Two-Qubit Operations for Finite-Energy Gottesman-Kitaev-Preskill Encodings.

We present techniques for performing two-qubit gates on Gottesman-Kitaev-Preskill (GKP) codes with finite energy, and find that operations designed for ideal infinite-energy codes create undesired entanglement when applied to physically realistic states. We demonstrate that this can be mitigated using recently developed local error-correction protocols, and evaluate the resulting performance. We also propose energy-conserving finite-energy gate implementations which largely avoid the need for further correction.

A quantum-network register assembled with optical tweezers in an optical cavity.

Quantum computation and quantum communication are expected to provide users with capabilities inaccessible by classical physics. However, scalability to larger systems with many qubits is challenging. One solution is to develop a quantum network consisting of small-scale quantum registers containing computation qubits that are reversibly interfaced to communication qubits.

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity.

Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intravital two-photon imaging, we find that in contrast to most plasma cells (PCs) in the bone marrow (BM), LLPCs are uniquely sessile and organized into clusters that are dependent on APRIL, an important survival factor.

Telemedicine for Ketogenic Dietary Treatment in Refractory Epilepsy and Inherited Metabolic Disease: State of Play and Future Perspectives.

Ketogenic dietary therapies (KDT) are diets that induce a metabolic condition comparable to fasting. All types of KDT comprise a reduction in carbohydrates whilst dietary fat is increased up to 90% of daily energy expenditure. The amount of protein is normal or slightly increased.

Etiology-independent activation of the LTβ-LTβR-RELB axis drives aggressiveness and predicts poor prognosis in HCC.

Background And Aims: HCC is the most common primary liver tumor, with an increasing incidence worldwide. HCC is a heterogeneous malignancy and usually develops in a chronically injured liver. The NF-κB signaling network consists of a canonical and a noncanonical branch.

Integrated Telehealth Infrastructure for Ambulatory Stroke Pathway Tyrol.

Background: The Integrated Treatment Pathway Stroke Tyrol was introduced for the care of people after an acute stroke event and includes four phases: acute prehospital care, inpatient treatment, inpatient rehabilitation and ambulatory, outpatient rehabilitation. For the 4th phase, the ambulatory rehabilitation of patients after discharge, the ICT platform "StrokeNet Tyrol" was established.

Methods: Requirements and processes along the pathway and between the interdisciplinary team were taken into account for implementation based on a modular software architecture.

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity.

Durable serological memory following vaccination is critically dependent on the production and survival of long-lived plasma cells (LLPCs). Yet, the factors that control LLPC specification and survival remain poorly resolved. Using intra-vital two-photon imaging, we find that in contrast to most plasma cells in the bone marrow, LLPCs are uniquely sessile and organized into clusters that are dependent on April, an important survival factor.

Specific Targeting of Antiapoptotic Bcl-2 Proteins as a Radiosensitizing Approach in Solid Tumors.

Avoidance of therapy-induced apoptosis is a hallmark of acquired resistance towards radiotherapy. Thus, breaking resistance still challenges modern cancer therapy. The Bcl-2 protein family is known for its regulatory role in apoptosis signaling, making Bcl-2, Mcl-1 and Bcl-x promising targets.

New Constraint on the Local Relic Neutrino Background Overdensity with the First KATRIN Data Runs.

We report on the direct search for cosmic relic neutrinos using data acquired during the first two science campaigns of the KATRIN experiment in 2019. Beta-decay electrons from a high-purity molecular tritium gas source are analyzed by a high-resolution MAC-E filter around the end point at 18.57 keV.

µRA-A New Compact Easy-to-Use Raman System for All Hydrogen Isotopologues.

We have developed a new compact and cost-efficient Laser-Raman system for the simultaneous measurement of all six hydrogen isotopologues. The focus of this research was set on producing a tool that can be implemented in virtually any existing setup providing in situ process control and analytics. The "micro Raman (µRA)" system is completely fiber-coupled for an easy setup consisting of (i) a spectrometer/CCD unit, (ii) a 532 nm laser, and (iii) a commercial Raman head coupled with a newly developed, tritium-compatible all-metal sealed DN16CF flange/Raman window serving as the process interface.

Accurate Reference Gas Mixtures Containing Tritiated Molecules: Their Production and Raman-Based Analysis.

Highly accurate, quantitative analyses of mixtures of hydrogen isotopologues-both the stable species, H, D, and HD, and the radioactive species, T, HT, and DT-are of great importance in fields as diverse as deuterium-tritium fusion, neutrino mass measurements using tritium β-decay, or for photonuclear experiments in which hydrogen-deuterium targets are used. In this publication we describe a production, handling, and analysis facility capable of fabricating well-defined gas samples, which may contain any of the stable and radioactive hydrogen isotopologues, with sub-percent accuracy for the relative species concentrations. The production is based on precise manometric gas mixing of H, D, and T.

Feasibility and effectiveness of a multidimensional post-discharge disease management programme for heart failure patients in clinical practice: the HerzMobil Tirol programme.

Aims: It remains unclear whether transitional care management outside of a clinical trial setting provides benefits for patients with acute heart failure (AHF) after hospitalization. We evaluated the feasibility and effectiveness of a multidimensional post-discharge disease management programme using a telemedical monitoring system incorporated in a comprehensive network of heart failure nurses, resident physicians, and secondary and tertiary referral centres (HerzMobil Tirol, HMT), METHODS AND RESULTS: The non-randomized study included 508 AHF patients that were managed in HMT (n = 251) or contemporaneously in usual care (UC, n = 257) after discharge from hospital from 2016 to 2019. Groups were retrospectively matched for age and sex.

Detecting an Itinerant Optical Photon Twice without Destroying It.

Nondestructive quantum measurements are central for quantum physics applications ranging from quantum sensing to quantum computing and quantum communication. Employing the toolbox of cavity quantum electrodynamics, we here concatenate two identical nondestructive photon detectors to repeatedly detect and track a single photon propagating through a 60 m long optical fiber. By demonstrating that the combined signal-to-noise ratio of the two detectors surpasses each single one by about 2 orders of magnitude, we experimentally verify a key practical benefit of cascaded nondemolition detectors compared to conventional absorbing devices.

Quantum Teleportation between Remote Qubit Memories with Only a Single Photon as a Resource.

Quantum teleportation enables the deterministic exchange of qubits via lossy channels. While it is commonly believed that unconditional teleportation requires a preshared entangled qubit pair, here we demonstrate a protocol that is in principle unconditional and requires only a single photon as an ex-ante prepared resource. The photon successively interacts, first, with the receiver and then with the sender qubit memory.

Bound on 3+1 Active-Sterile Neutrino Mixing from the First Four-Week Science Run of KATRIN.

We report on the light sterile neutrino search from the first four-week science run of the KATRIN experiment in 2019. Beta-decay electrons from a high-purity gaseous molecular tritium source are analyzed by a high-resolution MAC-E filter down to 40 eV below the endpoint at 18.57 keV.

A quantum-logic gate between distant quantum-network modules.

The big challenge in quantum computing is to realize scalable multi-qubit systems with cross-talk-free addressability and efficient coupling of arbitrarily selected qubits. Quantum networks promise a solution by integrating smaller qubit modules to a larger computing cluster. Such a distributed architecture, however, requires the capability to execute quantum-logic gates between distant qubits.

Programming towards Improved Nutrition: Welthungerhilfe's Approach to the Prevention of Malnutrition - In All Its Forms.

Social injustice and poor policy frameworks contribute to hunger and all forms of malnutrition in a variety of ways. With its work in 38 partner countries, Welthungerhilfe (WHH) aims to make a significant contribution to achieving the Sustainable Development Goal target of eradicating hunger and all forms of malnutrition by 2030. In order to achieve this, WHH has strengthened its strategic approach: "Programming towards Improved Nutrition (PtIN)" is WHH's initiative to improve nutrition among children, women, and men of vulnerable households.

Extracranial Stereotactic Body Radiotherapy in Oligometastatic or Oligoprogressive Breast Cancer.

Oligometastatic disease (OMD) and oligoprogressive disease (OPD) describe tumor states with a limited metastasization. In contrast to other disease states, treatment of OMD or OPD has not yet become common for breast cancer. We sought to understand the outcomes and toxicities of this treatment paradigm.

Percutaneous Endoscopic Gastrostomy Tube Placement in Patients with Head and Neck Cancer Treated with Radiotherapy.

Background And Aim: The primary aim of our study was to evaluate percutaneous endoscopic gastrostomy (PEG) tube placement depending on body weight and body mass index in patients undergoing radiotherapy (RT) for head and neck cancer (HNC). A secondary aim was to evaluate the course of weight change following PEG placement.

Methods: We retrospectively reviewed the medical records of 186 patients with HNC undergoing radiotherapy (RT) or chemoradiotherapy (CRT) at our institution between January 2010 and August 2017.

Improved Upper Limit on the Neutrino Mass from a Direct Kinematic Method by KATRIN.

We report on the neutrino mass measurement result from the first four-week science run of the Karlsruhe Tritium Neutrino experiment KATRIN in spring 2019. Beta-decay electrons from a high-purity gaseous molecular tritium source are energy analyzed by a high-resolution MAC-E filter. A fit of the integrated electron spectrum over a narrow interval around the kinematic end point at 18.

Age-dependent hemato- and nephrotoxicity in patients with head and neck cancer receiving chemoradiotherapy with weekly cisplatin.

Background And Purpose: In cases of simultaneous chemoradiotherapy (CRT), early recognition of toxic side effects is important, as drug discontinuation may prevent further injury. It appears favorable to undertake further steps to investigate whether patient subgroups behave differently depending on their toxicity profile.

Methods: We retrospectively analyzed 125 consecutive patients with non-metastasized carcinoma of the head and neck who were treated with CRT (cisplatin 40 mg/m weekly) in 2013/2014.

Active-Scanned Protons and Carbon Ions in Cancer Treatment of Patients With Cardiac Implantable Electronic Devices: Experience of a Single Institution.

Ionizing radiation was shown to be able to influence the function of cardiac implantable electronic devices (CIED's) leading to malfunctions with potentially severe consequences. Those effects presumably correlate with beam energy and neutron production. Thus, particle facilities are commonly cautious to treat patients with CIED's with particles, but substantial evidence is lacking.

eHealth Service for Integrated Care and Outpatient Rehabilitation - Pilot Application of the Tyrol Stroke Pathway.

Background: Stroke is one of third most common causes of death and the main cause for permanent disabilities. The Tyrol Stroke Pathway covers, all steps from stroke onset to outpatient rehabilitation.

Objectives: The main objective of this paper is to describe how the paper-based documentation in the outpatient rehabilitation can be implemented in an eHealth service for integrated care.

Single-Photon Distillation via a Photonic Parity Measurement Using Cavity QED.

Single photons with tailored temporal profiles are a vital resource for future quantum networks. Here we distill them out of custom-shaped laser pulses that reflect from a single atom strongly coupled to an optical resonator. A subsequent measurement on the atom is employed to herald a successful distillation.