Publications by authors named "Wen Q Qiu"
Article Synopsis
- Fatty livers are often used in liver transplants, but they can be damaged and lead to cancer coming back.
- Researchers studied how certain cells (MDSCs) react during this injury and how fat affects them, particularly a process called NLRP3 inflammasome activation.
- They found that a fat called arachidonic acid activates NLRP3 in MDSCs, leading to more cancer recurrence, but blocking a specific protein (FATP2) can help prevent this problem.
Hepatocellular carcinoma (HCC) recurrence after liver transplantation remains a significant clinical problem. Ischemia-reperfusion injury (IRI) occurred inevitably at the early phase after liver transplantation (LT) spawns a significant risk of HCC recurrence. However, their linkage and IRI-derived risk factors for HCC recurrence remain exclusive.
View Article and Find Full Text PDFThe Sez6 family consists of Sez6, Sez6L, and Sez6L2. Its members are expressed throughout the brain and have been shown to influence synapse numbers and dendritic morphology. They are also linked to various neurological and psychiatric disorders.
View Article and Find Full Text PDFChemoresistance is the main cause of chemotherapy failure in patients with hepatocellular carcinoma (HCC). The gene encoding transmembrane protein 47 (TMEM47) was previously identified to be significantly upregulated in HCC cell lines with acquired chemoresistance. The aim of the present study was to characterize the clinical significance and function of TMEM47 in HCC chemoresistance.
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- Multiple sclerosis (MS) involves inflammation and degeneration in the central nervous system (CNS), impacting both grey and white matter, with significant grey matter changes observed in experimental models like MOG experimental autoimmune encephalomyelitis (EAE).
- In EAE, there is increased production of complement proteins, particularly C1q and C3, which are linked to synapse loss and microglial activation.
- Genetic knockout of C3 in mice was found to protect against synapse loss and reduce disease severity and memory impairment, indicating that the early complement pathway plays a critical role in grey matter pathology in EAE.
Microglial activation, increased proinflammatory cytokine production, and a reduction in synaptic density are key pathological features associated with HIV-associated neurocognitive disorders (HAND). Even with combination antiretroviral therapy (cART), more than 50% of HIV-positive individuals experience some type of cognitive impairment. Although viral replication is inhibited by cART, HIV proteins such as Tat are still produced within the nervous system that are neurotoxic, involved in synapse elimination, and provoke enduring neuroinflammation.
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