Publications by authors named "Wen Ting Dai"

Article Synopsis
  • Epilepsy affects around 50 million people worldwide, with many patients facing drug-refractory conditions despite available anti-epileptic drugs, indicating a need for new treatment options.
  • This study investigates troglitazone (TGZ) as a potential neuroprotective agent against seizures and neuronal damage, employing both in vitro and in vivo models to assess its effects.
  • Results showed that TGZ significantly reduced seizure severity and neuronal damage by inhibiting ferroptosis, preventing mitochondrial changes, and demonstrating efficacy in both cell models of toxicity.
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To explore the pollution characteristics and source of soil heavy metal in a coal mine area near the Yellow River in Shandong, the geo-accumulation index method and improved Nemerow pollution index method were used to evaluate the pollution characteristics of soil heavy metal. The absolute principal component-multiple linear regression model (APCS-MLR) was used to quantitatively analyze the source of soil heavy metal, and the spatial distribution of Hg and Cd were analyzed using the Kriging spatial difference method in ArcGIS. The result accuracy of the APCS-MLR model was further verified.

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Atmospheric black carbon (BC), primary and secondary brown carbon (BrC and BrC) are the light-absorbing carbonaceous aerosol components. The vertical changes in the BC and BrC distributions are not generally known. Here, we presented a study of the spectral light absorption properties, direct solar absorption, and potential source areas of BC and BrC at the foothill (375 m a.

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Hepatocellular carcinoma (HCC) is a common and deadly malignancy worldwide. Current treatment methods for hepatocellular carcinoma have many disadvantages; thus, it is urgent to improve the efficacy of these therapies. Glycolysis is critical in the occurrence and development of tumors.

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Tumor metastasis is the major cause of tumor relapse and cancer-associated mortality in colorectal cancer, leading to poor therapeutic responses and reduced survival. eIF3a was previously described as an oncogene. However, its role in colorectal cancer progression and metastasis has not yet been fully investigated.

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The codling moth, L. (Lepidoptera, Tortricidae), is a serious invasive pest of pome fruits. Currently, management mainly relies on the application of insecticides, which have driven the development of resistance in the insect.

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Background: Triple negative breast cancer (TNBC) is a highly heterogeneous breast cancer subtype with a poor prognosis due to its extremely aggressive nature and lack of effective treatment options. This study aims to summarize the current hotspots of TNBC research and evaluate the TNBC research trends, both qualitatively and quantitatively.

Methods: Scientific publications of TNBC-related studies from January 1, 2010 to October 17, 2020 were obtained from the Web of Science database.

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Zijuan tea ( Camellia sinensis var. assamica), an anthocyanin-rich cultivar with purple leaves, is a valuable material for manufacturing tea with unique color and flavor. In this paper, four new phenylpropanoid substituted epicatechin gallates (pECGs), Zijuanins A-D (1-4), were isolated from Zijuan green tea by different column chromatography.

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The initiation and maintenance of lactation are complex phenomena governed by biochemical and endocrine processes in the mammary gland (MG). Although DNA-based approaches have been used to study the onset of lactation, more comprehensive RNA-based techniques may be critical in furthering our understanding of gene alterations that occur to support lactation in the bovine MG. To further determine how gene profiles vary during lactation compared with the dry period, RNA-seq transcriptomic analysis was used to identify differentially expressed genes (DEG) in bovine MG tissues from animals that were lactating and not lactating.

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Article Synopsis
  • Tumor-specific hepatic stellate cells (tHSCs) play a role in the progression of hepatocellular carcinoma (HCC) by influencing dendritic cells (DCs).
  • Co-culture with tHSCs increases DIgR2 expression in bone marrow-derived DCs, which depends on the activation of the MEK-ERK signaling pathway.
  • tHSCs also reduce cytokine production and induce T-cell hypo-responsiveness, leading to decreased activity of cytotoxic T lymphocytes, effects that can be reversed by silencing DIgR2 in DCs.
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Article Synopsis
  • Tumor-specific hepatic stellate cells (tHSCs) play a supportive role in the development and progression of hepatocellular carcinoma (HCC).
  • Previous research indicated that tHSCs promote the expression of DIgR2, a receptor that hinders immune responses initiated by dendritic cells (DCs).
  • The new study found that silencing DIgR2 with siRNA significantly reduced HCC growth in rats and enhanced the effectiveness of the chemotherapy drug 5-FU, while also increasing the activity of tumor-derived DCs (tDCs) by boosting their expression of key immune activation markers.
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Airborne carbonyls were characterized from emitted indoor coal combustion. Samples were collected in Xuanwei (Yunnan Province), a region in China with a high rate of lung cancer. Eleven of 19 types of samples (58%) demonstrated formaldehyde concentrations higher than the World Health Organization exposure limit (a 30-min average of 100 μg m).

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Unlabelled: A pilot hazardous airborne carbonyls study was carried out in Hong Kong and the Mainland of China. Workplace air samples in 14 factories of various types of manufacturing and industrial operations were collected and analyzed for a panel of 21 carbonyl compounds. The factories can be classified into five general categories, including food processing, electroplating, textile dyeing, chemical manufacturer, and petroleum refinery.

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Nanostructured lipid carriers (NLC) are a new generation of lipid nanoparticles, which are produced by controlled mixing of solid lipids with spatially incompatible liquid lipids leading to special nanostructures with improved drug incorporation and release properties. In this study, silybin-loaded nanostructured lipid carriers with various liquid lipid content were successfully prepared by the method of emulsion evaporation at a high temperature and solidification at a low temperature. The size and morphology of nanoparticles were significantly influenced by the liquid lipid content.

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