Much research in optics was conducted to retrieve phase of the light field, e.g., via a reference wave (such as holography) or single-path optical diffraction.
View Article and Find Full Text PDFIntroduction: The immersive and interactive nature of panoramic video empowers learners with experiences that are infinitely close to the real environment and increases the use of imagination in learners' knowledge acquisition. Studies have shown that embedding question feedback in traditional educational videos can effectively improve learning. However, little research has been conducted on embedding question feedback in panoramic videos to explore what types of question feedback effectively improve the dimensions of learners' learning engagement and yield better learning experiences and learning effects.
View Article and Find Full Text PDFOsteoarthritis (OA) is a common degenerative joint disease that progressively destroys articular cartilage, leading to increased joint friction and severe pain. Therefore, OA can be treated by restoring the lubricating properties of cartilage. In this study, recent advances in lubricants for the treatment of OA are reviewed for both single-function and multifunctional lubricants.
View Article and Find Full Text PDFIn diabetic wounds, the presence of hyperglycemia is often accompanied by a persistent inflammatory response, oxidative stress damage, impaired angiogenesis and bacterial infections around the wound, resulting in impaired proliferation of dermal and epidermal cells and impaired skin regeneration in diabetic wounds. To solve the above problems, this study designed a near-infrared (NIR) light-responsive multifunctional poloxamer hydrogel (EGF/PDA-MXene Gel). The Gel is composed of two-dimensional nanomaterials (2D NMs) MXene as the core, modified by polymer, further loaded with epidermal growth factor (EGF), and has antibacterial, antioxidant, photothermal properties.
View Article and Find Full Text PDFParathyroid ultrasound is widely used in clinical practice and plays a crucial role in the diagnosis and treatment of parathyroid diseases. Nevertheless, ultrasound physicians frequently encounter a number of challenges and doubts in their professional practice. For this reason, Superficial Organs and Peripheral Vessels Committee of Chinese Association of Ultrasound in Medicine and Engineering has formulated the expert consensus on certain common clinical problems of parathyroid ultrasound based on the current research progress and clinical experience, in order to guide the clinical practice.
View Article and Find Full Text PDFBackground: The early diagnosis and management of lung adenocarcinoma co-existing with tuberculosis (LAC-TB) presents significant challenges in clinical settings. This is compounded by a paucity of robust clinical evidence elucidating the interactions between these two conditions.
Methods: This study included 14 patients diagnosed with LAC-TB, with an equal distribution among those with pulmonary tuberculosis (TB) and those with peripheral lymph node TB.
Objectives: Global countries often apply containment policies (CPs) to combat infectious disease surges. Whether countries with longer cumulative duration of CPs are associated with slower long-term epidemic progression necessitates a thorough evaluation.
Methods: We collected CP and COVID-19 data of 185 territories during 2020-2022, with a total of 23 CPs.
Background: Bisphenol A (BPA) exposure may lead to neurodevelopmental disorders and problems (NDPs) in children under 12 years old. In recent years, the number of relevant studies has increased, but the evidence is inconsistent. Therefore, we conducted a comprehensive systematic review and meta-analysis to determine the association between BPA exposure and NDPs and potential gender differences.
View Article and Find Full Text PDFPurpose: To assess the relationship between clinical prognosis and changes of skeletal muscle mass for unresectable hepatocellular carcinoma (uHCC) patients who received transarterial chemoembolization (TACE) with molecular-targeted agents and immune checkpoint inhibitors (TACE-MTAs-ICIs).
Methods: From June 2019 to June 2023, a total of 92 uHCC patients who received TACE-MTAs-ICIs therapy were included. Skeletal muscle mass was assessed before and 6 months after treatment.
Engineering nanomaterials at single-atomic sites could enable unprecedented catalytic properties for broad applications, yet it remains challenging to do so on the surface of multimetallic nanocrystals. Herein, we present the multifactorial engineering (size, shape, phase, and composition) of the fully ordered PtBi nanoplates at atomic level, achieving a unique catalyst surface where the face-centered cubic (fcc) Pt edges are modified by the isolated Pd atoms and BiO adatoms. This Pd/Pt-BiO electrocatalyst exhibits an ultrahigh mass activity of 16.
View Article and Find Full Text PDFGallbladder cancer (GBC) is the most common malignant tumor of the biliary tract and is often prone to early distant metastasis. However, the mechanisms underlying GBC's invasive metastasis remain unclear. This study identified that F-box only protein 33 (FBXO33) expression is significantly elevated in GBC and is negatively associated with patient prognosis.
View Article and Find Full Text PDFMacroscopic interactions of liquid iron and solid oxides, such as alumina, calcia, magnesia, silica, and zirconia, manifest the behavior and efficiency of high-temperature metallurgical processes. The oxides serve dual roles, both as components of refractory materials in submerged entry nozzles and also as significant constituents of nonmetallic inclusions in the melt. It is therefore crucial to understand the physicochemical interplay between the liquid and the oxides in order to address the nozzle clogging challenges and thereby optimize cast iron and steel production.
View Article and Find Full Text PDFInt Immunopharmacol
April 2025
Endometrial cancer (EC) is a common malignant disease in women, originating from the endometrial tissue. Over the past few decades, the global incidence rate of EC has gradually increased, and the affected population has become progressively younger. Traditional treatment methods, such as surgery and adjuvant therapy, have considerable toxic side effects.
View Article and Find Full Text PDFThe modern livestock industry faces significant challenges due to the extension of production cycles and a growing shortage of feed resources. Low-protein (LP) diets offer potential environmental advantages whereas damage intestinal integrity and increase pro-inflammatory cytokines. Bile acids (BAs), metabolic products of cholesterol in the liver, possess strong antioxidative and immune properties.
View Article and Find Full Text PDFCurr Issues Mol Biol
February 2025
pv. (Psa) is responsible for causing kiwifruit canker disease. The detection of Psa is commonly carried out using normal PCR and culture-based isolation.
View Article and Find Full Text PDFFour previously undescribed steroids, named sarmutogenin diginoside, sarmutogenin oleandroside, 16-hydroxy-17βH sarmutogenin digitaloside and 12-dehydroxy sarmutogenin diginoside (1-4), along with eight known ones (5-12) were isolated from the stems and leaves of Strophanthus divaricatus. The chemical structures of the new compounds including their absolute configurations, were characterized by extensive spectroscopic methods, electronic circular dichroism (ECD), X-ray diffraction, as well as comparison with literature data. Most of the isolated compounds demonstrated superior antiproliferative activities against A549 non-small cell lung cancer (NSCLC) cells compared to cisplatin, a first-line treatment regimen for NSCLC.
View Article and Find Full Text PDFTransition metal doping and nanostructure engineering are effective strategies to overcome the limitations of photocatalysts in peroxomonosulfate (PMS) activation. In this study, Cu-doped MoS with a hierarchical microspheric architecture was synthesized via a one-step hydrothermal method and employed for tetracycline (TC) degradation through PMS activation. Under visible light irradiation, the Cu-MoS catalyst achieved an 86.
View Article and Find Full Text PDFCTP synthase (CTPS) is a rate-limiting enzyme that controls CTP synthesis and can polymerize to form a filamentous structure called cytoophidia. The presence of cytoophidia affects the enzymatic activity of CTPS. However, whether CTPS can form cytoophidia in C2C12 cells and whether it affects the proliferation of skeletal muscle satellite cells needs to be further studied.
View Article and Find Full Text PDFBone Morphogenetic Protein-2 (BMP-2) is a key growth factor for inducing osteogenic differentiation and promoting bone remodeling. However, the exogenous application of delivery systems for BMP-2 has been hampered by various postoperative complications, poor stability and high price. Hence, in situ enrichment of endogenous BMP-2 is promising.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
Engineering Pt-based multimetallic nanoalloys could boost electrocatalysis in broad applications, yet it remains challenging in terms of its rational design and synthesis of a highly diluted alloy with unprecedented Pt atomic utilization. Herein, atomically dispersed Pt anchored on the surface of novel RhBi intermetallic nanoplates (RhBi-Pt) is achieved by atomic replacement, which transforms into a tensile-strained and highly diluted RhPt alloy (RhBi@RhPt) via electrochemical dealloying. Due to the diluted Pt atoms and tensile-strained Rh shell, the RhBi@RhPt electrocatalyst exhibits a remarkably enhanced peak mass activity of 32459.
View Article and Find Full Text PDFBackground: Recurrent pulmonary vein stenosis (PVS) following surgical repair of total anomalous pulmonary venous connection is associated with poor prognosis. Preclinical studies have shown that use of an angiotensin receptor blocker can attenuate intimal hyperplasia; notwithstanding, its clinical utility is of uncertain benefit.
Methods: This single-center study included patients undergoing total anomalous pulmonary venous connection repair in 2020 to 2021.
Heavy metal pollution in groundwater is a serious threat to ecological security and human health. High arsenic, iron, and manganese groundwaters are widely distributed in the Poyang Lake Plain in the middle reaches of the Yangtze River. Urbanization and anthropogenic activities have further aggravated heavy metal pollution in groundwater.
View Article and Find Full Text PDFFibrosis is a common and integral pathological feature in various chronic diseases, capable of affecting any tissue or organ. Fibrosis within deep fascia is implicated in many myofascial disorders, including gluteal muscle contracture (GMC), Dupuytren's disease, plantar fasciitis, iliotibial band syndrome, and chronic muscle pain. Despite its clinical significance, deep fascia fibrosis remains considerably under-researched compared to other fibrotic conditions.
View Article and Find Full Text PDFPurpose: The current therapeutic strategies for neuropathic pain have limited efficacy. The activation of macrophages and pro-inflammatory responses following peripheral nerve injury can effectively prevent the progression of neuropathic pain. Macrophage polarization to the M2 or M1 (respectively anti- and pro- inflammatory) phenotypes frequently occurs during neuroinflammation.
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