Identification of emergencies in the telephone queue and routing to a fast track (FAST): study protocol for a prospective, two-armed cohort study.

Background: In Germany, the telephone patient service 116,117 for callers with non-life-threatening health issues is available 24/7. Based on structured initial assessment, urgency and placement of suitable medical care offer have been offered since 2020. The service has been in increasing demand for several years: Depending on time and residence, this can result in longer waiting times.

Prolonged complete response to adjuvant tepotinib in a patient with newly diagnosed disseminated glioblastoma harboring mesenchymal-epithelial transition fusion.

The prognosis of patients with glioblastoma (GBM) remains poor despite current treatments. Targeted therapy in GBM has been the subject of intense investigation but has not been successful in clinical trials. The reasons for the failure of targeted therapy in GBM are multifold and include a lack of patient selection in trials, the failure to identify driver mutations, and poor blood-brain barrier penetration of investigational drugs.

The impact of a training intervention on knowledge, confidence and attitudes of professionals in a Community Acquired Brain Injury Service about assistive technology for cognition: a before and after survey.

Assistive Technology for Cognition (ATC) can help people to compensate for cognitive impairments following Acquired Brain Injury (ABI). Examples include mainstream devices such as smartphones, watches and environmental controls, and bespoke devices such as medication devices or specific educational software. Evidence suggests that professional support is key to people successfully adopting ATC, yet low confidence amongst clinicians and perceptions about barriers are often cited as reasons for not recommending ATC in practice.

Eye did this! Sense of agency in eye movements.

This study investigates the sense of agency (SoA) for saccades with implicit and explicit agency measures. In two eye tracking experiments, participants moved their eyes towards on-screen stimuli that subsequently changed color. Participants then either reproduced the temporal interval between saccade and color-change (Experiment 1) or reported the time points of these events with an auditory Libet clock (Experiment 2) to measure temporal binding effects as implicit indices of SoA.

High-frequency measurement of concentration in an isothermal methane-air gas mixture using spontaneous Raman spectroscopy.

A high-frequency (1.5 kHz) spontaneous Raman spectroscopy measurement technique is developed and applied to measure external fluctuations generated in the local concentration of an isothermal binary gas mixture of methane and air. Raman excitation is provided by a high-frequency laser at 527 nm in dual-pulsed mode.

Identification of metabolic pathways contributing to ER breast cancer disparities using a machine-learning pipeline.

African American (AA) women in the United States have a 40% higher breast cancer mortality rate than Non-Hispanic White (NHW) women. The survival disparity is particularly striking among (estrogen receptor positive) ER breast cancer cases. The purpose of this study is to examine whether there are racial differences in metabolic pathways typically activated in patients with ER breast cancer.

Parents' perceptions and experiences of physical activity in childhood cancer survivors in Singapore: a qualitative study.

Introduction: The survival rate for childhood cancer has increased with advances in medical care. Along with this comes the growing burden of long-term side effects of cancer treatment and cancer survivorship. Childhood cancer survivors are more likely to be sedentary and have a lower quality of life.

Intentional binding: Merely a procedural confound?

Sense of agency (SoA) is the feeling of having control over one's actions and their outcomes. Previous research claimed that SoA is reflected in "intentional binding" effects, that is, the subjective compression of time between a voluntary action and an intended outcome. Conventional paradigms, however, typically lack an isolated manipulation of different degrees of agency (or intentionality), as the presence or absence of actions (along with subsequent perceptual changes) represents a potential confound variable.

Distracted to a fault: Attention, actions, and time perception.

In the last years, it has become general consensus that actions change our time perception. Performing an action to elicit a specific event seems to lead to a systematic underestimation of the interval between action and effect, a phenomenon termed temporal (or previously intentional) binding. Temporal binding has been closely associated with sense of agency, our perceived control over our actions and our environment, and because of its robust behavioral effects has indeed been widely utilized as an implicit correlate of sense of agency.

Improving the Usability of Galileo and Voyager Images of Jupiter's Moon Europa.

NASA's Voyager 1, Voyager 2, and Galileo spacecraft acquired hundreds of images of Jupiter's moon Europa. These images provide the only moderate- to high-resolution views of the moon's surface and are therefore a critical resource for scientific analysis and future mission planning. Unfortunately, uncertain knowledge of the spacecraft's position and pointing during image acquisition resulted in significant errors in the location of the images on the surface.

Social Action Effects: Representing Predicted Partner Responses in Social Interactions.

The sociomotor framework outlines a possible role of social action effects on human action control, suggesting that anticipated partner reactions are a major cue to represent, select, and initiate own body movements. Here, we review studies that elucidate the actual content of social action representations and that explore factors that can distinguish action control processes involving social and inanimate action effects. Specifically, we address two hypotheses on how the social context can influence effect-based action control: first, by providing unique social features such as body-related, anatomical codes, and second, by orienting attention towards any relevant feature dimensions of the action effects.

To follow or not to follow: Influence of valence and consensus on the sense of agency.

Advice from others influence our decisions. Irrespective of whether we follow them or not, we sometimes regret not having listened or blame the other for bad guidance. How does compliance with advice and outcome of the chosen action influence a person's sense of agency? We conducted two online experiments using explicit and implicit measures of the sense of agency.

Response modalities and the cognitive architecture underlying action control: Intra-modal trumps cross-modal action coordination.

Performing two actions at the same time usually hampers performance. Previous studies have demonstrated a strong impact of the particular effector systems on performance in multiple action control situations. However, an open question is whether performance is generally better or worse in situations in which two actions within the same effector system are coordinated (intra-modal actions: e.

Two faces of temporal binding: Action- and effect-binding are not correlated.

Research on the sense of agency has proliferated a range of explicit and implicit measures. However, the relation of different measures is poorly understood with especially mixed findings on the correlation between explicit judgments of agency and the implicit perceptual bias of temporal binding. Here, we add to the conundrum by showing that the two sub-components of temporal binding - action-binding and effect-binding, respectively - are not correlated across participants either, suggesting independent processes for both components.

To prevent means to know: Explicit but no implicit agency for prevention behavior.

Human agents draw on a variety of explicit and implicit cues to construct a sense of agency for their actions and the effects of these actions on the outside world. Associative mechanisms binding actions to their immediate effects support the evolution of agency for operant actions. However, human agents often also act to prevent a certain event from occurring.

Patterns of emergency department use in rural and metropolitan New South Wales from 2012 to 2018.

Objective: To explore the patterns of and investigate the factors associated with rises in emergency department presentations in rural and metropolitan New South Wales from 2012 to 2018.

Design: A retrospective descriptive study of de-identified data from the New South Wales Emergency Department Data Collection.

Setting: New South Wales, Australia.

Task relevance determines binding of effect features in action planning.

Action planning can be construed as the temporary binding of features of perceptual action effects. While previous research demonstrated binding for task-relevant, body-related effect features, the role of task-irrelevant or environment-related effect features in action planning is less clear. Here, we studied whether task-relevance or body-relatedness determines feature binding in action planning.

Development and implementation of a primary care clinic workflow protocol to meet opioid prescribing guidelines.

Background: Nearly 50% of opioid overdose deaths in the United States involve the use of prescription opioids. Primary care providers can help decrease the risk of opioid overdose deaths by adhering to opioid prescribing guidelines for chronic pain management.

Local Problem: Ten Washington State primary care clinics had gaps in guideline adherence and mandated electronic medical record (EMR) documentation for prescribing opioids.

Anticipation in sociomotor actions: Similar effects for in- and outgroup interactions.

In social interactions, own actions often trigger a particular response from another person. The sociomotor framework proposes that this consistent behavior of others can become incorporated into own action control. In line with this idea, recent studies have shown that own motor actions are facilitated if they are predictably being imitated rather than counterimitated by a social interaction partner.

Action-effect anticipation and temporal adaptation in social interactions.

Interacting agents may anticipate their partner's upcoming response and include it in their action plan. In turn, observing an overt response can trigger agents to adapt. But although anticipation and adaptation are known to shape action control, their interplay in social interactions remains largely unexplored.

When actions go awry: Monitoring partner errors and machine malfunctions.

Human actions often aim at triggering certain responses from social interaction partners, but these responses do not always come as expected. Here we show that unexpected partner errors trigger sustained monitoring and that this monitoring exceeds the level that is observed if participants are faced with a machine malfunction rather than an error of an interaction partner (Experiment 1). Critically, this pattern of results emerged even though both types of errors were signaled by physically identical events in an oddball task, ruling out alternative explanations in terms of differential bottom-up factors.

Something from nothing: Agency for deliberate nonactions.

Several law systems punish nonactions such as failures to render assistance, although it is unknown if people spontaneously experience a sense of authorship for the consequences of their not acting. Here we provide evidence that events caused by deliberate choices not to act can indeed give rise to a vivid sense of agency. In three experiments, participants reported a sense of agency for events following nonactions and, crucially, temporal binding between nonactions and subsequent consequences suggested a sense of agency for nonactions even at an implicit level.

Connecting action control and agency: Does action-effect binding affect temporal binding?

The sense of agency, i.e., the notion that we, as agents, are in control of our own actions and can affect our environment by acting, is an integral part of human volition.

The effects of action choice on temporal binding, agency ratings, and their correlation.

The sense of agency, i.e., the feeling of control over one's own actions and their consequences in the environment, is a crucial part of action taking.