Effects of Modification on Properties of Wood Flour/PBAT Biocomposites.

Wood flour (WF)-reinforced poly (butylene adipate-co-terephthalate) (PBAT) composites were successfully fabricated by injection-molding process after being mixed using an extruder. The effects of fiber modifications, including mercerization, acetylation, as well as coupling agent treatment on the properties of WF/PBAT composites, were studied. The results indicated that all the modifications increased the mechanical properties (e.

Evolution of high-order laser array locking in high peak power fiber lasers.

Achieving stable output and control of higher-order laser arrays has long been a challenge in the development of a passively Q-switched fiber laser. In this Letter, we reported a notable peak power of 14.9 kW alongside an average output power of 0.

Traditional Chinese Medicine for Alzheimer's Disease: A Systematic Review and Meta-Analysis.

The treatment of Alzheimer's Disease (AD) remains a challenge for modern medicine due to its complex pathogenesis. Traditional Chinese Medicine (TCM) has demonstrated significant success in the prevention and treatment of variable medical conditions. For AD pharmacological management, TCM could provide promising approaches.

Ion Substitution-Induced Distorted MOF Lattice with Deviated Energy and Dielectric Properties for Quasi-Solid-State Ion Conductor.

Solid-state electrolytes are currently receiving increasing interest due to their high mechanical strength and chemical stability for safe battery construction. However, their poor ion conduction and unclear conduction mechanism need further improvement and exploration. This study focuses on a hybrid solid-state electrolyte containing MOF-based scaffolds, using metal salts as the conductor.

A new blood draw method in mice.

Background: In vivo experiments using mice play a crucial role in advancing biological and translational research due to the similarities between their biological pathways and those of humans. In this study, we utilized silicone vascular perfusion to map the venous distribution in the lower lips of mice and explored the potential for a new blood collection site in mice.

Methods: Silicone perfusion was performed in this study, revealing the venous distribution in the lower lip of mice.

Survival outcomes between haploidentical stem cell transplantation and chemotherapy for blastic plasmacytoid dendritic cell neoplasm.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive and rare hematological malignancy with poor clinical outcomes. Stem cell transplantation helps to achieve long-term survival in adults. However, the benefit of haploidentical stem cell transplantation (HID-SCT) versus chemotherapy is unclear with BPDCN.

Evolution of static fracture mechanics and energy dissipation characteristics of composites based on different interface angles.

This study aims to investigate the mechanical properties and energy characteristics of coal-rock combinations during uniaxial compression, specifically focusing on variations in interface inclination angles. Each of the stress-strain curves of the CRC (Coal-Rock-Like Material Combination) with varying interface inclination angles were obtained using the DYD-10 universal testing machine and a high-definition camera system. Subsequently, the energy of the CRC was calculated using a specific formula.

Macrofocal multiple myeloma in the era of novel agents in China.

Background: Macrofocal multiple myeloma (MFMM) is characterized by clonal plasma cells comprising less than 20% of the bone marrow, multiple lytic bone lesions, and the absence of anemia, renal insufficiency, and hypercalcemia. This subtype of multiple myeloma (MM) has a relatively low incidence. Prognostic staging and cytogenetic guidance for MFMM are often insufficient due to the low tumor burden in the bone marrow.

Pd catalysts doped with B/C atoms in the subsurface: the positive effect of interstitial atoms in regulating the selectivity of acetylene catalytic hydrogenation.

At present, the modification of palladium (Pd) catalysts is an important topic due to its potential to enhance catalytic performance and reduce catalyst costs. In this work, boron (B) and carbon (C) are interstitially doped into the subsurface of Pd to construct PdB and PdC catalysts. The adsorption properties of acetylene and ethylene, the mechanism of acetylene hydrogenation, and ethylene selectivity are studied based on density functional theory (DFT) calculations.

Overexpressed CD73 attenuates GSDMD-mediated astrocyte pyroptosis induced by cerebral ischemia-reperfusion injury through the A2B/NF-κB pathway.

Ischemic stroke, resulting from the blockage or narrowing of cerebral vessels, causes brain tissue damage due to ischemia and hypoxia. Although reperfusion therapy is essential to restore blood flow, it may also result in reperfusion injury, causing secondary damage through mechanisms like oxidative stress, inflammation, and excitotoxicity. These effects significantly impact astrocytes, neurons, and endothelial cells, aggravating brain injury and disrupting the blood-brain barrier.

Manipulation of Surface Spin Configurations for Enhanced Performance in Oxygen Evolution Reactions.

studies of the relationship between surface spin configurations and spin-related electrocatalytic reactions are crucial for understanding how magnetic catalysts enhance oxygen evolution reaction (OER) performance under magnetic fields. In this work, 2D FeSe nanosheets with rich surface spin configurations are synthesized via chemical vapor deposition. magnetic force microscopy and Raman spectroscopy reveal that a 200 mT magnetic field eliminates spin-disordered domain walls, forming a spin-ordered single-domain structure, which lowers the OER energy barrier, as confirmed by theoretical calculations.

The burden of multiple myeloma in China: Trends from 1990 to 2021 and forecasts for 2050.

This study updates the disease burden of multiple myeloma (MM) in thirty-three provincial administrative units in China from 1990 to 2021 and forecast the disease burden for 2050. Data from the 2021 Global Burden of Disease (GBD) database was used for analysis. In 2021, there were an estimated 17,250 new MM cases and 12,984 deaths in China.

Tandem Versus Single Autologous Stem Cell Transplantation for High-Risk Multiple Myeloma in the Era of Novel Agents: A Real-World Study of China.

Background: This study compares the efficacy and safety of single autologous stem cell transplantation (ASCT) versus tandem ASCT for multiple myeloma (MM) patients in the era of novel agents.

Methods: A total of 112 high-risk MM patients were included (single ASCT, (n = 57) or tandem ASCT(n = 55) in this retrospective multicenter study. Responses and outcomes were evaluated.

Single-Cell Multiomics Reveals TCR Clonotype-Specific Phenotype and Stemness Heterogeneity of T-ALL Cells.

T-cell acute lymphoblastic leukaemia (T-ALL) is a heterogeneous malignant disease with high relapse and mortality rates. To characterise the multiomics features of T-ALL, we conducted integrative analyses using single-cell RNA, TCR and chromatin accessibility sequencing on pre- and post-treatment peripheral blood and bone marrow samples of the same patients. We found that there is transcriptional rewiring of gene regulatory networks in T-ALL cells.

Clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease.

Background: Vertebral augmentation is the preferred treatment for Kümmell disease (KD), but there exists a risk of cement displacement resulting in severe back pain and exacerbation of kyphosis. The study aimed to investigate the efficacy and safety of a novel hollow pedicle screw combined with kyphoplasty (HPS-KP) for treating KD, effectively preventing postoperative bone cement displacement.

Methods: The prospective study included 50 KD patients with no neurological deficit detected during clinical and radiological evaluation who underwent HPS-KP ( = 25) and PKP ( = 25) surgeries.

Two-dimensional Cu-phenylalanine nanoflakes for efficient and robust CO electroreduction to C products.

The electrocatalytic reduction of CO to multicarbon (C) products is of great importance but still faces challenges. The moderate oxidation state of Cu (Cu) plays a critical role in promoting the C-C coupling, thereby enhancing the Faraday efficiency (FE) for C products. However, Cu active species are unstable during the reaction.

Safety and efficacy of adjuvant FOLFOX/FOLFIRI with versus without hepatic arterial infusion of floxuridine in patients following colorectal cancer liver metastasectomy (HARVEST trial): A randomized controlled trial.

Background: Hepatic artery infusion (HAI) chemotherapy, particularly with floxuridine (FUDR), has previously shown effectiveness in improving recurrence-free survival (RFS) in colorectal cancer (CRC) patients with colorectal liver metastases (CRLM). Nonetheless, its adjuvant use alongside modern systemic chemotherapy remains unevaluated.

Patients And Methods: The HARVEST trial is an open-label, randomized, controlled study conducted from May 2018 to August 2021.

Early dFLC response by C1D7 predicts complete hematologic response in systemic AL amyloidosis.

Daratumumab and bortezomib, the first-line drugs for AL amyloidosis, typically yield a complete hematologic response (CHR) rate of nearly 60% when used in combinations. An early achievement of CHR is crucial in amyloidosis. We retrospectively evaluated the relationship between dFLC (the difference between free light chain) reduction by Day 7 in Cycle 1 (C1D7) and CHR, organ response, and survival in 48 newly diagnosed AL amyloidosis patients receiving daratumumab, bortezomib, and dexamethasone.

FDM 3D Printing and Properties of WF/PBAT/PLA Composites.

Fused deposition molding (FDM) is a commonly used 3D printing method, and polylactic acid (PLA) has become one of the most important raw materials for this technology due to its excellent warping resistance. However, its mechanical properties are insufficient. Polybutylene adipate terephthalate (PBAT) is characterized by high toughness and low rigidity, which can complement the performance of PLA.

Enhanced performance of flexible BiFeO ferroelectric memory with Mica substrate via SrTiO buffer layer.

BiFeO (BFO) application in flexible wearable devices is garnering interest because of its unique ferroelectric and magnetic properties. However, the integration of high-quality BFO films onto flexible substrates presents significant technical challenges. Here, we successfully fabricated high-quality BFO films on mica substrates by using pulsed laser deposition, and report the fatigue characteristics of BFO films on flexible substrates for the first time.