Is JAK effective in treating recurrent SAPHO syndrome? TwHF might be a good choice.

Background: Recently, JAKi has also been widely proved to be an effective alternative to conventional treatment for Synovitis acne pustulosis-hyperostosis-osteitis (SAPHO) cases, after failure of multiple drugs including those described above. But what to do when all these treatments fail? We report a case of remission from Tripterygium wilfordii Hook (TwHF) treatment.

Methods: The patient was treated with nonsteroidal anti-inflammatory drugs, oral prednisone, minocycline, bisphosphonate injection, etanercept, and tofacitinib, but the symptoms did not change significantly.

Not only phosphorus: dauciform roots can also influence aboveground biomass through root morphological traits and metal cation concentrations.

Background: Phosphorus in the soil is mostly too insoluble for plants to utilize, resulting in inhibited aboveground biomass, while can maintain their aboveground biomass through the presence of dauciform roots. However, dauciform roots lead to both morphological and physiological changes in the root system, making their primary mechanism unclear.

Methods: A greenhouse experiment was conducted on three species, in which Al-P, Ca-P, Fe-P, and K-P were employed as sole phosphorus sources.

Inhibition of SARS-CoV-2 infection in human airway epithelium with a xeno-nucleic acid aptamer.

Background: SARS-CoV-2, the agent responsible for the COVID-19 pandemic, enters cells through viral spike glycoprotein binding to the cellular receptor, angiotensin-converting enzyme 2 (ACE2). Given the lack of effective antivirals targeting SARS-CoV-2, we previously utilized systematic evolution of ligands by exponential enrichment (SELEX) and selected fluoro-arabino nucleic acid (FANA) aptamer R8-9 that was able to block the interaction between the viral receptor-binding domain and ACE2.

Methods: Here, we further assessed FANA-R8-9 as an entry inhibitor in contexts that recapitulate infection in vivo.

An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission.

SARS-CoV-2 is primarily transmitted through droplets and airborne aerosols, and in order to prevent infection and reduce viral spread vaccines should elicit protective immunity in the airways. The neonatal Fc receptor (FcRn) transfers IgG across epithelial barriers and can enhance mucosal delivery of antigens. Here we explore FcRn-mediated respiratory delivery of SARS-CoV-2 spike (S).

Inhibition of SARS-CoV-2 Infection in Human Airway Epithelium with a Xeno-Nucleic Acid Aptamer.

Background: SARS-CoV-2, the agent responsible for the COVID-19 pandemic, enters cells through viral spike glycoprotein binding to the cellular receptor, angiotensin-converting enzyme 2 (ACE2). Given the lack of effective antivirals targeting SARS-CoV-2, we previously utilized systematic evolution of ligands by exponential enrichment (SELEX) and selected fluoro-arabino nucleic acid (FANA) aptamer R8-9 that was able to block the interaction between the viral receptor-binding domain and ACE2.

Methods: Here, we further assessed FANA-R8-9 as an entry inhibitor in contexts that recapitulate infection .

Correction: Li et al. Novel Therapies for Tongue Squamous Cell Carcinoma Patients with High-Grade Tumors. 2021, , 813.

Yinghua Li was not included as an author in the original publication [...

Response of to phosphorus deficiency and drought stress.

Introduction: The drought and phosphorus deficiency have inevitably become environmental issues globally in the future. The analysis of plants functional trait variation and response strategies under the stress of phosphorus deficiency and drought is important to explore their ability to respond to potential ecological stress.

Methods: In this study, was selected as the research object, and a 14-week pot experiment was conducted in a greenhouse, with two phosphorus treatment (add 0.

Odontoblasts release exosomes to regulate the odontoblastic differentiation of dental pulp stem cells.

Background: Dental pulp stem cells (DPSCs) play a crucial role in dentin-pulp complex regeneration. Further understanding of the mechanism by which DPSCs remain in a quiescent state could contribute to improvements in the dentin-pulp complex and dentinogenesis.

Methods: TSC1 conditional knockout (DMP1-Cre+; TSC1, hereafter CKO) mice were generated to increase the activity of mechanistic target of rapamycin complex 1 (mTORC1).

Climate change mitigation potential of kitchen waste utilization in China for combined heat and power production.

Given the concerns about climate change, energy sustainability, and public health, the reuse of kitchen wastes (KW) is attracting increasing interest. In China, the municipal solid waste sorting scheme has increased the available KW. To assess the available KW and the climate change mitigation potential of KW utilization for bioenergy in China, three scenarios (base, conservative, and ambitious) were defined.

A Case of Neutrophilic Dermatoses-Sweet's Syndrome Coexisting with SAPHO Syndrome.

SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome is a rare disease characterized by osteoarticular and cutaneous manifestations. SAPHO syndrome mostly involves the skin, mainly presented as palmoplantar pustulosis and severe acne. Sweet's syndrome (SS) is a neutrophilic dermatosis of unknown cause, which may be caused by autoinflammation.

GLUE multimodal single cell data.

A commentary on "Multi-omics single-cell data integration and regulatory inference with graph-linked embedding".

Numerical simulation of laser-produced plasma expansion on a droplet surface.

In this study, a numerical model of the plasma expansion on a droplet surface based on the initial plasma method was proposed. The initial plasma was obtained through the pressure inlet boundary condition, and the effect of ambient pressure on the initial plasma and adiabatic expansion of the plasma on the droplet surface, including the effect on the velocity and temperature distribution, were investigated. The simulation results showed that the ambient pressure decreased, leading to an increase in the expansion rate and temperature, and therefore a larger plasma size was formed.

Three-body aggregation of guest molecules as a key step in methane hydrate nucleation and growth.

Gas hydrates have an important role in environmental and astrochemistry, as well as in energy materials research. Although it is widely accepted that gas accumulation is an important and necessary process during hydrate nucleation, how guest molecules aggregate remains largely unknown. Here, we have performed molecular dynamics simulations to clarify the nucleation path of methane hydrate.

An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission.

SARS-CoV-2 and its variants cause COVID-19, which is primarily transmitted through droplets and airborne aerosols. To prevent viral infection and reduce viral spread, vaccine strategies must elicit protective immunity in the airways. FcRn transfers IgG across epithelial barriers; we explore FcRn-mediated respiratory delivery of SARS-CoV-2 spike (S).

NETome: A model to Decode the Human Genome and Proteome of Neutrophil Extracellular Traps.

Neutrophils are the most abundant type of white blood cells in humans with biological roles relevant to inflammation, and fighting off infections. Neutrophil Extracellular Traps (NETs) act as enxogenous agents controlling invasion by bacteria, viruses, fungi, metabolic, and traumatic agents. Traditionally, studies have focused on elucidating molecular and cellular pathways preceding NET formation.

Microscopic Reservoir Characteristics of the Lacustrine Calcareous Shale: An Example from the Es Shale of the Paleogene Shahejie Formation in Boxing Sag, Dongying Depression.

The Es shale is taken as the main research object to understand and describe the reservoir characteristics in Boxing Sag, Dongying Depression. Through core observation, X-ray diffraction, thin section observation, field-emission scanning electron microscopy analysis, and low-pressure nitrogen gas adsorption experiment, the reservoir space of the Es shale including pore types, pore size, and pore structure characteristics was elucidated. The study shows that the shale in the Boxing Sag has the following characteristics: (1) the reservoir space in the study area is diverse, with the development of inorganic pores, organic pores, and microfractures.

Analysis of serum metabolism in premature infants before and after feeding using GC-MS and the relationship with necrotizing enterocolitis.

Preterm birth and enteral feeding are two main factors leading to necrotizing enterocolitis (NEC). The metabolomics of preterm infants before and after feeding can provide a basis for the prediction of NEC. Using the method of cross-sectional study, the mode was established with the serum samples of 19 premature infants at birth and after feeding as the control group.