Publications by authors named "Wen Ni Tiong"
Background: Diagnosing acute coronary syndrome (ACS) remains a challenge in patients presenting at early phase of hospitalization. We hypothesized that inflammatory markers of plaque rupture could accurately identifying ACS patients from stable coronary artery diseases (CAD).
Materials And Methods: The serum and peripheral blood gene expression levels of C-reactive protein (CRP) and von Willebrand factor (vWF) in multiethnic Malaysian patients (n = 7) admitted with early hospitalization of ACS was evaluated.
Article Synopsis
- This study investigates the prevalence and effect of CYP2C19 genetic variations on how Malaysian patients respond to clopidogrel, a common antiplatelet medication, particularly among those undergoing percutaneous coronary intervention.
- Conducted at Sarawak General Hospital, the research involved genotyping patients and assessing their platelet aggregation response to determine differences based on ethnicity and genetic profile.
- Results indicated that poor metabolisers, especially from the Chinese ethnic group, exhibited the highest resistance to clopidogrel, which highlights the potential for personalized medicine approaches based on genetic testing.
Objective: Interleukin-6 (IL6; proinflammatory marker), von Willebrand Factor (vWF; endothelial dysfunction marker) and P-selectin (platelet activation marker), may play important roles in defining the pathogenesis of vulnerable plaques in acute coronary syndrome (ACS). This study aims to investigate the expression and relationship of these markers in early phases of ACS in a young and multiethnic Malaysian population.
Design: Peripheral whole blood mRNA, and serum levels of IL6, vWF and P-selectin were measured in 22 patients with ACS, and in 28 controls with angiographically significant coronary artery disease without previous ACS events.