THE ASSOCIATION BETWEEN SHIFT WORK AND LIPID HEALTH IN CHINESE RAILWAY WORKERS: A LONGITUDINAL ANALYSIS OF 6 YEARS.

Objective: This study aimed to evaluate the longitudinal association between shift work and lipid health among railway workers.

Methods: Data from 1,126 railway workers with at least two physical examinations from 2016 to 2021 were retrieved. Records of triglycerides, total cholesterol, low-density and high-density lipoprotein cholesterol were extracted, with dyslipidemia defined by Chinese guidelines.

Nitrogen conversion and mechanisms related to reduced emissions by adding exogenous modified magnesium ore during aerobic composting.

In this study, modified products with a higher specific surface area and pore volume were prepared by light burning magnesite (MS) to increase its magnesium content and surface activity. MS heated at 650 °C (MS650) was applied in aerobic composting to assess its effect on nitrogen transformation during composting and the possible related chemical and microbial mechanisms. Adding MS650 reduced the NH emissions (0.

Comparative efficacy of intrauterine infusion treatments for recurrent implantation failure: a network meta-analysis of randomized controlled trials.

Objective: Recurrent implantation failure (RIF) is a significant challenge in assisted reproductive technology (ART), affecting many women undergoing in vitro fertilization (IVF). This study aims to compare the efficacy of various intrauterine infusion treatments, including granulocyte colony-stimulating factor (G-CSF), platelet-rich plasma (PRP), human chorionic gonadotropin (HCG), and peripheral blood mononuclear cells (PBMCs), in improving clinical pregnancy rate (CPR), live birth rate (LBR), and miscarriage rate (MR) in women with RIF.

Methods: A comprehensive search was conducted in multiple databases, including Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Embase, Web of Science, and China National Knowledge Internet (CNKI), to identify randomized controlled trials (RCTs) evaluating the efficacy of intrauterine infusion treatments for RIF.

Efficacy and safety of fruquintinib combined with PD-1 inhibitors in the treatment of refractory metastatic colorectal cancer: a systematic review and meta-analysis.

Background: Fruquintinib, a VEGFR1-3 tyrosine kinase inhibitor, is approved for treating refractory metastatic colorectal cancer. Recent clinical practice has shown that combining fruquintinib with programmed cell death protein 1 (PD-1) inhibitors can achieve better efficacy.The objective of this study is to assess the efficacy and safety of combining PD-1inhibitors with fruquintinib.

Multipoint Aspiration Technique Improves Hematoma Evacuation Efficiency and Functional Outcomes in Stereotactic Catheter Aspiration for Spontaneous Intracerebral Hemorrhage.

Introduction: The present study aimed to compare hematoma evacuation efficiency between multipoint and single-point aspiration techniques, and to investigate the influence of distinct aspiration techniques on functional outcomes in patients undergoing stereotactic catheter aspiration for intracerebral hemorrhage (ICH).

Methods: Clinical and imaging data from 102 consecutive patients diagnosed with ICH who underwent stereotactic catheter aspiration and thrombolysis were collected. Multivariate regression analyses were performed to evaluate the effects of catheter aspiration techniques on residual hematoma volume after aspiration alone (post-aspiration volume), residual hematoma volume at the end of treatment (EOT volume), and functional independence at 6 months (modified Rankin Scale score ≤ 2).

Potentiating anti-tumor immunity by re-engaging immune synapse molecules.

The formation of immune synapses (ISs) between cytotoxic T cells and tumor cells is crucial for effective tumor elimination. However, the role of ISs in immune evasion and resistance to immune checkpoint blockades (ICBs) remains unclear. We demonstrate that ICAM-1, a key IS molecule activating LFA-1 signaling in T and natural killer (NK) cells, is often expressed at low levels in cancers.

T- and pH-Dependent Hydroxyl-Radical Reaction Kinetics of Lactic Acid, Glyceric Acid, and Methylmalonic Acid in the Aqueous Phase.

Carboxylic acids are a common class of compounds found in atmospheric aerosols and cloud droplets. In this study, the oxidation kinetics of several carboxylic acids in the aqueous phase by the atmospherically relevant OH radical were investigated to better understand the loss processes for this class of compounds. The rate constants for the reactions of the OH radical were determined using the thiocyanate competition kinetics method for lactic acid, glyceric acid, and methylmalonic acid as a function of temperature and pH.

A deep ensemble learning framework for glioma segmentation and grading prediction.

The segmentation and risk grade prediction of gliomas based on preoperative multimodal magnetic resonance imaging (MRI) are crucial tasks in computer-aided diagnosis. Due to the significant heterogeneity between and within tumors, existing methods mainly rely on single-task approaches, overlooking the inherent correlation between segmentation and grading tasks. Furthermore, the limited availability of glioma grading data presents further challenges.

Risk factors for postoperative acute kidney injury after cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: a meta-analysis and systematic review.

Background: Acute kidney injury after CRS + HIPEC is a serious postoperative complication, but only a few studies have reported its postoperative risk factors. In addition, there are large discrepancies in the results of available observational studies.

Methods: We searched The Cochrane Library, Embase, Web of Science,and PubMed to identify observational studies reporting risk factors for AKI after CRS + HIPEC.

Impacts of polyglycolic acid and analogues on glycolipid metabolism and circadian behavior in zebrafish.

For the past few years, new biodegradable polymers, such as polyglycolic acid (PGA) and polylactic acid (PLA), have been promising materials to solve the remarkable environmental issue, of microplastics (MPs) pollution. In this research, the impacts of five MPs, including PGA, PLA, polybutylene succinate (PBS), polyhydroxyalkanoate (PHA), and polybutylene adipate terephthalate (PBAT), were analyzed on zebrafish with different concentrations. We found that PGA and PLA at 1 mg/L did not have obvious effects on liver function, glucose level, and circadian rhythm in larvae.

The effect of population density on the phenotype, metabolic and immunological adaptations in the cuticle of Spodoptera litura larvae.

Background: Species that experience outbreaks and those that display density-dependent phase polymorphism demonstrate density-dependent prophylaxis (DDP) by increasing their immune investment in response to increasing densities. Despite this phenomenon, the mechanisms of DDP remain largely unexplored.

Results: Here, we showed that Spodoptera litura exhibited heightened cuticular melanization and enhanced cuticular immune responses when reared at higher population density.

Biomechanical effects of saddle height changes in leisure cycling with unilateral transtibial prostheses: A simulated study.

Cycling is a beneficial physical activity for rehabilitating individuals with lower-limb amputations and serves as a feasible leisure sport. However, the optimal bicycle configuration for cycling with a unilateral transtibial prosthesis at leisure levels has not been investigated. For saddle height at professional cycling levels, existing literature suggests utilizing the same configuration as that used by intact cyclists, where the knee reaches 25-35° at maximum extension.

Causality between insulin use and malignant tumors of the digestive system: a two-sample mendelian randomized study.

Background: Existing cohort studies show no association between insulin use and cancers of the digestive system, while numerous meta-analyses suggest that insulin use increases the risk of digestive system tumours. This study uses two-sample Mendelian randomization (MR) to further investigate the causal relationship between the two.

Methods: We selected single nucleotide polymorphisms (SNPs) strongly associated with insulin use as instrumental variables and used aggregated statistics on digestive system neoplasms as the outcome event.

HERV reactivation by adenovirus infection is associated with viral immune regulation.

Human endogenous retroviruses (HERVs), which are normally silenced by methylation or mutation, can be reactivated by a variety of environmental factors, including infection with exogenous viruses. In this work, we investigated the transcriptional activity of HERVs following infection of human liver cells (HepaRG) with human adenovirus C serotype 5 (HAdV-C5). HAdV-C5 infection results in reactivation of several HERV groups as well as differentially expressed genes.

Environmental release behavior, cell toxicity and intracellular distribution of novel biodegradable plastic materials.

In response to the increasingly severe issue of plastic waste, biodegradable plastics have garnered extensive attention as a potential alternative to traditional plastics. Among these materials, biodegradable plastics hold a dominant position. The objective of this study was to assess the environmental risks of five commercially available biodegradable plastics: polyglycolic acid (PGA), polylactic acid (PLA), poly(butylene succinate) (PBS), poly(butylene carbonate) (PBC), and poly(butylene adipate-co-terephthalate) (PBAT).

Lyophilized T Cell Reference Materials with Quantified Proportions of Subtypes.

The accurate quantification of T cell subtypes and their proportions is of great significance in cell-based biomanufacturing, diagnosis, and advanced therapy. The development and application of a cell reference material (RM) provide a solid foundation for reliable and consistent T cell quantification worldwide. However, creating a cell RM that is both accurate and practical remains a challenge.

Prediction of cardiac deterioration in acute heart failure patients: Evaluation of the efficacy of single laboratory indicator models versus comprehensive models.

This study aims to compare the efficacy of single-indicator models versus comprehensive models in predicting cardiac deterioration events in patients with acute heart failure (AHF), providing a more precise predictive tool for clinical practice. This retrospective cohort study included 484 patients with AHF treated at our hospital between June 2018 and January 2023. Patients were categorized into a deterioration group and a non-deterioration group based on the occurrence of cardiac deterioration events within 1 year, defined as cardiogenic shock, cardiac arrest, or the need for mechanical circulatory support.

Metagenomic insights on promoting the removal of resistome in aerobic composting pig manure by lightly burned modified magnesite.

The antibiotic resistance genes (ARGs) have become a serious issue facing public health. In this study, light-burned magnesite with a high specific surface area at 650 °C (MS650) was used for aerobic composting, evaluating its effect on the resistome during pig manure composting. Different concentrations of MS650 reduced the abundance of the resistome, including seven high-risk ARGs, class two metal and biocide resistance genes (MBRGs), and human pathogenic bacteria (HPBs).

Extraction mechanism and bio-activities of capsaicinoids from lantern peppers placenta using deep eutectic solvents.

This study proposed ultrasound-assisted deep eutectic solvent (DES) for the extraction of capsaicinoids (CAP) from the placenta of lantern peppers. The DES of choline chloride-citric acid (ChCl-CA), with the highest CAP yield (8.25 mg/g) was screened.

A myeloid differentiation-like protein in partnership with Toll5 from the pest insect senses baculovirus infection.

Many types of viruses infect insects and other arthropods. In contrast, little is known about how arthropods sense viruses, although several innate immune pathways including Toll have antiviral functions. Large DNA viruses in the family are used to control a number of pest insects.

SCREENING AND MONITORING OF DIABETIC RETINOPATHY IN COMMUNITY CARE: The Effectiveness of Single-Field Versus Multifield Fundus Photography.

Purpose: This study aimed to evaluate the effectiveness of single-field fundus photography for diabetic retinopathy (DR) screening and monitoring versus six-field imaging in community settings.

Methods: Adults aged ≥30 years with Type 2 diabetes from 15 communities in Northeast China were recruited for this prospective cohort study (n = 2,006 at baseline and n = 1,456 at follow-up). Participants underwent both single-field and six-field digital fundus photography at baseline and follow-up visits (mean duration of 21.

Prediction of Kirsten rat sarcoma () mutation in rectal cancer with amide proton transfer-weighted magnetic resonance imaging.

Background: Kirsten rat sarcoma () mutation drives resistance to anti-epidermal growth factor receptor (anti-EGFR)-targeted therapies in rectal cancer. Amide proton transfer-weighted magnetic resonance imaging (APTw MRI) might be a supplement to the evaluation of mutation because the APTw value can reflect mobile cellular protein content . This study aimed to determine whether APTw MRI could predict mutation in rectal cancer and compare this technique with diffusion-weighted imaging (DWI).