Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition.

Corticosteroid-mediated stress responses require the activation of complex brain circuits involving mitochondrial activity, but the underlying cellular and molecular mechanisms are scantly known. The endocannabinoid system is implicated in stress coping, and it can directly regulate brain mitochondrial functions via type 1 cannabinoid (CB) receptors associated with mitochondrial membranes (mtCB). In this study, we show that the impairing effect of corticosterone in the novel object recognition (NOR) task in mice requires mtCB receptors and the regulation of mitochondrial calcium levels in neurons.

Gambling involvement among Native Americans, Blacks, and Whites in the United States.

Background And Objectives: This paper examines risk factors of gambling and problem gambling among racial subgroups in the U.S. population, namely Native Americans and blacks, for whom research data are lacking.

Predictors of Problem Gambling in the U.S.

In this article we examine data from a national U.S. adult survey of gambling to determine correlates of problem gambling and discuss them in light of theories of the etiology of problem gambling.

The Relationship Between Distance from Gambling Venues and Gambling Participation and Problem Gambling Among U.S. Adults.

In this article we examine the relationship between extent of gambling for U.S. adults and the distance from their residence to the nearest casino or track.

Reliability, Validity, and Classification Accuracy of the DSM-5 Diagnostic Criteria for Gambling Disorder and Comparison to DSM-IV.

The DSM-5 was published in 2013 and it included two substantive revisions for gambling disorder (GD). These changes are the reduction in the threshold from five to four criteria and elimination of the illegal activities criterion. The purpose of this study was to twofold.

The Relationship Between the Number of Types of Legal Gambling and the Rates of Gambling Behaviors and Problems Across U.S. States.

In this article, we examine the relationship between the total number of types of gambling that are legal in a state and the gambling involvement of state residents. Of particular interest is whether more types of legal gambling are associated with higher rates of problem gambling. Telephone surveys of U.

Gambling and Substance Use: Co-occurrence among Adults in a Recent General Population Study in the United States.

This study is an up-to-date examination of gambling behaviors as well as gambling problems and their relationships to substance use and abuse. Further, the co-occurrence between problem gambling and substance abuse is studied using a large-scale, representative sample of adults aged 18 years and older in the United States. This random-digit-dial national survey was carried out in 2011-2013 with completed interviews from 2,963 respondents.

Sociocultural Influences on Gambling and Alcohol Use Among Native Americans in the United States.

Gambling opportunities on and near Native American lands have increased in recent decades; yet there is a lack of research examining the patterns of problem gambling and alcohol abuse among Native Americans in the US. Traditional Native American cultural identity may be a protective factor for problem gambling and alcohol abuse among Native Americans. Telephone interviews were conducted with 415 Native American adults aged 18 years and older across the US.

Gambling and Problem Gambling in the United States: Changes Between 1999 and 2013.

Telephone surveys of US adults were conducted in 1999-2000 and again in 2011-2013. The same questions and methods were used so as to make the surveys comparable. There was a reduction in percentage of past-year gambling and in frequency of gambling.

The link between early onset drinking and early onset alcohol-impaired driving in young males.

Background: Young drivers represent a disproportionate number of the individuals involved in alcohol-impaired driving. Although there is a known association between drinking and alcohol-impaired driving in young drivers, the link between early onset drinking and early onset alcohol-impaired driving has not been explored.

Objectives: The present study aimed to assess this link along with potentially confounding factors.

D3, the new diffractometer for the macromolecular crystallography beamlines of the Swiss Light Source.

A new diffractometer for microcrystallography has been developed for the three macromolecular crystallography beamlines of the Swiss Light Source. Building upon and critically extending previous developments realised for the high-resolution endstations of the two undulator beamlines X06SA and X10SA, as well as the super-bend dipole beamline X06DA, the new diffractometer was designed to the following core design goals. (i) Redesign of the goniometer to a sub-micrometer peak-to-peak cylinder of confusion for the horizontal single axis.

Computerized adaptive assessment of personality disorder: introducing the CAT-PD project.

Assessment of personality disorders (PD) has been hindered by reliance on the problematic categorical model embodied in the most recent Diagnostic and Statistical Model of Mental Disorders (DSM), lack of consensus among alternative dimensional models, and inefficient measurement methods. This article describes the rationale for and early results from a multiyear study funded by the National Institute of Mental Health that was designed to develop an integrative and comprehensive model and efficient measure of PD trait dimensions. To accomplish these goals, we are in the midst of a 5-phase project to develop and validate the model and measure.

The influence of parental and peer drinking behaviors on underage drinking and driving by young men.

Background: Studies have consistently found that parental and peer drinking behaviors significantly influence adolescent drinking behavior and that adolescent drinking has a significant effect on their drinking-and-driving behavior. Building upon these studies, the present article assesses whether parental and peer drinking behaviors have direct and indirect effects on adolescent drinking and driving as well as whether they moderate the effect of adolescent drinking on their drinking-and-driving behavior.

Methods: The assessment is conducted using data collected from the Buffalo Longitudinal Survey of Young Men (BLSYM) with Ordinary Least Squares (OLS) regression analyses.

Early onset of delinquency and the trajectory of alcohol-impaired driving among young males.

Building upon the literature in developmental and life-course criminology, the present study assesses the possible association of age onset of delinquency with the trajectory of alcohol-impaired driving using data collected from the three waves of the Buffalo Longitudinal Survey of Young Men (BLSYM). It is argued that as a unique form of delinquency, alcohol-impaired driving among adolescents may be better understood in a broad context of adolescent delinquency involvement. The study adopts the general approach for the analysis of early onset of delinquency and criminal careers in developmental and life-course criminology and hypothesizes that early onset of delinquency is associated with a higher growth of alcohol-impaired driving over time among adolescents when age onsets of alcohol-impaired driving, drinking, and drug use are controlled.

Tobacco use, heavy use, and dependence among adolescents and young adults in the United States.

Tobacco involvement among US youth was investigated in a national survey conducted in 2005-2007 of 2,274 respondents aged 14-21, including those not in school. Logistic regressions predicted tobacco involvement. Males had higher rates of tobacco use than females, but males and females had equal rates of heavy use and dependence.

The co-occurrence of gambling with substance use and conduct disorder among youth in the United States.

The co-occurrence of gambling with substance use and conduct disorder was examined in a representative U.S. household sample of 2,274 youth 14-21 years old.

Gambling on the lottery: sociodemographic correlates across the lifespan.

Two representative U.S. telephone surveys of gambling were conducted-an adult survey of adults aged 18 years and older (n = 2,631) and a youth survey of young people aged 14-21 years old (n = 2,274).

Delinquency and alcohol-impaired driving among young males: A longitudinal study.

The present study assessed how the trajectory of delinquency affects the growth curve of alcohol-impaired driving using three-waves of data collected from the Buffalo Longitudinal Survey of Young Men (BLSYM). Using the structural equation modeling method, latent growth modeling was utilized to assess four age cohorts of sixteen, seventeen, eighteen, and nineteen years of age at the first wave. The data indicated that the growth rate of delinquency significantly and positively affects the growth rate of alcohol-impaired driving for the respondents who were sixteen at the first wave.

Gambling and problem gambling across the lifespan.

Two national U.S. telephone surveys of gambling were conducted, an adult survey (age 18 and over, N = 2,631) in 1999-2000 and a youth (age 14-21, N = 2,274) survey in 2005-2007.

Comparisons of gambling and alcohol use among college students and noncollege young people in the United States.

Objective: Gambling and alcohol use were compared for college and noncollege young adults in the US population.

Participants: Participants were 1,000 respondents aged 18 to 21.

Methods: Data were analyzed from a representative household sample of US young people aged 14 to 21 years old.

Hyperfine spectroscopy of the 1s(5)-2p(9) transition of 39Ar.

We report on the first experimental determination of the hyperfine structure of the 1s(5)-2p(9) transition in (39)Ar. We give a detailed description of the sample preparation, spectroscopy cell cleaning, and spectroscopic setup. The resulting set of parameters consists of the hyperfine constants of the levels involved and the isotopic shift between (39)Ar and (40)Ar.