Regulation of Fuzheng Huayu capsule on inhibiting the fibrosis-associated hepatocellular carcinogenesis.

In the current study, bioinformatics analysis of the hepatocellular carcinoma (HCC) dataset was conducted with the hepatoprotective effect of the Fuzheng Huayu (FZHY) capsule against the diethylnitrosamine-induced HCC progression analyzed. Eight cell clusters were defined and , , and , compounds of the FZHY capsule, inhibit HCC progression-related fibrosis by regulating the expression of and . Combined with the ameliorative effect of the FZHY capsule against liver dysfunctions and expression of PLAU and IGFBP3, our study confirmed the effect of the FZHY capsule on inhibiting the fibrosis-associated HCC progression regulating the expression of PLAU and IGFBP3.

Detection of Cadmium in Human Biospecimens by a Cadmium-Selective Whole-Cell Biosensor Based on Deoxyviolacein.

Cadmium poses a severe health risk, impacting various bodily systems. Monitoring human exposure is vital. Urine and blood cadmium serve as critical biomarkers.

High-throughput screening of human mercury exposure based on a low-cost naked eye-recognized biosensing platform.

Whole-cell biosensors could be helpful for in situ disease diagnosis. However, their use in analyzing biological samples has been hindered by unstable responses, low signal enhancement, and growth inhibition in complex media. Here, we offered a solution by building a visual whole-cell biosensor for urinary mercury determination.

[Analysis of Formation Processes and Sources of PM Ammonium During Winter and Summer in Suburban Area of the Yangtze River Delta].

As the main pollutants of secondary inorganic aerosols(SIAs) in fine particulate matter(PM), aerosol ammonium(p-NH) plays a significant role in the formation of haze. However, the contribution ratio of each potential source of atmospheric NH(p-NH and NH) still remains controversial. In this study, 3 h high-frequency PM samples were collected in Dongshan, Suzhou during winter and summer in 2015, respectively.

Surface Functionalised Optical Fibre for Detection of Hydrogen Sulphide.

Dysregulated production of hydrogen sulphide in the human body has been associated with various diseases including cancer, underlining the importance of accurate detection of this molecule. Here, we report the detection of hydrogen sulphide using fluorescence-emission enhancement of two 1,8-naphthalimide fluorescent probes with an azide moiety in position 4. One probe, serving as a control, featured a methoxyethyl moiety through the imide to evaluate its effectiveness for hydrogen sulphide detection, while the other probe was modified with (3-aminopropyl)triethoxysilane (APTES) to enable direct covalent attachment to an optical fibre tip.

Evaluation of metoprolol standard dosing pathway in Chinese patients with acute coronary syndrome: a prospective multicenter single-arm interventional study.

Objective: To evaluate the feasibility and tolerability of metoprolol standard dosing pathway (MSDP) in Chinese patients with acute coronary syndrome (ACS).

Methods: In this multicenter, prospective, open label, single-arm and interventional study that was conducted from February 2018 to April 2019 in fifteen Chinese hospitals. A total of 998 hospitalized patients aged ≥ 18 years and diagnosed with ACS were included.

Performance of the PRISM I, PIM2, PELOD-2 and PRISM IV scoring systems in western China: a multicenter prospective study.

Background: The aim of this study was to evaluate the performance of the four scoring tools in predicting mortality in pediatric intensive care units (PICUs) in western China.

Methods: This was a multicenter, prospective, cohort study conducted in six PICUs in western China. The performances of the scoring systems were evaluated based on both discrimination and calibration.

A Decreased Absolute Number of T Cells in Patients with Active Rheumatoid Arthritis is Associated with Elevated Serum Osteopontin Levels with Disease Progression.

Introduction: Rheumatoid arthritis (RA) is a chronic and refractory autoimmune disease characterized by synovial inflammation with unknown aetiology. Immune system dysfunction mediated by CD4 T lymphocytes, which is regulated by the cytokine osteopontin (OPN), plays an important role in the pathogenesis of RA.

Methods: In this study, the levels of peripheral CD4 T subsets and serum OPN in patients with active RA were measured and analysed to determine the possible pathogenesis of RA and to provide potential therapeutic targets.

Serial and parallel convolutional neural network schemes for NFDM signals.

Two conceptual convolutional neural network (CNN) schemes are proposed, developed and analysed for directly decoding nonlinear frequency division multiplexing (NFDM) signals with hardware implementation taken into consideration. A serial network scheme with a small network size is designed for small user applications, and a parallel network scheme with high speed is designed for places such as data centres. The work aimed at showing the potential of using CNN for practical NFDM-based fibre optic communication.

Development of an optical fiber-based redox monitoring system for tissue metabolism.

An optical redox ratio can potentially be used to report on the dynamics of cell and tissue metabolism and define altered metabolic conditions for different pathologies. While there are methods to measure the optical redox ratio, they are not particularly suited to real-time in situ or in vivo analysis. Here, we have developed a fiber-optic system to measure redox ratios in cells and tissues and two mathematical models to enable real-time, in vivo redox measurements.

Formation Mechanisms and Source Apportionments of Airborne Nitrate Aerosols at a Himalayan-Tibetan Plateau Site: Insights from Nitrogen and Oxygen Isotopic Compositions.

Formation pathways and sources of atmosphere nitrate (NO) have attracted much attention as NO had detrimental effects on Earth's ecosystem and climate change. Here, we measured nitrogen (δN-NO) and oxygen (δO-NO and ΔO-NO) isotope compositions in nitrate aerosols at the Qomolangma station (QOMS) over the Himalayan-Tibetan Plateau (HTP) to quantify the formation mechanisms and emission sources of nitrate at the background site. At QOMS, the enhanced NO concentrations were observed in the springtime.

Direct decoding of nonlinear OFDM-QAM signals using convolutional neural network.

Nonlinear Fourier transform, as a technique that has a great potential to overcome the capacity limit in fibre optical communication system, faces speed and accuracy bottlenecks in practice. Machine learning using convolutional neural networks shows great potential in NFT-based applications. We have developed a convolutional neural network for decoding information in NFT-based communication and numerically demonstrated its performance in comparison to a fast NFT algorithm.

PPM1H is an independent prognostic biomarker of non-small cell lung cancer.

Protein phosphatase 1H (PPM1H) is the metal-dependent protein phosphatase, however, its role in tumorigenesis and tumor progression remains controversial. Non-small-cell lung cancer (NSCLC) is the most common histological type of lung cancer but the expression and clinical significance of PPM1H in NSCLC is unknown. In our study, we detected the mRNA of PPM1H in 25 pairs of NSCLC tissues and their corresponding adjacent tissues with qRT-PCR.

A correlation propagation model for nonlinear fourier transform of second order solitons.

Inverse scattering transform or nonlinear Fourier transform (NFT) has been proposed for optic communication to increase channel capacity beyond the well known Shannon limit. Within NFT, solitons, as discrete outputs of the transform, can be a type of resource to carry information. Second-order solitons as the most basic higher order solitons show correlations among their parameters in the nonlinear Fourier domain as they propagate along a fibre.

Development of a Monitoring System for Semicontinuous Measurements of Stable Carbon Isotope Ratios in Atmospheric Carbonaceous Aerosols: Optimized Methods and Application to Field Measurements.

Carbon content constitutes a major fraction of atmospheric particulate matter (PM) and directly influences the earth's climate and human health. The stable carbon isotope ratios (δC) can be used to track potential sources and atmospheric processes of carbonaceous aerosols. Previously, determination of δC was always conducted in offline carbonaceous aerosol samples.

Dysregulation of the Urothelial Cancer Associated 1 Long Noncoding RNA Promotes Proliferation of Vascular Smooth Muscle Cells by Modulating Expression of P27KIP1/CDK2.

Atherosclerosis is one of the leading causes of morbidity and mortality worldwide. A variety of long noncoding RNAs (lncRNAs) have been reported to be significantly involved in vascular smooth muscle cell (VSMC) proliferation, which is an essential process for atherosclerotic plaque formation. The aim of this study was to investigate the mechanism of lncRNA urothelial cancer associated 1 (UCA1) involvement in atherosclerosis.

MicroRNA-34c suppresses proliferation of vascular smooth muscle cell via modulating high mobility group box protein 1.

Background: Atherosclerosis is the most frequent pathological process that causes cardiovascular diseases.

Objective: The present study aimed to confirm miRNAs associated with atherosclerosis and explore the molecular mechanism of miR-34c and its target high mobility group box protein 1 (HMGB1) in the control of growth of smooth muscle cells in the development of atherosclerosis.

Methods: Real-time PCR was firstly performed to confirm miRNA correlation with atherosclerosis, and computational analysis and luciferase assay were performed to explore the target of miR-34c, Western blot, and real-time PCR were also utilized to reveal the effect of whether high glucose (HG) and miR-34c affect miR-34c, HMGB1 levels, NF-κB p65 and TNF-α levels, and the role of miR-34c on vascular smooth muscle cells (VSMCs) viability induced by HG.

Evaluation of silica and PMMA optical fibre response when irradiated with 16.5 MeV protons.

An investigation into the response of optical fibres to 16.5 MeV protons is presented here. A silica and a poly(methyl methacrylate) (PMMA) optical fibre was exposed to 16.

Correlated Eigenvalues of Multi-Soliton Optical Communications.

There is a fundamental limit on the capacity of fibre optical communication system (Shannon Limit). This limit can be potentially overcome via using Nonlinear Frequency Division Multiplexing. Dealing with noises in these systems is one of the most critical parts in implementing a practical system.

Femtosecond-laser-written Microstructured Waveguides in BK7 Glass.

There is a deficiency of low-loss microstructured waveguides that can be fabricated with a single laser-pass to minimize stress build-up, which can enable enhanced functionality and higher compactness for integrated optical devices. We demonstrate, for the first time, a series of multi-ring claddings each with a pair of cores in BK7 glass. Each waveguide was fabricated using only a single laser-pass at 1 MHz pulse repetition rate, 5 mm/s translation speed, 250 fs pulse width, over a set of pulse energies.

[Characteristics and Sources of Water Soluble Inorganic Ions in Fine Particulate Matter During Winter in Xuzhou].

A total of 32 daily PM samples were collected from December 2016 to February 2017 in the urban area of Xuzhou city. Water-soluble inorganic ions (WSⅡs), including F, Cl, NO, SO, Na, Mg, NH, K and Ca, were determined by ion chromatography. The average mass concentration of PM was (164.

[Characteristics and Source Analysis of Carbonaceous Components of PM During Autumn in the Northern Suburb of Nanjing].

In this study, PM samples were collected from October to November of 2015 in the northern suburb of Nanjing. The mass concentrations of organic carbon (OC), elemental carbon (EC), and levoglucosan in the samples were analyzed by thermal optical transmittance (TOT) and ion chromatography. The average concentrations of OC and EC were respectively (11.

Synchronised dual-wavelength mode-locking in waveguide lasers.

We present a novel approach to study continuous-wave mode-locking in a waveguide laser in the presence of a gain profile with complex features. We introduce a new simulation approach where we separate the role of gain, nonlinearity, dispersion and saturable absorption elements to provide a better understanding of the interplay between these elements. In particular, we use the simulation to explain synchronised dual-wavelength mode-locking.

Heterologous Expression of the Cotton NBS-LRR Gene Enhances Verticillium Wilt Resistance in .

Verticillium wilt caused by results in severe losses in cotton, and is economically the most destructive disease of this crop. Improving genetic resistance is the cleanest and least expensive option to manage Verticillium wilt. Previously, we identified the island cotton NBS-LRR-encoding gene that confers resistance to the highly virulent isolate Vd991.

Comparative genomics reveals cotton-specific virulence factors in flexible genomic regions in Verticillium dahliae and evidence of horizontal gene transfer from Fusarium.

Verticillium dahliae isolates are most virulent on the host from which they were originally isolated. Mechanisms underlying these dominant host adaptations are currently unknown. We sequenced the genome of V.