Synthesis, biological and molecular docking studies of pyrimidine-derived bioactive Schiff bases.

Pyrimidine which is an important constituent of the genetic material of deoxyribonucleic acid, is identified with a large number of biological activities. Based on this, pyrimidine-derived Schiff bases (1-6) of hydroxy-1-naphthaldehyde were synthesized by using the condensation method. In addition, the molecular docking studies against topoisomerase II DNA gyrase, human hematopoietic cell kinase, urate oxidase from Aspergillus flavus, and cyclin-dependent kinase 8 to explore the antibacterial, antioxidant, antifungal, and anticancer properties respectively and binding affinities through bioinformatics approaches to determine the interaction among active molecules with the receptor.

Contemplating the necessity of surgical treatment for posterior lenticonus: a case report.

Background: Posterior lenticonus is an uncommon congenital abnormality that causes a progressive, localized spherical or conical bulging of the posterior capsular membrane, resulting in an abnormal shape of the lens.

Case Presentation: A 13-year-old girl presented with ametropia in both eyes. After mydriasis, examination revealed an oval bubble-shaped alteration with a distinct boundary above the temporal region on the center of the posterior capsule of her left lens.

Splicing oxygen-rich multidentate ligands and characteristic metals to construct flame colorants: abundant structures and attractive colors.

Tetranitroethane (TNE), an energetic compound with high-nitrogen (N%, 26.7%) and oxygen (O%, 60.9%) content, is deprotonated by alkali and alkaline earth metal bases to form the corresponding metal salts of TNE which are characterized by FT-IR spectroscopy, elemental analysis, and single crystal X-ray diffraction.

Synthesis, Crystal Structure, and Characterization of Energetic Salts Based on 3,5-Diamino-4-Pyrazol-4-One Oxime.

In order to broaden the study of energetic cations, a cation 3,5-diamino-4-pyrazol-4-one oxime (DAPO) with good thermal stability was proposed, and its three salts were synthesized by a simple and efficient method. The structures of the three salts were verified by infrared spectroscopy, mass spectrometry, elemental analysis, and single crystal X-ray diffraction. The thermal stabilities of the three salts were verified by differential scanning calorimetry and thermos-gravimetric analysis.

Energetic bimetallic complexes as catalysts affect the thermal decomposition of ammonium perchlorate.

Two bimetallic complexes of 4-hydroxy-3,5-dinitropyrazole, [KMn(DNPO)(HO)]·2HO (BMEP-1) and [KZn(DNPO)(HO)] (BMEP-2), were synthesized and characterized by IR spectroscopy and elemental analysis. The crystal structures of BMEP-1 and BMEP-2 were determined by single-crystal X-ray diffraction. It is noteworthy that these complexes presented different metal-organic frameworks.

Synthesis and characterization of promising insensitive energetic salts based on 3-amino-5-hydrazinopyrazole.

The development of green energetic materials is based on environmental friendliness, safety and performance improvement. It is of great significance to design and synthesize new nitrogen rich salts for a new generation of green energetic materials. In the present work, a series of 3-amino-5-hydrazinopyrazole energetic salts comprising energetic anions were synthesized and were characterized using elemental analysis, IR spectroscopy and differential scanning calorimetry (DSC).

Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing Fertilization and Embryo Transfer: A Large Retrospective Cohort Study.

Objective: Prior pulmonary tuberculosis (PTB) on chest X-ray (CXR) was commonly found in infertile patients receiving examinations before fertilization and embryo transfer (IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after IVF-ET.

Method: We conducted a retrospective cohort study of 14,254 infertile patients who had received IVF-ET at Peking University Third Hospital in 2017.

[Antithrombotic effects of recombinant hirudin in mice and its mechanism].

Objective: To investigate the antithrombotic effects of recombinant hirudin and its mechanism.

Methods: Sixty male Kunming mice were randomly divided into 6 group (=10):control group, model group, aspirin (25 mg/kg) group, recombinant hirudinlow, middle and high dose (0.05, 0.

Vitamin D deficiency and the risk of tuberculosis: a meta-analysis.

Background And Aim: To conduct meta-analyses of all published studies on various aspects of association between vitamin D and tuberculosis (TB).

Methods: PubMed and Web of Knowledge were searched for all properly controlled studies on vitamin D and TB. Pooled odds ratio, mean difference or standardized mean difference, and its corresponding 95% confidence interval were calculated with the Cochrane Review Manager 5.

A decision-tree model for predicting extubation outcome in elderly patients after a successful spontaneous breathing trial.

Background: The commonly used single tests, based on a 1-time measurement of a physiologic variable, are often poorly predictive of tracheal extubation outcome because they examine only a single aspect of physiological function that affects the extubation outcome. We hypothesized that the construction of a decision-tree model, which includes multiple variables and considers the changes of these variables, may more accurately predict successful extubation.

Methods: This was a prospective observational study.

[Physiologic response to external positive end-expiratory pressure in mechanically ventilated chronic obstructive pulmonary disease patients].

Objective: To evaluate the effects of external positive end-expiratory pressure (PEEPe) on respiratory system mechanics in passively ventilated chronic obstructive pulmonary disease (COPD) patients.

Methods: Fifteen patients with acute exacerbation of COPD were randomly enrolled into the study. The patients were admitted into respiratory intensive care unit (RICU) from Jan, 2005 to Jun, 2006 for controlled mechanical ventilation.

[Radar radiation damages sperm quality].

Objective: To study the effects of radar radiation on sperm quality.

Methods: A total of 348 infertile seamen were divided into 4 experimental groups according to their different lengths of exposure to radar radiation: Group 1 (n = 128) exposed for 12-36 months, Group 2 (n = 58) 37-72 m, Group 3 (n = 47) 73-108 m, Group 4 (n = 19) 109 m or more and Group 5 (n = 96) 48 m or more but free from the exposure for 6 months by then. Another 35 non-marine normal males were recruited as Control Group 1, and the first four experimental groups (n = 252) were taken as Control Group 2.

[The relationship between sputum eosinophils and responses to treatment of inhaled glucocorticoids in patients with persistent asthma].

Objective: To evaluate the treatment responses of asthmatics with and without sputum eosinophilia to inhaled glucocorticoids, and therefore to verify whether low sputum eosinophils predict poor response to treatment with inhaled glucocorticoids.

Methods: Forty-two symptomatic asthmatic patients, who had not received glucocorticoid therapy in the 3 months preceding the study, were examined before and 1 month and 3 months after treatment with inhaled glucocorticoids. At each visit, all patients underwent spirometry, symptom scoring and sputum induction.

[A study on a therapeutic protocol to improve the control of persistent asthma by monitoring sputum eosinophil counts].

Objective: To evaluate the clinical applicability of a therapeutic protocol aiming to improve the control of asthma by reducing the eosinophil (EOS) counts in induced sputum.

Methods: A prospective, randomized and controlled study was conducted from February 2005 to February 2006. Forty-one patients with persistent asthma in the outpatient clinic were enrolled and randomly allocated to management groups either by minimization of the induced sputum EOS (Group A, n = 20) or by standard clinical guidelines (Group B, n = 21).

[Relationship between the endocervical mycoplasma infection and spontaneous abortion due to early embryonic death].

Objective: To study the relationship between endocervical mycoplasma infection and the spontaneous abortion due to the early embryonic death and the drug sensitivity to mycoplasma.

Methods: Endocervical swabs were taken from fifty normal pregnant women (normal group) and fifty-eight women with spontaneous abortion due to embryonic death. The swabs were used for ureaplasma urealyticum (UU) and mycoplasma hominis (MH) Cultivation respectively.