[Retracted] Ferruginol exhibits anticancer effects in OVCAR‑3 human ovary cancer cells by inducing apoptosis, inhibition of cancer cell migration and G2/M phase cell cycle arrest.

Following the publication of the above paper, an interested reader drew to our attention that a number of apparent anomalies existed with the data presented in a couple of the figures in the above paper. Specifically, there appeared to be strikingly similar and duplicated patternings of cells within the cellular images featured in Figs. 3 and 4, which showed apoptotic induction as evaluated by fluorescence microscopy and TEM evaluation of ferruginol‑induced apoptosis in OVCAR‑3 human ovary cancer cells, respectively.

L-Tetrahydropalmatine enhances the sensitivity of human ovarian cancer cells to cisplatin via microRNA-93/PTEN/Akt cascade.

Purpose: Το evaluate the effect of L-Tetrahydropalmatine (L-THP) on the sensitivity of a cisplatin resistant ovarian cancer (OC) cell line. As miR-93 is reported to be overexpressed in OC and cisplatin resistance, we also evaluated its pathway in OC.

Methods: The levels of miR-93 were evaluated using RT-PCR and Luciferase assay was performed to confirm the target of miR-93.

Ferruginol exhibits anticancer effects in OVCAR‑3 human ovary cancer cells by inducing apoptosis, inhibition of cancer cell migration and G2/M phase cell cycle arrest.

The primary aim of the current study was to investigate the antitumor effects of ferruginol in OVCAR‑3 human ovary cancer cells. The effects of ferruginol on cell apoptosis, cell migration and cell cycle phase distribution were also evaluated. Cell cytotoxicity induced by ferruginol was determined by an MTT assay, while fluorescence microscopy and transmission electron microscopy (TEM) were performed to investigate apoptotic effects.