Publications by authors named "Weizi Cheng"
Article Synopsis
- This study investigates how IL-25 affects mesenchymal stem cells' (MSCs) ability to help regenerate intestinal epithelial cells, particularly in inflammatory bowel disease (IBD) patients.
- It involved analyzing specific cell types in patients with Crohn's disease and ulcerative colitis, using techniques such as immunofluorescence staining and flow cytometry, as well as testing how MSCs treated with IL-25 influence cell growth.
- The findings indicate that IL-25R plays a role in mucosal inflammation and cell proliferation in IBD, suggesting that MSC therapy enhanced by IL-25 could be a promising new treatment approach for these conditions.
Aim: This study aimed to investigate the anti-inflammatory mechanism of IL-25 mediated mesenchymal stem cells (MSC) treatment for inflammatory bowel disease (IBD) in a DSS-induced rat colitis model.
Methods: Rats with DSS-induced colitis were divided into control and treatment groups: normal control group (rats fed with water), DSS group (rats fed with DSS solution), MSC group (DSS-treated rats injected intravenously with GFP-MSCs), IL-25-MSC group (DSS-treated rats injected intravenously with IL-25 primed GFP-MSCs), and mesalazine group (DSS-treated rats fed with mesalazine).
Results: In IL-25-MSC group, therapeutic efficacy (clinical symptoms) was better than in MSC group, but comparable to mesalazine group.