genetic mechanisms of these associations remain largely unknown. The aim of this study was to investigate potential shared SNPs, genes, proteins, and biological pathways between COVID-19 and IBS by assessing pairwise genetic correlations and cross-trait genetic analysis.

Materials And Methods: We assessed the genetic correlation between three COVID-19 phenotypes and IBS using linkage disequilibrium score regression (LDSC) and high-definition likelihood (HDL) methods.

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JOURNAL/nrgr/04.03/01300535-202510000-00024/figure1/v/2024-11-26T163120Z/r/image-tiff The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury. However, whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions, such as the cortex, remains unknown.

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  • Periventricular leukomalacia is commonly found in patients with spastic cerebral palsy and involves myelin damage that affects neuronal connectivity, particularly in infants.
  • This study compared grey matter alterations in 42 children with periventricular leukomalacia (divided into preterm and full-term) to 38 healthy controls using advanced brain imaging techniques.
  • Findings revealed that both groups had abnormal motor networks, with preterm infants showing greater atrophy in grey matter nuclei, while full-term infants had issues mainly in the motor cortex; connectivity changes between these brain regions also correlated with motor skill performance.
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Purpose: Colorectal cancer (CRC) is a common malignancy with a low survival rate as well as a low response rate to immunotherapy. This study aims to develop a risk model based on tertiary lymphoid structure (TLS)-associated gene signatures to enhance predictions of prognosis and immunotherapy response.

Methods: TLS-associated gene data were obtained from TCGA-CRC and GEO cohorts.

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Previous studies demonstrated that sufferers with halitosis can be significantly improved with ET-22 (ET-22) postbiotics intervention. The objectives of this investigation were to identify the primary components responsible for inhibiting oral malodor. This study demonstrated that cell-free supernatants (CFSs) were more effective in inhibiting production of volatile sulfur compounds (VSCs).

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Acoustic bioassembly is recently regarded as a highly efficient biofabrication tool to generate functional tissue mimics. Despite their capacity of directly patterning live cells with close intercellular proximity, most acoustic bioassembly techniques are currently limited to generate some specific simple types of periodic and symmetric patterns, which represents an urgent challenge to emulate geometrically complex cytoarchitecture in human tissue. To address this challenge, we herein demonstrate a soft-lithographically defined acoustic bioassembly (SLAB) technique that enables to assemble live cells into geometrically defined arbitrary multicellular structures.

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Unlabelled: Carbapenem-resistant hypervirulent (CR-hvKP) strains present a significant global public health threat due to their high mortality rates. This study investigated the genomic characteristics of seven ST11-K1 CR-hvKP isolates harboring highly homologous KPC-2-encoding multidrug-resistance plasmids. The strains were isolated from a Chinese tertiary hospital between 2017 and 2020.

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Background: Hippocampal Neuroinflammation (HNF) is a critical driver of cognitive impairment. The lipopolysaccharide (LPS) accumulate amyloid beta (Aβ) and lead to HNF. The (BL) 99 have anti-inflammatory ability.

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Microplastics (MPs) in subsurface environments are migratory and can carry heavy metals, increasing the extent of MP and heavy metal pollution. This study used quartz sand-filled column experiments to investigate the adsorption and cotransport behaviours of PS-MPs, O, UV-aged PS-MPs, and Cu at different MP concentrations, ionic strengths, and ionic valences in a saturated porous medium. The results showed that when MPs migrate alone in the absence of an ionic background, higher concentrations have increased mobility.

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Parkinson's disease (PD), as a refractory neurological disorder with complex etiology, currently lacks effective therapeutic agents. Natural products (NPs), derived from plants, animals, or microbes, have shown promising effects in PD models through their antioxidative and anti-inflammatory properties, as well as the enhancement of mitochondrial homeostasis and autophagy. The misfolding and deposition of α-Synuclein (α-Syn), due to abnormal overproduction and impaired clearance, being central to the death of dopamine (DA) neurons.

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Flaviviruses strategically utilize the endoplasmic reticulum (ER) in their replication cycles. However, the role of ER autophagy (ER-phagy) in viral replication process remains poorly understood. Here, we reveal that prolonged Zika virus (ZIKV) infection results from the degradation of ER-phagy receptor FAM134B, facilitated by viral NS2A protein.

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Lacticaseibacillus paracasei K56 (L. paracasei K56) is a probiotic with weight-loss effects. However, symbiosis research on the combined effects of Lacticaseibacillus paracasei K56 and prebiotics is lacking.

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Using density functional theory, we carefully calculated the relative stability of monolayer, few-layer, and cluster structures with Penta PdSe, T-phase PdSe, and PdSe-phase. We found that the stability of Penta PdSe increases with the number of layers. The Penta PdSe, T-phase PdSe, and PdSe monolayers are all semiconducting, with band gaps of 1.

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Article Synopsis
  • Secretomes from mesenchymal stem cells (MSCs) have great potential for future therapies, and optimizing biomaterial design can enhance stem cell effectiveness.
  • This study explored how 3D fibrous constructs with varying pore sizes influenced the mechanotransduction in adipose-derived MSCs (Ad-MSCs) and their paracrine functions.
  • Results showed that finer strand spacing (40 µm) improved the cytoskeleton organization and paracrine effects, leading to better skin regeneration in vivo, highlighting the importance of spatial cues in stem cell therapy.
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Background: Altered patterns of bile acids (BAs) are frequently present in liver fibrosis, and BAs function as signaling molecules to initiate inflammatory responses. Silybin meglumine (SLB-M) is widely used in treating various liver diseases including liver fibrosis. However, research on its effects on bile acid (BA) metabolism is limited.

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  • * A patient with LUSC was found to have a new FGFR3-IER5L fusion through next generation sequencing and opted for anlotinib treatment instead of conventional therapies like surgery or chemotherapy.
  • * Anlotinib, a multi-target tyrosine kinase inhibitor, led to a partial response in the patient, resulting in a progression-free survival of 3.8 months.
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