Publications by authors named "Wen Po Feng"
Therapeutic efficacy of solid tumor is often severely hampered by poor penetration of therapeutics into diseased tissues and lack of tumor targeting. In this study, the functionalized upconversion nanoparticles (UCNP)-based delivery vector targeting cancer cells was developed. Firstly, NaYF₄:Yb/Tm (UCNP) was prepared with the solvothermal method for the uniform nanoparticle size and brilliant lattice structure.
View Article and Find Full Text PDFAs a widely used first-line chemotherapy drug for tumor, Doxorubicin (DOX) can induce various side effects on normal tissues because of its non-specific distribution in the body. Emerging evidence has shown that platelets have the capability to recognize and interact with tumor cells. Inspired by this, the platelet-based drug delivery system was constructed by loading of DOX in platelet cytoplasm and modification of transferrin on the surface of platelet (Tf-P-DOX).
View Article and Find Full Text PDFArticle Synopsis
- Testosterone levels in mouse Leydig cells decreased due to exposure to T-2 toxin, but the effects of l-arginine on this reduction were unclear.
- Leydig cells were treated with various concentrations of l-arginine alongside T-2 toxin, leading to analysis of certain enzymes and proteins involved in testosterone production.
- The study found that l-arginine not only boosted testosterone levels affected by T-2 toxin but also enhanced the expression and activity of key enzymes (P450scc, 3β-HSD-1, and StAR) involved in steroid hormone synthesis.