Mathematical model of COVID-19 intervention scenarios for São Paulo-Brazil.

With COVID-19 surging across the world, understanding the effectiveness of intervention strategies on transmission dynamics is of primary global health importance. Here, we develop and analyze an epidemiological compartmental model using multi-objective genetic algorithm design optimization to compare scenarios related to strategy type, the extent of social distancing, time window, and personal protection levels on the transmission dynamics of COVID-19 in São Paulo, Brazil. The results indicate that the optimal strategy for São Paulo is to reduce social distancing over time with a stepping-down reduction in the magnitude of social distancing every 80-days.

Mixed Modal Training to Help Older Adults Maintain Postural Balance.

Objective: Older adults have poorer balance compared with younger adults, but exercise may slow this age-related loss. Although the best type of exercise to optimize balance gains remains unclear, it is likely that a training regimen incorporating several different types of exercise, termed (MMT) (popularized by CrossFit), would be effective. Accordingly, this study aims to assess whether regular MMT leads to improved balance in older adults.

Age-associated differences in motor output variability and coordination during the simultaneous dorsiflexion of both feet.

Older adults are more variable than young adults on tasks that demand the simultaneous control of more than one effector, and the difference between age groups may be related to their different capacity of coordinating the force output of the involved effectors. The goal of this study was to determine whether age-associated differences in motor output variability during tasks involving the simultaneous dorsiflexion of two feet can be partially explained by differences in coordination and possibly attenuated by physical training. Ten young and 22 old adults (10 trained and 12 untrained old adults) volunteered to participate in the study.