Association analyses between the variants of , and and the efficacy of botulinum toxin A in the treatment of the primary Meige syndrome.

Objective: Individual differences were observed in the clinical efficacy of Botulinum toxin A (BoNT-A) in the treatment of the primary Meige syndrome. Our study aimed to explore the potential associations between the clinical efficacy of BoNT-A in the treatment of the primary Meige syndrome and variants of , and , which are involving in the translocation of the BoNT-A in vivo.

Methods: Patients with the primary Meige syndrome treated with BoNT-A were enrolled.

Mechanism of Polysaccharides in Inhibiting Hyperoxalate-Induced Renal Injury and Crystal Deposition.

Oxidative damage to the kidneys is a primary factor in the occurrence of kidney stones. This study explores the inhibitory effect of polysaccharides (PYP) on oxalate-induced renal injury by detecting levels of oxidative damage, expression of adhesion molecules, and damage to intracellular organelles and revealed the molecular mechanism by molecular biology methods. Additionally, we validated the role of PYP in vivo using a crystallization model of hyperoxalate-induced rats.

A clinical predictive model for pre-transplantation colonization and relevance for clinical outcomes in patients receiving allogeneic hematopoietic stem cell transplantation.

The purpose of this study is to establish a clinical prediction model to discriminate patients at high risk of (KP) colonization before allogeneic hematopoietic stem cell transplantation (allo-HSCT) and evaluate the impact of KP colonization on clinical outcomes after allo-HSCT. We retrospectively collected data from 2,157 consecutive patients receiving allo-HSCT between January 2018 and March 2022. KP colonization was defined as a positive test for KP from a pharyngeal or anal swab before allo-HSCT.

Risk Factors for Carbapenem-Resistant Colonization and the Effect on Clinical Outcomes and Prognosis in Allogeneic Hematopoietic Stem Cell Transplanted Patients.

Purpose: The current study assesses which are the main risk factors, clinical outcome and prognosis following the colonization of CRE in patients that underwent allo-HSCT.

Patients And Methods: A total of 343 patients subjected to allo-HSCT in the period comprised between June 2021 and June 2022 were enrolled in this retrospective study. The CRE colonization was diagnosed by clinical history and routine microbial culture of perirectal swab.

Association of Decreased Serum BDNF With Restless Legs Syndrome in Parkinson's Disease Patients.

To objective of the study was to investigate whether serum brain-derived neurotrophic factor (BDNF) levels are associated with the severity of restless legs syndrome (RLS) in Parkinson's disease (PD). A total of 249 PD patients with ( = 53) and without RLS ( = 196) and 326 age-matched controls were included in this study. All the serum BDNF levels of the participants were measured.

Theoretical investigation of the low lying electronic states of MgGa.

In this work, we investigate the low-lying electronic states correlated to the first and the second dissociation channels of MgGa molecule, neglecting and including the spin-orbit coupling effect. High-level ab initio calculations have been performed by using the icMRCI + Q method. Potential energy curves, spectroscopic constants, electron configurations and dipole moments are derived and discussed.

[Contributions of Emissions Reduction and Regional Meteorological Conditions to Air Quality Improvement].

Regional meteorological conditions and emissions reduction are closely related to air quality. China has a monsoonal climate and regional meteorological conditions are significantly impacted by interannual climate variability. The objective of this study was to evaluate the contributions of meteorological conditions and emissions reduction to regional improvements in air quality.

Revolution spectral CT for urinary stone with a single/mixed composition in vivo: a large sample analysis.

Purpose: To analyze various compositions of urinary stones using revolution spectral CT (rapid kV switching dual-energy CT) in vivo.

Methods: 202 patients with urinary stones underwent spectral CT before surgery. Zeff peak, overall scope and CT values were detected.

Low absolute neutrophil count during induction therapy is an adverse prognostic factor in childhood acute lymphoblastic leukaemia.

Variation in normal blood cells during chemotherapy has not been recognised as a risk factor guiding chemotherapy in childhood acute lymphoblastic leukaemia (ALL). This study aims to explore whether variations in normal haematopoiesis determine prognosis as well as to improve risk-stratified treatment in childhood ALL. A retrospective study of 279 cases of ALL treated with the CCCG-ALL-2015 regimen in the Division of Pediatric Blood Diseases Center, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, from May 2015 to January 2017 was performed to analyse the prognostic impact of blood cell levels on day 19 of induction therapy by Kaplan-Meier method.

[Characterization of Metal Pollution of Regional Atmospheric PM and Its Sources Based on the PMF Model].

As important components of PM, metal elements are extremely harmful to people and also have source specificity. Understanding the characteristics of PM metal pollution in the two different types of cities can help adjust the layout of regional industrial structure and improve the environment. PM samples during haze/non-haze periods were collected in Chengdu City and Renshou County.

Theoretical investigation on the low-lying electronic states of diatomic magnesium bismuthide including the spin-orbit coupling effect.

High-level ab initio computations have been performed to investigate molecular structures, potential energy curves, vibrational energy levels and spectroscopic constants for twelve Λ-S states of the first four dissociation limits of MgBi. Characterizations of seven Ω states, corresponding to the first and the second Λ-S dissociation limits, have been explored for the first time. The spin-orbit coupling effect is revealed to have introduced a significant impact on the pattern of these electronic states and interactions among them.

A Homozygotic Mutation in may Cause Keratinization Disorders and Thrombocytopenia: A Case Report.

Pathogenic mutations in 3-keto-dihydrosphingosine reductase (KDSR) gene are associated with keratinization disorders and impaired platelet function. However, no case with both homozygotic mutation of and hepatic hemangioendothelioma has ever been reported due to its low prevalence. Here we report a seven months old Chinese boy with a homozygotic missense mutation in and both of his parents carry a same heterozygous mutation.

[Clinical features and prognosis of core binding factor acute myeloid leukemia in children].

Objective: To study the clinical features and prognosis of core binding factor acute myeloid leukemia (CBF-AML) in children.

Methods: A retrospective analysis was performed from the chart review data of children who were newly diagnosed with CBF-AML in the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, from August 2009 to November 2015. According to the type of fusion gene, the children were divided into CBFB-MYH11 and AML1-ETO groups.

[Comparative Analysis of Pollution Characteristics of Carbonaceous Aerosol Components in the Atmosphere Between Urban and Suburban Areas].

To compare the pollution characteristics of carbonaceous aerosol components in the atmosphere between urban and suburban areas, Chengdu City and Renshou County were selected as study areas from which 88 samples of PM during haze and non-haze periods were collected and analyzed. Quantification of mass concentrations of PM, carbonaceous aerosol components[organic carbon (OC), elemental carbon (EC), and secondary organic carbon (SOC)], along with correlation analysis of OC and EC, and principal component analysis (PCA) of carbon components were carried out. The results show that pollutant concentrations during the haze period were higher than those during the non-haze period.

[Navitoclax Combined with Daunorubicin Promotes Apoptosis of Erythroleukemia Cell Lines K562, HEL and TF-1].

Objective: To study the effect of apoptotic drug Navitoclax (NTX) combined with chemotherapy drug Daunorubicin (DNR) on apoptosis of erythroleukemia cells.

Methods: K562, HEL and TF-1 cells in logarithmic growth phase were treated with NTX, DNR and combination of the two drugs. CCK-8 test, Annexin V-DAPI double-staining flow cytometry, real-time RT-PCR were used to detect cell growth, cell apoptosis and expression of BAX, BAK, BCL-2, BCL-xl and BIM respectively.

[Efficacy and prognostic factors in children with non-core binding factor acute myeloid leukemia].

Objective: To compare the efficacy of the CAMS-2005 and CAMS-2009 regimens in treating children with non-core binding factor acute myeloid leukemia (non-CBF AML) and to study the prognosis factors.

Methods: A total of 161 children who were initially diagnosed with non-CBF AML from April 2005 to December 2015 were enrolled as study subjects, and were divided into a CAMS-2005 regimen group (n=52) and a CAMS-2009 regimen group (n=109) according to the chemotherapy regimen provided. The efficacy was retrospectively compared between the two groups.

Theoretical study of the low-lying electronic states, including the spin-orbit interactions, of the sulfur monochloride cation.

High-level ab initio computations have been performed on the experimentally unknown species SCl. The low-lying Λ-S electronic states correlated to the first and the second dissociation channels as well as their corresponding Ω states have been investigated by the icMRCI+Q methodology employing basis sets up to quintuple-ζ quality. Information about potential energy curves, electron configurations, spectroscopic constants, dipole moments and transition properties are derived and discussed.

[Identification of honeysuckle powder quality by Heracles Ⅱ ultra-fast gas phase electronic nose].

The quality of honeysuckle has always been an important factor in industrial development. Flowering is one of the elements for the variation of the effective components in honeysuckle. We can conveniently recognize whether the commodity is mixed with blossomed honeysuckle in the form of medicinal material.

[Clinical features of Wiskott-Aldrich syndrome: an analysis of 13 cases].

Objective: To study the clinical features of Wiskott-Aldrich syndrome (WAS) in children.

Methods: A retrospective analysis was performed for the clinical data of 13 children with WAS.

Results: All 13 children were boys, with a median age of onset of 3 months (range 1-48 months) and a median age of 24 months (range 1-60 months) at the time of diagnosis.