Publications by authors named "Wen Da Zhou"
Article Synopsis
- - The study aimed to measure subfoveal choroidal thickness (SFCT) in highly myopic eyes and to find associated risk factors, using advanced imaging techniques.
- - Researchers analyzed data from 103 highly myopic eyes and 227 normal eyes, revealing that SFCT was significantly lower in myopic eyes, especially in certain regions of the macula.
- - The findings indicated that SFCT decreases with age, longer axial length, and the presence of posterior staphyloma, which could help inform risk management for myopic degeneration.
Background: To examine if pregnancy affects the prognosis of uveal melanoma (UM) patients undergoing plaque brachytherapy (PBT) and to assess if PBT has any subsequent impact on pregnancy outcomes.
Methods: A retrospective, single-center study was carried out at Beijing Tongren Hospital, focusing on women of childbearing age diagnosed with UM and treated with iodine-125 plaque brachytherapy. Both the outcomes of pregnancies and the health status of the fetuses were monitored.
Reduction of experimental ocular axial elongation by neuregulin-1 antibody.
Front Med (Lausanne)
October 2023
Background: Since the mechanisms underlying myopic axial elongation have remained unclear, we examined the effect of neuregulin-1 (NRG-1), an epidermal growth factor family member, on myopic axial elongation.
Methods: The guinea pigs aged two to three weeks were subjected to bilateral negative lens-induced axial elongation and received weekly intravitreal injections into their right eyes of NRG-1 antibody (doses: 5 μg, = 8; 10 μg, = 8, 20 μg, = 9) or of NRG-1 (doses: 0.05 μg, = 8; 0.
This study aimed to examine the intraocular tolerability of the epidermal growth factor receptor antibody cetuximab, when applied intravitreally, and its effect on axial elongation. Guinea pigs aged 2-3 weeks were subjected to bilateral plano glasses and bilateral lens-induced myopization (LIM) as a single procedure for group I (n = 8) and group II (n = 8), respectively. In the animals of group III (n = 8), group IV (n = 8), and group V (n = 8), the right eyes of the animals, in addition to LIM, received four weekly intravitreal injections of cetuximab (Erbitux®) in doses of 6.
View Article and Find Full Text PDFBackground: Epidermal growth factor (EGF) and its family members have been reported to be involved in myopic axial elongation. We examined whether short hairpin RNA attenuated adeno-associated virus (shRNA-AAV)-induced knockdown of amphiregulin, an EGF family member, has an influence on axial elongation.
Methods: Three-week-old pigmented guinea pigs underwent lens-induced myopization (LIM) without additional intervention (LIM group; n = 10 animals) or additionally received into their right eyes at baseline an intravitreal injection of scramble shRNA-AAV (5 × 1010 vector genome [vg]) (LIM + Scr-shRNA group; n = 10) or of amphiregulin (AR)-shRNA-AAV (5 × 1010 vg/5 µL) (LIM + AR-shRNA-AAV group; n = 10), or they received an injection of AR-shRNA-AAV at baseline and three weekly amphiregulin injections (20 ng/5 µL) (LIM + AR-shRNA-AAV + AR group; n = 10).
Purpose: Studies have indicated that the observed association between vitamin D and myopia was confounded by time spent outdoors. This study aimed to elucidate this association using a national cross-sectional dataset.
Methods: Participants with 12 to 25 years who participated in non-cycloplegic vision exam from National Health and Nutrition Examination Survey (NHANES) 2001 to 2008 were included in the present study.
Purpose: Assess the beta zone parapapillary atrophy in elderly Chinese.
Patients And Methods: The Beijing Eye Study 2011 is a population-based cross-sectional study, which includes 3468 patients with the average age of 64.5 ± 9.
Development and validation of medical record-based logistic regression and machine learning models to diagnose diabetic retinopathy.
Graefes Arch Clin Exp Ophthalmol
March 2023
Purposes: Many factors were reported to be associated with diabetic retinopathy (DR); however, their contributions remained unclear. We aimed to evaluate the prognostic and diagnostic accuracy of logistic regression and three machine learning models based on various medical records.
Methods: This was a cross-sectional study.
Objectives: Major ocular diseases share common risk factors and pathogeneses with stroke. This study aimed to evaluate the relation between stroke and ocular diseases including visual impairment (VI).
Methods: The cross-sectional study investigated the prevalence and associations of VI and major eye diseases with stroke among 4570 participants in the 2005-2008 National Health and Nutrition Examination Survey (NHANES).
Prevalence and associations of asteroid hyalosis: the Beijing Eye Study.
BMC Ophthalmol
September 2022
Article Synopsis
- * Out of 3,419 assessable subjects, 63 eyes from 53 individuals (0.9% prevalence) were found to have AH, with a notable association of AH occurring more frequently in older individuals, those with thicker lenses, and higher spherical equivalents.
- * Interestingly, the study concluded that AH prevalence (1.6% for subjects) was not linked to diabetes or other systemic health indicators, emphasizing age and specific ocular traits as key factors.
Background: To examine an effect of intravitreally applied antibodies against epidermal growth factor family members, namely epiregulin, epigen and betacellulin, on ocular axial elongation.
Methods: The experimental study included 30 guinea pigs (age:3-4 weeks) which underwent bilateral lens-induced myopization and received three intraocular injections of 20 µg of epiregulin antibody, epigen antibody and betacellulin antibody in weekly intervals into their right eyes, and of phosphate-buffered saline into their left eyes. Seven days after the last injection, the animals were sacrificed.
For uveal melanoma (UM) patients, it is significant to establish diagnosis and prognosis evaluation systems through imaging techniques. However, imaging examinations are short of quantitative biomarkers and it is difficult to finish early diagnosis of UM. In order to discover new molecular biomarkers for the diagnosis and prognostic evaluation of UM, six circulating miRNAs (mir-132-3p, mir-21-5p, mir-34a-5p, mir-126-3p, mir-199a-3p, mir-214-3p) were chosen as candidates for independent validation.
View Article and Find Full Text PDFPrediction of the Fundus Tessellation Severity With Machine Learning Methods.
Front Med (Lausanne)
March 2022
Article Synopsis
- The study aimed to use machine learning methods to predict the severity of fundus tessellation (FT) from a large population sample of 3,468 individuals.
- Five machine learning techniques were applied, with ordinal forest providing the best in-sample performance (81.28% precision), while ordinal logistic regression excelled in out-of-sample predictions (77.12% precision).
- The effective threshold ranges identified can assist clinicians in screening fundus diseases and assessing FT severity.
Article Synopsis
- Cause-specific prevalence data of vision loss and blindness is crucial for shaping public health policies and guiding research priorities.
- In 2019, uncorrected refractory error and cataracts were the leading causes of vision impairment, with women experiencing higher rates of certain conditions compared to men.
- Retinopathy of prematurity (ROP) is a significant contributor to neonatal vision loss, particularly in Africa and East Asia, and improving government health spending may help reduce its impact.
Purpose: To study thickness of RPE-BM complex in adult Chinese subjects and its correlation with systemic and ocular biometric parameters.
Design: Population-based longitudinal study. Cross-sectional study.
Article Synopsis
- A study was conducted to examine how common vitreous macular traction (VMT) is among the Chinese population, specifically in Greater Beijing, with a sample of 3,468 individuals aged around 64.6 years.
- VMT was found in 2.3% of eyes and 2.4% of subjects, with the average age of those affected being 70.1 years.
- The analysis showed that older age, being female, and specific retinal thickness measurements were associated with a higher prevalence of VMT.
Background: To evaluate global burden of refraction disorders by year, age, region, gender, socioeconomic status and other national characteristics in terms of disability adjusted life years (DALYs) and prevalence from Global Burden of Disease (GBD) study 2019 and World Bank Open Data 2019.
Methods: Global, regional, and national DALY numbers, crude DALY rates, age-standardized DALY and prevalence rates of refraction disorders were acquired from the GBD study 2019. Mobile cellular subscriptions, urban population, GDP per capita, access to electricity and total fertility rate were obtained from the World Bank to explore the factors that influenced the health burden of refraction disorders.
Purpose: This study aimed to quantitative assess the fundus tessellated density (FTD) and associated factors on the basis of fundus photographs using artificial intelligence.
Methods: A detailed examination of 3468 individuals was performed. The proposed method for FTD measurements consists of image preprocessing, sample labeling, deep learning segmentation model, and FTD calculation.