Pianno: a probabilistic framework automating semantic annotation for spatial transcriptomics.

Spatial transcriptomics has revolutionized the study of gene expression within tissues, while preserving spatial context. However, annotating spatial spots' biological identity remains a challenge. To tackle this, we introduce Pianno, a Bayesian framework automating structural semantics annotation based on marker genes.

Observational study of aerosol-induced impact on planetary boundary layer based on lidar and sunphotometer in Beijing.

Atmospheric aerosols have been found to influence the development of planetary boundary layer (PBL) and hence to aggravate haze pollution in megacities. PBL height (PBLH) determines the vertical extent to which the most pollutant effectively disperses and is a key argument in pollution study. In this study, we quantitatively evaluate aerosol radiation effect on PBL, as well as assessment of surface cooling effect and atmosphere heating effect.

Potassium 2-(l-hydroxypentyl)-benzoate attenuates neuroinflammatory responses and upregulates heme oxygenase-1 in systemic lipopolysaccharide-induced inflammation in mice.

A neuroinflammatory response is commonly involved in the progression of many neurodegenerative diseases. Potassium 2-(1-hydroxypentyl)-benzoate (PHPB), a novel neuroprotective compound, has shown promising effects in the treatment of ischemic stroke and Alzheimer׳s disease (AD). In the present study, the anti-inflammatory effects of PHPB were investigated in the plasma and brain of C57BL/6 mice administered a single intraperitoneal (i.

Bioactive Benzofuran Derivatives from Cortex Mori Radicis, and Their Neuroprotective and Analgesic Activities Mediated by mGluR₁.

Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis. The new compounds were identified as (9)-moracin P 3'--α-l-arabinopyranoside (), (9)-moracin P 9--β-d-glucopyranoside (), (9)-moracin P 3'--β-d-glucopyranoside (), and (9)-moracin O 10--β-d-glucopyranoside () based on the spectroscopic interpretation and chemical analysis. Three benzofuran-type stilbenes, moracin O (), R (), and P () showed significant neuroprotective activity against glutamate-induced cell death in SK-N-SH cells.

[Progress of clinical trials in Alzheimer’s disease drugs].

Alzheimer’s disease(AD) is a chronic progressive neurodegenerative disease. The pathogenesis of AD is unclear, and it is presently incurable. Medicines currently available for AD treatment are only for improving the cognitive symptoms, but not able to stop or delay disease progression.

Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum.

Twenty polycyclic polyprenylated acylphloroglucinols (PPAPs), including the new compounds hyperscabrones A-I (1-9), were isolated from the air-dried aerial parts of Hypericum scabrum. These compounds comprise seven different structural types. All structures were determined by NMR spectroscopic methods and both experimental and calculated electronic circular dichroism (ECD) spectra.