Synopsis of recent research by authors named "Wen Y Wu"
- Wen Y Wu's recent research primarily focuses on the mechanisms and evolutionary adaptations of CRISPR-Cas systems, particularly examining the structural and functional properties of various Cas nucleases, including Cas9, Cas12, and their derivatives.
- The studies highlight significant findings such as the identification of TnpB-like repressors that have evolved from transposon nucleases into RNA-guided transcriptional regulators, underscoring the evolutionary transitions within these molecular mechanisms.
- Wu's work also emphasizes the efficiency and trade-offs between different CRISPR systems in DNA targeting, revealing important differences in their search dynamics and cleavage mechanisms, with implications for genome editing technologies.
