Two new Cd MOFs of 1,4-bis(1H-benzimidazol-1-yl)butane and flexible dicarboxylate ligands: luminescence sensing towards Fe.

Two new Cd MOFs, namely, two-dimensional (2D) poly[[[μ-1,4-bis(1H-benzimidazol-1-yl)butane](μ-heptanedioato)cadmium(II)] tetrahydrate], {[Cd(CHO)(CHN)]·4HO} or {[Cd(Pim)(bbimb)]·4HO} (1), and 2D poly[diaqua[μ-1,4-bis(1H-benzimidazol-1-yl)butane](μ-decanedioato)(μ-decanedioato)dicadmium(II)], [Cd(CHO)(CHN)(HO)] or [Cd(Seb)(bbimb)(HO)] (2), have been synthesized hydrothermally based on the 1,4-bis(1H-benzimidazol-1-yl)butane (bbimb) and pimelate (Pim, heptanedioate) or sebacate (Seb, decanedioate) ligands. Both MOFs were structurally characterized by single-crystal X-ray diffraction. In 1, the Cd centres are connected by bbimb and Pim ligands to generate a 2D sql layer structure with an octameric (HO) water cluster.

Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma.

Background: Abnormal activation of STAT3 and miR-21 plays a vital role in progression and invasion of solid tumors. The cyclin-dependent kinase 5 (CDK5) is reported to contribute to cancer metastasis by regulating epithelial-mesenchymal transition (EMT). However, the role of STAT3/miR-21 axis and CDK5 in head and neck squamous cell carcinoma remains unclear.

[Molecular basis and clinical transfusion of a family with Bw subtype of ABO blood group system].

Objective: To study a family with Bw subtype of ABO blood group system, and to review safety issues in relation with clinical transfusion.

Methods: The molecular basis for the blood type was studied with serological assay, polymerase chain reaction-sequence specific primer (PCR-SSP) and DNA sequencing, TA clone and haplotype analysis in one blood donor whose ABO blood group were difficulty typed and her family. The bioinformatics analysis was carried out by biological analysis software to investigate the change of structure and function of enzymes influenced by the change amino acid.

A copper chaperone for superoxide dismutase that confers three types of copper/zinc superoxide dismutase activity in Arabidopsis.

The copper chaperone for superoxide dismutase (CCS) has been identified as a key factor integrating copper into copper/zinc superoxide dismutase (CuZnSOD) in yeast (Saccharomyces cerevisiae) and mammals. In Arabidopsis (Arabidopsis thaliana), only one putative CCS gene (AtCCS, At1g12520) has been identified. The predicted AtCCS polypeptide contains three distinct domains: a central domain, flanked by an ATX1-like domain, and a C-terminal domain.