The role of large reservoirs in drought and flood disaster risk mitigation: A case of the Yellow River Basin.

The acceleration of water cycle processes in the context of global warming will exacerbate the frequency and intensity of extreme events and predispose to drought and flood disasters (DFD). The Yellow River Basin (YRB) is one of the basins with significant and sensitive impacts of climate change, comprehensive assessment and prediction of its DFD risk are of great significance for ecological protection and high-quality development. This study first constructed an evaluation index system for drought disaster risk and flood disaster risk based on hazard, vulnerability, exposure and the role of large reservoirs.

The photosynthetic toxicity of nano-polystyrene to Microcystis aeruginosa is influenced by surface modification and light intensity.

It is known that nanoplastics can cause membrane damage and production of reactive oxygen species (ROS) in cyanobacteria, negatively impacting their photosynthetic reactions and growth. However, the synergistic effect of light intensity on nanoplastics' toxicity to cyanobacteria is rarely investigated. Here, we investigated the impact of nano-polystyrene particles (PS) and amino-modified nano-polystyrene particles (PS-NH) on cyanobacterium Microcystis aeruginosa cultivated under two light intensities.

UV-A radiation increases biomass yield by enhancing energy flow and carbon assimilation in the edible cyanobacterium .

Ultraviolet (UV) A radiation (315-400 nm) is the predominant component of solar UV radiation that reaches the Earth's surface. However, the underlying mechanisms of the positive effects of UV-A on photosynthetic organisms have not yet been elucidated. In this study, we investigated the effects of UV-A radiation on the growth, photosynthetic ability, and metabolome of the edible cyanobacterium .

[Retracted] MicroRNA‑139‑5p inhibits cell viability, migration and invasion and suppresses tumor growth by targeting HDGF in non‑small cell lung cancer.

[This retracts the article DOI: 10.3892/ol.2020.

Organic photodiodes with bias-switchable photomultiplication and photovoltaic modes.

The limited sensitivity of photovoltaic-type photodiodes makes it indispensable to use pre-amplifier circuits for effectively extracting electrical signals, especially when detecting dim light. Additionally, the photomultiplication photodiodes with light amplification function suffer from potential damages caused by high power consumption under strong light. In this work, by adopting the synergy strategy of thermal-induced interfacial structural traps and blocking layers, we develop a dual-mode visible-near infrared organic photodiode with bias-switchable photomultiplication and photovoltaic operating modes, exhibiting high specific detectivity (~10 Jones) and fast response speed (0.

Stabilizing Non-Fullerene Organic Photodiodes through Interface Engineering Enabled by a Tin Ion-Chelated Polymer.

The recent emergence of non-fullerene acceptors (NFAs) has energized the field of organic photodiodes (OPDs) and made major breakthroughs in their critical photoelectric characteristics. Yet, stabilizing inverted NF-OPDs remains challenging because of the intrinsic degradation induced by improper interfaces. Herein, a tin ion-chelated polyethyleneimine ethoxylated (denoted as PEIE-Sn) is proposed as a generic cathode interfacial layer (CIL) of NF-OPDs.

Efficient Semi-Artificial Photosynthesis of Ethylene by a Self-Assembled InP-Cyanobacterial Biohybrid System.

Biomanufacturing of ethylene is particularly important for modern society. Cyanobacterial cells are able to photosynthesize various valuable chemicals. A promising platform for next-generation biomanufacturing, the semiconductor-cyanobacterial hybrid systems are capable of enhancing the solar-to-chemical conversion efficiency.

Conversion of primary liver cancer after targeted therapy for liver cancer combined with AFP-targeted CAR T-cell therapy: a case report.

Primary liver cancer (PLC) that originates in the liver is a malignant tumor with the worst prognosis. Hepatocellular carcinoma (HCC) is the most common type of PLC. Most PLC cases are diagnosed at advanced stages mainly due to their insidious onset and rapid progression.

Liver Injury in Patients with COVID-19: A Retrospective Study.

The objective of this study is to explore the incidence, characteristics, risk factors, and prognosis of liver injury in patients with COVID-19. We collected clinical data of 384 cases of COVID-19 and retrospectively analyzed the incidence, characteristics, and risk factors of liver injury of the patients. In addition, we followed the patient two months after discharge.

A randomized, controlled clinical trial comparing remimazolam to propofol when combined with alfentanil for sedation during ERCP procedures.

Study Objective: In many countries, the combination of propofol and opioid is used as the preferred sedative regime during ERCP. However, the most serious risks of propofol sedation are oxygen deficiency and hypotension. Compared to midazolam, remimazolam has a faster onset and offset of hypnotic effect, as well as cardiorespiratory stability, and to achieve widespread acceptance for procedural sedation, remimazolam must replace propofol which is the most commonly used for procedural sedation.

A data set of distributed global population and water withdrawal from 1960 to 2020.

Population and water withdrawal data sets are currently faced with difficulties in collecting, processing and verifying multi-source time series, and the spatial distribution characteristics of long series are also relatively lacking. Time series is the basic guarantee for the accuracy of data sets, and the production of long series spatial distribution is a realistic requirement to expand the application scope of data sets. Through the time-consuming and laborious basic processing work, this research focuses on the population and water intake time series, and interpolates and extends them to specific land uses to ensure the accuracy of the time series and the demand of spatially distributed data sets.

miR-200a-3p- and miR-181-5p-Mediated HOXB5 Upregulation Promotes HCC Progression by Transcriptional Activation of EGFR.

Background: Hepatocellular carcinoma (HCC) remains a worldwide burden. However, the mechanisms behind the malignant biological behavior of HCC remain unclear. The homeobox (HOX) family could act as either promoters or suppressors in different kinds of malignancies.

Fabrication of pH/HO-responsive polyhedral oligomeric silsesquioxane self-assembled fluorescent vesicles for enhanced anti-tumor efficacy.

The rational design of a fluorescence imaging-guided, highly efficient multiresponsive delivery system is important for improving drug delivery efficiency. Herein, pH/HO-responsive polyhedral oligomeric silsesquioxane (POSS) molecule functionalized 4-(phenyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl)amino)benzaldehyde (OTB) copolymer (PEG-POSS-OTB) was synthesized to encapsulate doxorubicin (DOX) for precise drug delivery. The self-assembly fluorescent vesicles exhibited excellent pH/HO-responsive drug release properties under physiological conditions and efficient drug-targeting ability.

Microstructured PVDF Film with Improved Performance as Flexible Infrared Sensor.

Polyvinylidene fluoride (PVDF) is a very promising material for fabricating flexible infrared sensors due to its ferroelectricity as well as excellent flexibility and low fabrication cost. This work focuses on improving PVDF's pyroelectric performance by creating microstructures in the film. Simulation results suggest that the pyroelectric response of PVDF film can be improved if micro groove, square-pit or sinusoidal patterns are created on the film surface, with the grooved film showing the best pyroelectric performance.

MicroRNA-455-3p functions as a tumor suppressor by targeting HDAC2 to regulate cell cycle in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most common cancers. MicroRNA has been studied more and more deeply and may become a new target for the treatment of HCC. Here, we investigated the role of miR-455-3p in HCC progression.

HIPK3 Circular RNA Promotes Metastases of HCC Through Sponging miR-338-3p to Induce ZEB2 Expression.

Background: Upregulation of circHIPK3 has been observed in several kinds of malignancies. However, the mechanisms of circHIPK3 in HCC metastases remains unclear. We investigated the role and the mechanisms of circHIPK3 in the development of HCC.

Ectopic duodenal variceal bleed successfully treated with TIPS and 2 years follow-up: A Case Report.

Duodenal varices are an uncommon presentation of portal hypertension and can result in significant gastrointestinal bleeding with a high mortality. Diagnosis can be difficult and therapeutic options limited. We present a case of upper gastrointestinal bleeding in a woman aged 54 years with primary biliary cholangitis who was ultimately diagnosed with ectopic duodenal variceal bleed, which was successfully treated with transjugular intrahepatic portosystemic shunt.

The long noncoding RNA OTUD6B-AS1 enhances cell proliferation and the invasion of hepatocellular carcinoma cells through modulating GSKIP/Wnt/β-catenin signalling via the sequestration of miR-664b-3p.

Ovarian tumour domain containing 6B antisense RNA1 (OTUD6B-AS1), a newly identified long noncoding RNA (lncRNA), has been reported as a key cancer-related lncRNA. However, the detailed relevance of OTUD6B-AS1 in hepatocellular carcinoma (HCC) remains undetermined. This study was designed to determine the functional significance and regulatory mechanism of OTUD6B-AS1 in HCC.

MicroRNA-139-5p inhibits cell viability, migration and invasion and suppresses tumor growth by targeting HDGF in non-small cell lung cancer.

MicroRNA (miRNAs) serve key roles in the progress of various types of cancer. The expression of miRNA (miR)-139-5p is downregulated in several types of tumor and has been recognized as a tumor suppressor. However, the role of miR-139-5p in non-small cell lung cancer (NSCLC) has not been investigated in detail.

Efficacy of transcatheter arterial chemoembolization combined with sorafenib in inhibiting tumor angiogenesis in a rabbit VX2 liver cancer model.

Background: The aim of this study was to investigate the effects of transcatheter arterial chemoembolization (TACE) combined with sorafenib on tumor angiogenesis.

Materials And Methods: Thirty New Zealand rabbit VX2 liver cancer model animals were divided into five groups, which received either normal saline (A), TACE (B), sorafenib (C), sorafenib followed by TACE (D), or TACE followed by sorafenib (E). Serum vascular endothelial growth factor (VEGF) levels were measured before and after TACE via ELISA.

Two-Sided Topological Architecture on a Monolithic Flexible Substrate for Ultrasensitive Strain Sensors.

Flexible ultrasensitive strain sensors are highly desirable in view of their widespread applications in wearable electronics, health monitoring systems, and smart robots, where subtle strain detection is required. However, traditional fabrication of such sensors was done to prepare sensitive layers on bare or single-sided structural substrates, leading to limited sensitivity. Herein, a stretchable resistive-type strain sensor was demonstrated by self-assembling conductive networks onto a monolithic polydimethylsiloxane substrate with a two-sided topological design, for example, a sinusoid/auxetic binary architecture.

Polarimetric Three-Dimensional Topological Insulators/Organics Thin Film Heterojunction Photodetectors.

As a state of quantum matter with insulating bulk and gapless surface states, topological insulators (TIs) have huge potential in optoelectronic devices. On the other hand, polarization resolution photoelectric devices based on anisotropic materials have overwhelming advantages in practical applications. In this work, the 3D TIs BiTe/organics thin film heterojunction polarimetric photodetectors with high anisotropic mobility ratio, fast response time, high responsivity, and EQE in broadband spectra are presented.

ATDC promotes the growth and invasion of hepatocellular carcinoma cells by modulating GSK-3β/Wnt/β-catenin signalling.

Accumulating evidence has suggested that the ataxia telangiectasia group D complementing (ATDC) gene is an emerging cancer-related gene in multiple human cancer types. However, little is known about the role of ATDC in hepatocellular carcinoma (HCC). In this study, we aimed to investigate the expression level, biological function and underlying mechanism of ATDC in HCC.

High-Performance Paper-Based Capacitive Flexible Pressure Sensor and Its Application in Human-Related Measurement.

Flexible pressure sensors (FPS) have shown wide applications in artificial robotics, wearable devices, electronic skins, and biomedical systems; however, complicated procedures like micromachining and micromolding are often involved to achieve high performance of the sensor. In this work, a novel capacitive FPS was prepared by using silver nanowire (AgNW)-paper substrates as electrodes and polydimethylsiloxane (PDMS) as dielectrics, and results revealed that the sensitivity and dynamic range of the as-prepared sensor were 1.05 kPa and 1 Pa to 2 kPa, respectively, which were comparable to the state-of-the-art ones; practical application measurements further indicated that the capacitive FPS was capable of detecting bending, finger tap, and human speech as well as identifying object profile; therefore, it shows good potential for applying in artificial skin and wearable devices.